NAC and Vitamin D Improve CNS and Plasma Oxidative Stress in Neonatal HIE and Are Associated with Favorable Long-Term Outcomes

N-acetylcysteine (NAC) and vitamin D provide effective neuroprotection in animal models of severe or inflammation-sensitized hypoxic ischemic encephalopathy (HIE). To translate these FDA-approved drugs to HIE neonates, we conducted an early phase, open-label trial of 10 days of NAC (25, 40 mg/kg q12...

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Detalles Bibliográficos
Autores principales: Jenkins, Dorothea D, Moss, Hunter G, Brown, Truman R, Yazdani, Milad, Thayyil, Sudhin, Montaldo, Paolo, Vento, Maximo, Kuligowski, Julia, Wagner, Carol, Hollis, Bruce W, Wiest, Donald B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466838/
https://www.ncbi.nlm.nih.gov/pubmed/34572976
http://dx.doi.org/10.3390/antiox10091344

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