Conservation in the Iron Responsive Element Family

Iron responsive elements (IREs) are mRNA stem-loop targets for translational control by the two iron regulatory proteins IRP1 and IRP2. They are found in the untranslated regions (UTRs) of genes that code for proteins involved in iron metabolism. There are ten “classic” IRE types that define the con...

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Detalles Bibliográficos
Autor principal: Volz, Karl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466369/
https://www.ncbi.nlm.nih.gov/pubmed/34573347
http://dx.doi.org/10.3390/genes12091365
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author Volz, Karl
author_facet Volz, Karl
author_sort Volz, Karl
collection PubMed
description Iron responsive elements (IREs) are mRNA stem-loop targets for translational control by the two iron regulatory proteins IRP1 and IRP2. They are found in the untranslated regions (UTRs) of genes that code for proteins involved in iron metabolism. There are ten “classic” IRE types that define the conserved secondary and tertiary structure elements necessary for proper IRP binding, and there are 83 published “IRE-like” sequences, most of which depart from the established IRE model. Here are structurally-guided discussions regarding the essential features of an IRE and what is important for IRE family membership.
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spelling pubmed-84663692021-09-27 Conservation in the Iron Responsive Element Family Volz, Karl Genes (Basel) Review Iron responsive elements (IREs) are mRNA stem-loop targets for translational control by the two iron regulatory proteins IRP1 and IRP2. They are found in the untranslated regions (UTRs) of genes that code for proteins involved in iron metabolism. There are ten “classic” IRE types that define the conserved secondary and tertiary structure elements necessary for proper IRP binding, and there are 83 published “IRE-like” sequences, most of which depart from the established IRE model. Here are structurally-guided discussions regarding the essential features of an IRE and what is important for IRE family membership. MDPI 2021-08-30 /pmc/articles/PMC8466369/ /pubmed/34573347 http://dx.doi.org/10.3390/genes12091365 Text en © 2021 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Volz, Karl
Conservation in the Iron Responsive Element Family
title Conservation in the Iron Responsive Element Family
title_full Conservation in the Iron Responsive Element Family
title_fullStr Conservation in the Iron Responsive Element Family
title_full_unstemmed Conservation in the Iron Responsive Element Family
title_short Conservation in the Iron Responsive Element Family
title_sort conservation in the iron responsive element family
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466369/
https://www.ncbi.nlm.nih.gov/pubmed/34573347
http://dx.doi.org/10.3390/genes12091365
work_keys_str_mv AT volzkarl conservationintheironresponsiveelementfamily

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