Synthetic Strategies in the Preparation of Phenanthridinones

Phenanthridinones are important heterocyclic frameworks present in a variety of complex natural products, pharmaceuticals and displaying wide range of pharmacological actions. Its structural importance has evoked a great deal of interest in the domains of organic synthesis and medicinal chemistry to...

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Detalles Bibliográficos
Autores principales: Aleti, Rajeshwar Reddy, Festa, Alexey A., Voskressensky, Leonid G., Van der Eycken, Erik V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466741/
https://www.ncbi.nlm.nih.gov/pubmed/34577030
http://dx.doi.org/10.3390/molecules26185560
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author Aleti, Rajeshwar Reddy
Festa, Alexey A.
Voskressensky, Leonid G.
Van der Eycken, Erik V.
author_facet Aleti, Rajeshwar Reddy
Festa, Alexey A.
Voskressensky, Leonid G.
Van der Eycken, Erik V.
author_sort Aleti, Rajeshwar Reddy
collection PubMed
description Phenanthridinones are important heterocyclic frameworks present in a variety of complex natural products, pharmaceuticals and displaying wide range of pharmacological actions. Its structural importance has evoked a great deal of interest in the domains of organic synthesis and medicinal chemistry to develop new synthetic methodologies, as well as novel compounds of pharmaceutical interest. This review focuses on the synthesis of phenanthridinone scaffolds by employing aryl-aryl, N-aryl, and biaryl coupling reactions, decarboxylative amidations, and photocatalyzed reactions.
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spelling pubmed-84667412021-09-27 Synthetic Strategies in the Preparation of Phenanthridinones Aleti, Rajeshwar Reddy Festa, Alexey A. Voskressensky, Leonid G. Van der Eycken, Erik V. Molecules Review Phenanthridinones are important heterocyclic frameworks present in a variety of complex natural products, pharmaceuticals and displaying wide range of pharmacological actions. Its structural importance has evoked a great deal of interest in the domains of organic synthesis and medicinal chemistry to develop new synthetic methodologies, as well as novel compounds of pharmaceutical interest. This review focuses on the synthesis of phenanthridinone scaffolds by employing aryl-aryl, N-aryl, and biaryl coupling reactions, decarboxylative amidations, and photocatalyzed reactions. MDPI 2021-09-13 /pmc/articles/PMC8466741/ /pubmed/34577030 http://dx.doi.org/10.3390/molecules26185560 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Aleti, Rajeshwar Reddy
Festa, Alexey A.
Voskressensky, Leonid G.
Van der Eycken, Erik V.
Synthetic Strategies in the Preparation of Phenanthridinones
title Synthetic Strategies in the Preparation of Phenanthridinones
title_full Synthetic Strategies in the Preparation of Phenanthridinones
title_fullStr Synthetic Strategies in the Preparation of Phenanthridinones
title_full_unstemmed Synthetic Strategies in the Preparation of Phenanthridinones
title_short Synthetic Strategies in the Preparation of Phenanthridinones
title_sort synthetic strategies in the preparation of phenanthridinones
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466741/
https://www.ncbi.nlm.nih.gov/pubmed/34577030
http://dx.doi.org/10.3390/molecules26185560
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