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Investigating the Central Nervous System Disposition of Actinomycin D: Implementation and Evaluation of Cerebral Microdialysis and Brain Tissue Measurements Supported by UPLC-MS/MS Quantification

Actinomycin D is a potent cytotoxic drug against pediatric (and other) tumors that is thought to barely cross the blood–brain barrier. To evaluate its potential applicability for the treatment of patients with central nervous system (CNS) tumors, we established a cerebral microdialysis model in free...

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Detalles Bibliográficos
Autores principales:	Benzel, Julia, Bajraktari-Sylejmani, Gzona, Uhl, Philipp, Davis, Abigail, Nair, Sreenath, Pfister, Stefan M., Haefeli, Walter E., Weiss, Johanna, Burhenne, Jürgen, Pajtler, Kristian W., Sauter, Max
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466300/ https://www.ncbi.nlm.nih.gov/pubmed/34575574 http://dx.doi.org/10.3390/pharmaceutics13091498

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