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Gut Microbiota-Modulated Metabolomic Profiling Shapes the Etiology and Pathogenesis of Autoimmune Diseases

Autoimmunity is a complex and multifaceted process that contributes to widespread functional decline that affects multiple organs and tissues. The pandemic of autoimmune diseases, which are a global health concern, augments in both the prevalence and incidence of autoimmune diseases, including type...

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Autores principales: Tsai, Yi-Wen, Dong, Jia-Ling, Jian, Yun-Jie, Fu, Shin-Huei, Chien, Ming-Wei, Liu, Yu-Wen, Hsu, Chao-Yuan, Sytwu, Huey-Kang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466726/
https://www.ncbi.nlm.nih.gov/pubmed/34576825
http://dx.doi.org/10.3390/microorganisms9091930
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author Tsai, Yi-Wen
Dong, Jia-Ling
Jian, Yun-Jie
Fu, Shin-Huei
Chien, Ming-Wei
Liu, Yu-Wen
Hsu, Chao-Yuan
Sytwu, Huey-Kang
author_facet Tsai, Yi-Wen
Dong, Jia-Ling
Jian, Yun-Jie
Fu, Shin-Huei
Chien, Ming-Wei
Liu, Yu-Wen
Hsu, Chao-Yuan
Sytwu, Huey-Kang
author_sort Tsai, Yi-Wen
collection PubMed
description Autoimmunity is a complex and multifaceted process that contributes to widespread functional decline that affects multiple organs and tissues. The pandemic of autoimmune diseases, which are a global health concern, augments in both the prevalence and incidence of autoimmune diseases, including type 1 diabetes, multiple sclerosis, and rheumatoid arthritis. The development of autoimmune diseases is phenotypically associated with gut microbiota-modulated features at the molecular and cellular levels. The etiology and pathogenesis of autoimmune diseases comprise the alterations of immune systems with the innate and adaptive immune cell infiltration into specific organs and the augmented production of proinflammatory cytokines stimulated by commensal microbiota. However, the relative importance and mechanistic interrelationships between the gut microbial community and the immune system during progression of autoimmune diseases are still not well understood. In this review, we describe studies on the profiling of gut microbial signatures for the modulation of immunological homeostasis in multiple inflammatory diseases, elucidate their critical roles in the etiology and pathogenesis of autoimmune diseases, and discuss the implications of these findings for these disorders. Targeting intestinal microbiome and its metabolomic associations with the phenotype of autoimmunity will enable the progress of developing new therapeutic strategies to counteract microorganism-related immune dysfunction in these autoimmune diseases.
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spelling pubmed-84667262021-09-27 Gut Microbiota-Modulated Metabolomic Profiling Shapes the Etiology and Pathogenesis of Autoimmune Diseases Tsai, Yi-Wen Dong, Jia-Ling Jian, Yun-Jie Fu, Shin-Huei Chien, Ming-Wei Liu, Yu-Wen Hsu, Chao-Yuan Sytwu, Huey-Kang Microorganisms Review Autoimmunity is a complex and multifaceted process that contributes to widespread functional decline that affects multiple organs and tissues. The pandemic of autoimmune diseases, which are a global health concern, augments in both the prevalence and incidence of autoimmune diseases, including type 1 diabetes, multiple sclerosis, and rheumatoid arthritis. The development of autoimmune diseases is phenotypically associated with gut microbiota-modulated features at the molecular and cellular levels. The etiology and pathogenesis of autoimmune diseases comprise the alterations of immune systems with the innate and adaptive immune cell infiltration into specific organs and the augmented production of proinflammatory cytokines stimulated by commensal microbiota. However, the relative importance and mechanistic interrelationships between the gut microbial community and the immune system during progression of autoimmune diseases are still not well understood. In this review, we describe studies on the profiling of gut microbial signatures for the modulation of immunological homeostasis in multiple inflammatory diseases, elucidate their critical roles in the etiology and pathogenesis of autoimmune diseases, and discuss the implications of these findings for these disorders. Targeting intestinal microbiome and its metabolomic associations with the phenotype of autoimmunity will enable the progress of developing new therapeutic strategies to counteract microorganism-related immune dysfunction in these autoimmune diseases. MDPI 2021-09-10 /pmc/articles/PMC8466726/ /pubmed/34576825 http://dx.doi.org/10.3390/microorganisms9091930 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tsai, Yi-Wen
Dong, Jia-Ling
Jian, Yun-Jie
Fu, Shin-Huei
Chien, Ming-Wei
Liu, Yu-Wen
Hsu, Chao-Yuan
Sytwu, Huey-Kang
Gut Microbiota-Modulated Metabolomic Profiling Shapes the Etiology and Pathogenesis of Autoimmune Diseases
title Gut Microbiota-Modulated Metabolomic Profiling Shapes the Etiology and Pathogenesis of Autoimmune Diseases
title_full Gut Microbiota-Modulated Metabolomic Profiling Shapes the Etiology and Pathogenesis of Autoimmune Diseases
title_fullStr Gut Microbiota-Modulated Metabolomic Profiling Shapes the Etiology and Pathogenesis of Autoimmune Diseases
title_full_unstemmed Gut Microbiota-Modulated Metabolomic Profiling Shapes the Etiology and Pathogenesis of Autoimmune Diseases
title_short Gut Microbiota-Modulated Metabolomic Profiling Shapes the Etiology and Pathogenesis of Autoimmune Diseases
title_sort gut microbiota-modulated metabolomic profiling shapes the etiology and pathogenesis of autoimmune diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466726/
https://www.ncbi.nlm.nih.gov/pubmed/34576825
http://dx.doi.org/10.3390/microorganisms9091930
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