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Cutaneous Metastasis from Colorectal Cancer: Making Light on an Unusual and Misdiagnosed Event

Cutaneous metastasis from solid tumors is a rare event and usually represents a late occurrence in the natural history of an advanced visceral malignancy. Rarely, cutaneous metastasis has been described in colorectal cancer patients. The most frequent cutaneous site of colorectal metastasis is the s...

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Autores principales: Parente, Paola, Ciardiello, Davide, Reggiani Bonetti, Luca, Famiglietti, Vincenzo, Cazzato, Gerardo, Caramaschi, Stefania, Attino, Vito, Urbano, Diego, Di Maggio, Giuseppe, Ingravallo, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466304/
https://www.ncbi.nlm.nih.gov/pubmed/34575102
http://dx.doi.org/10.3390/life11090954
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author Parente, Paola
Ciardiello, Davide
Reggiani Bonetti, Luca
Famiglietti, Vincenzo
Cazzato, Gerardo
Caramaschi, Stefania
Attino, Vito
Urbano, Diego
Di Maggio, Giuseppe
Ingravallo, Giuseppe
author_facet Parente, Paola
Ciardiello, Davide
Reggiani Bonetti, Luca
Famiglietti, Vincenzo
Cazzato, Gerardo
Caramaschi, Stefania
Attino, Vito
Urbano, Diego
Di Maggio, Giuseppe
Ingravallo, Giuseppe
author_sort Parente, Paola
collection PubMed
description Cutaneous metastasis from solid tumors is a rare event and usually represents a late occurrence in the natural history of an advanced visceral malignancy. Rarely, cutaneous metastasis has been described in colorectal cancer patients. The most frequent cutaneous site of colorectal metastasis is the surgical scar in the abdomen following the removal of the primary malignancy, followed by the extremities, perineum, head, neck, and penis. Metastases to the thigh and back of the trunk are anecdotical. Dermatological diagnosis of cutaneous metastasis can be quite complex, especially in unusual sites, such as in the facial skin or thorax and in cases of single cutaneous lesions since metastasis from colorectal cancer is not usually the first clinical hypothesis, leading to misdiagnosis. To date, due to the rarity of cutaneous metastasis from colorectal cancer, little evidence, most of which is based on case reports and very small case series, is currently available. Therefore, a better understanding of the clinic-pathological characteristics of this unusual metastatic site represents an unmet clinical need. We present a large series of 29 cutaneous metastases from colorectal cancer with particular concerns regarding anatomic localization and the time of onset with respect to primitive colorectal cancer and visceral metastases.
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spelling pubmed-84663042021-09-27 Cutaneous Metastasis from Colorectal Cancer: Making Light on an Unusual and Misdiagnosed Event Parente, Paola Ciardiello, Davide Reggiani Bonetti, Luca Famiglietti, Vincenzo Cazzato, Gerardo Caramaschi, Stefania Attino, Vito Urbano, Diego Di Maggio, Giuseppe Ingravallo, Giuseppe Life (Basel) Article Cutaneous metastasis from solid tumors is a rare event and usually represents a late occurrence in the natural history of an advanced visceral malignancy. Rarely, cutaneous metastasis has been described in colorectal cancer patients. The most frequent cutaneous site of colorectal metastasis is the surgical scar in the abdomen following the removal of the primary malignancy, followed by the extremities, perineum, head, neck, and penis. Metastases to the thigh and back of the trunk are anecdotical. Dermatological diagnosis of cutaneous metastasis can be quite complex, especially in unusual sites, such as in the facial skin or thorax and in cases of single cutaneous lesions since metastasis from colorectal cancer is not usually the first clinical hypothesis, leading to misdiagnosis. To date, due to the rarity of cutaneous metastasis from colorectal cancer, little evidence, most of which is based on case reports and very small case series, is currently available. Therefore, a better understanding of the clinic-pathological characteristics of this unusual metastatic site represents an unmet clinical need. We present a large series of 29 cutaneous metastases from colorectal cancer with particular concerns regarding anatomic localization and the time of onset with respect to primitive colorectal cancer and visceral metastases. MDPI 2021-09-11 /pmc/articles/PMC8466304/ /pubmed/34575102 http://dx.doi.org/10.3390/life11090954 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Parente, Paola
Ciardiello, Davide
Reggiani Bonetti, Luca
Famiglietti, Vincenzo
Cazzato, Gerardo
Caramaschi, Stefania
Attino, Vito
Urbano, Diego
Di Maggio, Giuseppe
Ingravallo, Giuseppe
Cutaneous Metastasis from Colorectal Cancer: Making Light on an Unusual and Misdiagnosed Event
title Cutaneous Metastasis from Colorectal Cancer: Making Light on an Unusual and Misdiagnosed Event
title_full Cutaneous Metastasis from Colorectal Cancer: Making Light on an Unusual and Misdiagnosed Event
title_fullStr Cutaneous Metastasis from Colorectal Cancer: Making Light on an Unusual and Misdiagnosed Event
title_full_unstemmed Cutaneous Metastasis from Colorectal Cancer: Making Light on an Unusual and Misdiagnosed Event
title_short Cutaneous Metastasis from Colorectal Cancer: Making Light on an Unusual and Misdiagnosed Event
title_sort cutaneous metastasis from colorectal cancer: making light on an unusual and misdiagnosed event
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466304/
https://www.ncbi.nlm.nih.gov/pubmed/34575102
http://dx.doi.org/10.3390/life11090954
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