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Optical Monitoring of the Biodegradation of Porous and Solid Silicon Nanoparticles

Silicon nanoparticles (SiNP) are currently of great interest, especially in biomedicine, because of their unique physicochemical properties combined with biodegradability. SiNPs can be obtained in various ways and can have either a non-porous solid (sol-) or porous (por-) structure. In this work, we...

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Autores principales: Gongalsky, Maxim B., Pervushin, Nikolay V., Maksutova, Daria E., Tsurikova, Uliana A., Putintsev, Pavel P., Gyuppenen, Oleg D., Evstratova, Yana V., Shalygina, Olga A., Kopeina, Gelina S., Kudryavtsev, Andrey A., Zhivotovsky, Boris, Osminkina, Liubov A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466475/
https://www.ncbi.nlm.nih.gov/pubmed/34578485
http://dx.doi.org/10.3390/nano11092167
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author Gongalsky, Maxim B.
Pervushin, Nikolay V.
Maksutova, Daria E.
Tsurikova, Uliana A.
Putintsev, Pavel P.
Gyuppenen, Oleg D.
Evstratova, Yana V.
Shalygina, Olga A.
Kopeina, Gelina S.
Kudryavtsev, Andrey A.
Zhivotovsky, Boris
Osminkina, Liubov A.
author_facet Gongalsky, Maxim B.
Pervushin, Nikolay V.
Maksutova, Daria E.
Tsurikova, Uliana A.
Putintsev, Pavel P.
Gyuppenen, Oleg D.
Evstratova, Yana V.
Shalygina, Olga A.
Kopeina, Gelina S.
Kudryavtsev, Andrey A.
Zhivotovsky, Boris
Osminkina, Liubov A.
author_sort Gongalsky, Maxim B.
collection PubMed
description Silicon nanoparticles (SiNP) are currently of great interest, especially in biomedicine, because of their unique physicochemical properties combined with biodegradability. SiNPs can be obtained in various ways and can have either a non-porous solid (sol-) or porous (por-) structure. In this work, we carry out detailed optical monitoring of sol- and por-SiNP biodegradation using Raman and photoluminescence (PL) micro-spectroscopy. SiNPs were obtained by ultrasound grinding of sol- or por-silicon nanowires, created by silver-assisted chemical etching of crystalline Si with different doping levels. In this case, sol-SiNPs consist of nanocrystals 30 nm in size, while por-SiNPs consist of small 3 nm nanocrystals and 16 nm pores. Both SiNPs show low in vitro cytotoxicity towards MCF-7 and HEK293T cells up to 800 μg/mL. The appearance of the F-band (blue–yellow) PL, as well as a decrease in the intensity of the Raman signal, indicate the gradual dissolution of the sol-SiNPs during 20 days of incubation. At the same time, the rapid dissolution of por-SiNP within 24 h is identified by the quenching of their S-band (red) PL and the disappearance of the Raman signal. The obtained results are important for development of intelligent biodegradable drug delivery systems based on SiNPs.
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spelling pubmed-84664752021-09-27 Optical Monitoring of the Biodegradation of Porous and Solid Silicon Nanoparticles Gongalsky, Maxim B. Pervushin, Nikolay V. Maksutova, Daria E. Tsurikova, Uliana A. Putintsev, Pavel P. Gyuppenen, Oleg D. Evstratova, Yana V. Shalygina, Olga A. Kopeina, Gelina S. Kudryavtsev, Andrey A. Zhivotovsky, Boris Osminkina, Liubov A. Nanomaterials (Basel) Article Silicon nanoparticles (SiNP) are currently of great interest, especially in biomedicine, because of their unique physicochemical properties combined with biodegradability. SiNPs can be obtained in various ways and can have either a non-porous solid (sol-) or porous (por-) structure. In this work, we carry out detailed optical monitoring of sol- and por-SiNP biodegradation using Raman and photoluminescence (PL) micro-spectroscopy. SiNPs were obtained by ultrasound grinding of sol- or por-silicon nanowires, created by silver-assisted chemical etching of crystalline Si with different doping levels. In this case, sol-SiNPs consist of nanocrystals 30 nm in size, while por-SiNPs consist of small 3 nm nanocrystals and 16 nm pores. Both SiNPs show low in vitro cytotoxicity towards MCF-7 and HEK293T cells up to 800 μg/mL. The appearance of the F-band (blue–yellow) PL, as well as a decrease in the intensity of the Raman signal, indicate the gradual dissolution of the sol-SiNPs during 20 days of incubation. At the same time, the rapid dissolution of por-SiNP within 24 h is identified by the quenching of their S-band (red) PL and the disappearance of the Raman signal. The obtained results are important for development of intelligent biodegradable drug delivery systems based on SiNPs. MDPI 2021-08-25 /pmc/articles/PMC8466475/ /pubmed/34578485 http://dx.doi.org/10.3390/nano11092167 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gongalsky, Maxim B.
Pervushin, Nikolay V.
Maksutova, Daria E.
Tsurikova, Uliana A.
Putintsev, Pavel P.
Gyuppenen, Oleg D.
Evstratova, Yana V.
Shalygina, Olga A.
Kopeina, Gelina S.
Kudryavtsev, Andrey A.
Zhivotovsky, Boris
Osminkina, Liubov A.
Optical Monitoring of the Biodegradation of Porous and Solid Silicon Nanoparticles
title Optical Monitoring of the Biodegradation of Porous and Solid Silicon Nanoparticles
title_full Optical Monitoring of the Biodegradation of Porous and Solid Silicon Nanoparticles
title_fullStr Optical Monitoring of the Biodegradation of Porous and Solid Silicon Nanoparticles
title_full_unstemmed Optical Monitoring of the Biodegradation of Porous and Solid Silicon Nanoparticles
title_short Optical Monitoring of the Biodegradation of Porous and Solid Silicon Nanoparticles
title_sort optical monitoring of the biodegradation of porous and solid silicon nanoparticles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466475/
https://www.ncbi.nlm.nih.gov/pubmed/34578485
http://dx.doi.org/10.3390/nano11092167
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