Cargando…

Coronary Calcium Scoring with First Generation Dual-Source Photon-Counting CT—First Evidence from Phantom and In-Vivo Scans

We evaluated the accuracy of coronary artery calcium (CAC) scoring on a dual-source photon-counting detector CT (PCD-CT). An anthropomorphic chest phantom underwent ECG-gated sequential scanning on a PCD-CT at 120 kV with four radiation dose levels (CTDIvol, 2.0–8.6 mGy). Polychromatic images at 120...

Descripción completa

Detalles Bibliográficos
Autores principales: Eberhard, Matthias, Mergen, Victor, Higashigaito, Kai, Allmendinger, Thomas, Manka, Robert, Flohr, Thomas, Schmidt, Bernhard, Euler, Andre, Alkadhi, Hatem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466604/
https://www.ncbi.nlm.nih.gov/pubmed/34574049
http://dx.doi.org/10.3390/diagnostics11091708
_version_ 1784573183886622720
author Eberhard, Matthias
Mergen, Victor
Higashigaito, Kai
Allmendinger, Thomas
Manka, Robert
Flohr, Thomas
Schmidt, Bernhard
Euler, Andre
Alkadhi, Hatem
author_facet Eberhard, Matthias
Mergen, Victor
Higashigaito, Kai
Allmendinger, Thomas
Manka, Robert
Flohr, Thomas
Schmidt, Bernhard
Euler, Andre
Alkadhi, Hatem
author_sort Eberhard, Matthias
collection PubMed
description We evaluated the accuracy of coronary artery calcium (CAC) scoring on a dual-source photon-counting detector CT (PCD-CT). An anthropomorphic chest phantom underwent ECG-gated sequential scanning on a PCD-CT at 120 kV with four radiation dose levels (CTDIvol, 2.0–8.6 mGy). Polychromatic images at 120 kV (T3D) and virtual monoenergetic images (VMI), from 60 to 75 keV without quantum iterative reconstruction (no QIR) and QIR strength levels 1–4, were reconstructed. For reference, the same phantom was scanned on a conventional energy-integrating detector CT (120 kV; filtered back projection) at identical radiation doses. CAC scoring in 20 patients with PCD-CT (120 kV; no QIR and QIR 1–4) were included. In the phantom, there were no differences between CAC scores of different radiation doses (all, p > 0.05). Images with 70 keV, no QIR (CAC score, 649); 65 keV, QIR 3 (656); 65 keV; QIR4 (648) and T3D, QIR4 (656) showed a <1% deviation to the reference (653). CAC scores significantly decreased at increasing QIR levels (all, p < 0.001) and for each 5 keV-increase (all, p < 0.001). Patient data (median CAC score: 86 [inter-quartile range: 38–978] at 70 keV) confirmed relationships and differences between reconstructions from the phantom. First phantom and in-vivo experience with a clinical dual-source PCD-CT system shows accurate CAC scoring with VMI reconstructions at different radiation dose levels.
format Online
Article
Text
id pubmed-8466604
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-84666042021-09-27 Coronary Calcium Scoring with First Generation Dual-Source Photon-Counting CT—First Evidence from Phantom and In-Vivo Scans Eberhard, Matthias Mergen, Victor Higashigaito, Kai Allmendinger, Thomas Manka, Robert Flohr, Thomas Schmidt, Bernhard Euler, Andre Alkadhi, Hatem Diagnostics (Basel) Article We evaluated the accuracy of coronary artery calcium (CAC) scoring on a dual-source photon-counting detector CT (PCD-CT). An anthropomorphic chest phantom underwent ECG-gated sequential scanning on a PCD-CT at 120 kV with four radiation dose levels (CTDIvol, 2.0–8.6 mGy). Polychromatic images at 120 kV (T3D) and virtual monoenergetic images (VMI), from 60 to 75 keV without quantum iterative reconstruction (no QIR) and QIR strength levels 1–4, were reconstructed. For reference, the same phantom was scanned on a conventional energy-integrating detector CT (120 kV; filtered back projection) at identical radiation doses. CAC scoring in 20 patients with PCD-CT (120 kV; no QIR and QIR 1–4) were included. In the phantom, there were no differences between CAC scores of different radiation doses (all, p > 0.05). Images with 70 keV, no QIR (CAC score, 649); 65 keV, QIR 3 (656); 65 keV; QIR4 (648) and T3D, QIR4 (656) showed a <1% deviation to the reference (653). CAC scores significantly decreased at increasing QIR levels (all, p < 0.001) and for each 5 keV-increase (all, p < 0.001). Patient data (median CAC score: 86 [inter-quartile range: 38–978] at 70 keV) confirmed relationships and differences between reconstructions from the phantom. First phantom and in-vivo experience with a clinical dual-source PCD-CT system shows accurate CAC scoring with VMI reconstructions at different radiation dose levels. MDPI 2021-09-18 /pmc/articles/PMC8466604/ /pubmed/34574049 http://dx.doi.org/10.3390/diagnostics11091708 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Eberhard, Matthias
Mergen, Victor
Higashigaito, Kai
Allmendinger, Thomas
Manka, Robert
Flohr, Thomas
Schmidt, Bernhard
Euler, Andre
Alkadhi, Hatem
Coronary Calcium Scoring with First Generation Dual-Source Photon-Counting CT—First Evidence from Phantom and In-Vivo Scans
title Coronary Calcium Scoring with First Generation Dual-Source Photon-Counting CT—First Evidence from Phantom and In-Vivo Scans
title_full Coronary Calcium Scoring with First Generation Dual-Source Photon-Counting CT—First Evidence from Phantom and In-Vivo Scans
title_fullStr Coronary Calcium Scoring with First Generation Dual-Source Photon-Counting CT—First Evidence from Phantom and In-Vivo Scans
title_full_unstemmed Coronary Calcium Scoring with First Generation Dual-Source Photon-Counting CT—First Evidence from Phantom and In-Vivo Scans
title_short Coronary Calcium Scoring with First Generation Dual-Source Photon-Counting CT—First Evidence from Phantom and In-Vivo Scans
title_sort coronary calcium scoring with first generation dual-source photon-counting ct—first evidence from phantom and in-vivo scans
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466604/
https://www.ncbi.nlm.nih.gov/pubmed/34574049
http://dx.doi.org/10.3390/diagnostics11091708
work_keys_str_mv AT eberhardmatthias coronarycalciumscoringwithfirstgenerationdualsourcephotoncountingctfirstevidencefromphantomandinvivoscans
AT mergenvictor coronarycalciumscoringwithfirstgenerationdualsourcephotoncountingctfirstevidencefromphantomandinvivoscans
AT higashigaitokai coronarycalciumscoringwithfirstgenerationdualsourcephotoncountingctfirstevidencefromphantomandinvivoscans
AT allmendingerthomas coronarycalciumscoringwithfirstgenerationdualsourcephotoncountingctfirstevidencefromphantomandinvivoscans
AT mankarobert coronarycalciumscoringwithfirstgenerationdualsourcephotoncountingctfirstevidencefromphantomandinvivoscans
AT flohrthomas coronarycalciumscoringwithfirstgenerationdualsourcephotoncountingctfirstevidencefromphantomandinvivoscans
AT schmidtbernhard coronarycalciumscoringwithfirstgenerationdualsourcephotoncountingctfirstevidencefromphantomandinvivoscans
AT eulerandre coronarycalciumscoringwithfirstgenerationdualsourcephotoncountingctfirstevidencefromphantomandinvivoscans
AT alkadhihatem coronarycalciumscoringwithfirstgenerationdualsourcephotoncountingctfirstevidencefromphantomandinvivoscans