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The Labile Iron Pool Reacts Rapidly and Catalytically with Peroxynitrite

While investigating peroxynitrite-dependent oxidation in murine RAW 264.7 macrophage cells, we observed that removal of the Labile Iron Pool (LIP) by chelation increases the intracellular oxidation of the fluorescent indicator H(2)DCF, so we concluded that the LIP reacts with peroxynitrite and decre...

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Detalles Bibliográficos
Autores principales: Condeles, André Luís, Toledo Junior, José Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466499/
https://www.ncbi.nlm.nih.gov/pubmed/34572543
http://dx.doi.org/10.3390/biom11091331