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Gut Leakage Markers in Response to Strenuous Exercise in Patients with Suspected Coronary Artery Disease

Elevated levels of gut leakage markers have been shown after strenuous exercise in healthy individuals. Any association between a temporary increase in these markers and the presence of coronary artery disease (CAD) is unknown. We therefore aimed to explore circulating gut leakage markers in respons...

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Autores principales: Aune, Susanne Kristine, Cwikiel, Joanna, Flaa, Arnljot, Arnesen, Harald, Solheim, Svein, Awoyemi, Ayodeji, Trøseid, Marius, Seljeflot, Ingebjørg, Helseth, Ragnhild
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466709/
https://www.ncbi.nlm.nih.gov/pubmed/34571843
http://dx.doi.org/10.3390/cells10092193
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author Aune, Susanne Kristine
Cwikiel, Joanna
Flaa, Arnljot
Arnesen, Harald
Solheim, Svein
Awoyemi, Ayodeji
Trøseid, Marius
Seljeflot, Ingebjørg
Helseth, Ragnhild
author_facet Aune, Susanne Kristine
Cwikiel, Joanna
Flaa, Arnljot
Arnesen, Harald
Solheim, Svein
Awoyemi, Ayodeji
Trøseid, Marius
Seljeflot, Ingebjørg
Helseth, Ragnhild
author_sort Aune, Susanne Kristine
collection PubMed
description Elevated levels of gut leakage markers have been shown after strenuous exercise in healthy individuals. Any association between a temporary increase in these markers and the presence of coronary artery disease (CAD) is unknown. We therefore aimed to explore circulating gut leakage markers in response to a bout of strenuous exercise in patients with symptoms of CAD. Patients referred to exercise stress testing due to symptoms of CAD were included (n = 287). A maximal exercise ECG stress test was performed and venous blood samples were drawn at rest and within five minutes after, for analysis of soluble cluster of differentiation 14 (sCD14), lipopolysaccharide-binding protein (LBP), intestinal fatty-acid binding protein (I-FABP), lipopolysaccharide (LPS) and gene expression of toll-like receptor 4 (TLR4) in circulating leukocytes. Patients then underwent coronary angiography. LPS, LBP and sCD14 increased significantly after strenuous exercise in patients with symptoms of CAD, suggesting that even short bouts of vigorous exercise are associated with gut leakage. The gene expression of TLR4 decreased significantly after exercise, possibly as a negative feedback to the increase in LPS. There were no differences in exercise-induced changes between the groups of CAD, suggesting gut leakage to be independent of the presence of CAD.
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spelling pubmed-84667092021-09-27 Gut Leakage Markers in Response to Strenuous Exercise in Patients with Suspected Coronary Artery Disease Aune, Susanne Kristine Cwikiel, Joanna Flaa, Arnljot Arnesen, Harald Solheim, Svein Awoyemi, Ayodeji Trøseid, Marius Seljeflot, Ingebjørg Helseth, Ragnhild Cells Article Elevated levels of gut leakage markers have been shown after strenuous exercise in healthy individuals. Any association between a temporary increase in these markers and the presence of coronary artery disease (CAD) is unknown. We therefore aimed to explore circulating gut leakage markers in response to a bout of strenuous exercise in patients with symptoms of CAD. Patients referred to exercise stress testing due to symptoms of CAD were included (n = 287). A maximal exercise ECG stress test was performed and venous blood samples were drawn at rest and within five minutes after, for analysis of soluble cluster of differentiation 14 (sCD14), lipopolysaccharide-binding protein (LBP), intestinal fatty-acid binding protein (I-FABP), lipopolysaccharide (LPS) and gene expression of toll-like receptor 4 (TLR4) in circulating leukocytes. Patients then underwent coronary angiography. LPS, LBP and sCD14 increased significantly after strenuous exercise in patients with symptoms of CAD, suggesting that even short bouts of vigorous exercise are associated with gut leakage. The gene expression of TLR4 decreased significantly after exercise, possibly as a negative feedback to the increase in LPS. There were no differences in exercise-induced changes between the groups of CAD, suggesting gut leakage to be independent of the presence of CAD. MDPI 2021-08-25 /pmc/articles/PMC8466709/ /pubmed/34571843 http://dx.doi.org/10.3390/cells10092193 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Aune, Susanne Kristine
Cwikiel, Joanna
Flaa, Arnljot
Arnesen, Harald
Solheim, Svein
Awoyemi, Ayodeji
Trøseid, Marius
Seljeflot, Ingebjørg
Helseth, Ragnhild
Gut Leakage Markers in Response to Strenuous Exercise in Patients with Suspected Coronary Artery Disease
title Gut Leakage Markers in Response to Strenuous Exercise in Patients with Suspected Coronary Artery Disease
title_full Gut Leakage Markers in Response to Strenuous Exercise in Patients with Suspected Coronary Artery Disease
title_fullStr Gut Leakage Markers in Response to Strenuous Exercise in Patients with Suspected Coronary Artery Disease
title_full_unstemmed Gut Leakage Markers in Response to Strenuous Exercise in Patients with Suspected Coronary Artery Disease
title_short Gut Leakage Markers in Response to Strenuous Exercise in Patients with Suspected Coronary Artery Disease
title_sort gut leakage markers in response to strenuous exercise in patients with suspected coronary artery disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466709/
https://www.ncbi.nlm.nih.gov/pubmed/34571843
http://dx.doi.org/10.3390/cells10092193
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