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Balance of Drug Residence and Diffusion in Lacrimal Fluid Determine Ocular Bioavailability in In Situ Gels Incorporating Tranilast Nanoparticles

We previously designed ophthalmic formulations (nTRA) containing tranilast nanoparticles (Tra-NPs) with high uptake into ocular tissues. In this study, we used in situ gel (ISG) bases comprising combinations of pluronic F127 (F127) and methylcellulose (MC/F127), pluronic F68 (F68/F127), and Carbopol...

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Detalles Bibliográficos
Autores principales:	Minami, Misa, Otake, Hiroko, Nakazawa, Yosuke, Okamoto, Norio, Yamamoto, Naoki, Sasaki, Hiroshi, Nagai, Noriaki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466670/ https://www.ncbi.nlm.nih.gov/pubmed/34575501 http://dx.doi.org/10.3390/pharmaceutics13091425

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