Cargando…

EUS-Guided Biopsy with a Novel Puncture Biopsy Forceps Needle—Feasibility Study

Endoscopic ultrasound (EUS) with fine needle aspiration (FNA) or biopsy (FNB) to diagnose lesions in the gastrointestinal tract is common. Demand for histology sampling to identify treatment-specific targets is increasing. Various core biopsy FNB needles to obtain tissue for histology are currently...

Descripción completa

Detalles Bibliográficos
Autores principales: Litjens, Geke, Gerges, Christian, Shastri, Yogesh M., Somani, Piyush, Beyna, Torsten, Neuhaus, Horst, van Laarhoven, Cornelis J. H. M., Prokop, Mathias, Siersema, Peter D., Hermans, John J., van Geenen, Erwin J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466864/
https://www.ncbi.nlm.nih.gov/pubmed/34573978
http://dx.doi.org/10.3390/diagnostics11091638
_version_ 1784573249065058304
author Litjens, Geke
Gerges, Christian
Shastri, Yogesh M.
Somani, Piyush
Beyna, Torsten
Neuhaus, Horst
van Laarhoven, Cornelis J. H. M.
Prokop, Mathias
Siersema, Peter D.
Hermans, John J.
van Geenen, Erwin J. M.
author_facet Litjens, Geke
Gerges, Christian
Shastri, Yogesh M.
Somani, Piyush
Beyna, Torsten
Neuhaus, Horst
van Laarhoven, Cornelis J. H. M.
Prokop, Mathias
Siersema, Peter D.
Hermans, John J.
van Geenen, Erwin J. M.
author_sort Litjens, Geke
collection PubMed
description Endoscopic ultrasound (EUS) with fine needle aspiration (FNA) or biopsy (FNB) to diagnose lesions in the gastrointestinal tract is common. Demand for histology sampling to identify treatment-specific targets is increasing. Various core biopsy FNB needles to obtain tissue for histology are currently available, however, with variable (37–97%) histology yields. In this multicenter study, we evaluated performance, safety, and user experience of a novel device (the puncture biopsy forceps (PBF) needle). Twenty-four procedures with the PBF needle were performed in 24 patients with a suspected pancreatic lesion (n = 10), subepithelial lesion (n = 10), lymph node (n = 3), or pararectal mass (n = 1). In 20/24 (83%) procedures, the PBF needle yielded sufficient material for interpretation (sample adequacy). In 17/24 (71%), a correct diagnosis was made with the material from the PBF needle (diagnostic accuracy). All participating endoscopists experienced a learning curve. (Per)procedural technical issues occurred in four cases (17%), but there were no adverse events. The PBF needle is a safe and potentially useful device to obtain an EUS-guided biopsy specimen. As the design of the PBF needle is different to core biopsy FNB needles, specific training will likely further improve the performance of the PBF needle. Furthermore, the design of the needle needs further improvement to make it more robust in clinical practice.
format Online
Article
Text
id pubmed-8466864
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-84668642021-09-27 EUS-Guided Biopsy with a Novel Puncture Biopsy Forceps Needle—Feasibility Study Litjens, Geke Gerges, Christian Shastri, Yogesh M. Somani, Piyush Beyna, Torsten Neuhaus, Horst van Laarhoven, Cornelis J. H. M. Prokop, Mathias Siersema, Peter D. Hermans, John J. van Geenen, Erwin J. M. Diagnostics (Basel) Article Endoscopic ultrasound (EUS) with fine needle aspiration (FNA) or biopsy (FNB) to diagnose lesions in the gastrointestinal tract is common. Demand for histology sampling to identify treatment-specific targets is increasing. Various core biopsy FNB needles to obtain tissue for histology are currently available, however, with variable (37–97%) histology yields. In this multicenter study, we evaluated performance, safety, and user experience of a novel device (the puncture biopsy forceps (PBF) needle). Twenty-four procedures with the PBF needle were performed in 24 patients with a suspected pancreatic lesion (n = 10), subepithelial lesion (n = 10), lymph node (n = 3), or pararectal mass (n = 1). In 20/24 (83%) procedures, the PBF needle yielded sufficient material for interpretation (sample adequacy). In 17/24 (71%), a correct diagnosis was made with the material from the PBF needle (diagnostic accuracy). All participating endoscopists experienced a learning curve. (Per)procedural technical issues occurred in four cases (17%), but there were no adverse events. The PBF needle is a safe and potentially useful device to obtain an EUS-guided biopsy specimen. As the design of the PBF needle is different to core biopsy FNB needles, specific training will likely further improve the performance of the PBF needle. Furthermore, the design of the needle needs further improvement to make it more robust in clinical practice. MDPI 2021-09-07 /pmc/articles/PMC8466864/ /pubmed/34573978 http://dx.doi.org/10.3390/diagnostics11091638 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Litjens, Geke
Gerges, Christian
Shastri, Yogesh M.
Somani, Piyush
Beyna, Torsten
Neuhaus, Horst
van Laarhoven, Cornelis J. H. M.
Prokop, Mathias
Siersema, Peter D.
Hermans, John J.
van Geenen, Erwin J. M.
EUS-Guided Biopsy with a Novel Puncture Biopsy Forceps Needle—Feasibility Study
title EUS-Guided Biopsy with a Novel Puncture Biopsy Forceps Needle—Feasibility Study
title_full EUS-Guided Biopsy with a Novel Puncture Biopsy Forceps Needle—Feasibility Study
title_fullStr EUS-Guided Biopsy with a Novel Puncture Biopsy Forceps Needle—Feasibility Study
title_full_unstemmed EUS-Guided Biopsy with a Novel Puncture Biopsy Forceps Needle—Feasibility Study
title_short EUS-Guided Biopsy with a Novel Puncture Biopsy Forceps Needle—Feasibility Study
title_sort eus-guided biopsy with a novel puncture biopsy forceps needle—feasibility study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466864/
https://www.ncbi.nlm.nih.gov/pubmed/34573978
http://dx.doi.org/10.3390/diagnostics11091638
work_keys_str_mv AT litjensgeke eusguidedbiopsywithanovelpuncturebiopsyforcepsneedlefeasibilitystudy
AT gergeschristian eusguidedbiopsywithanovelpuncturebiopsyforcepsneedlefeasibilitystudy
AT shastriyogeshm eusguidedbiopsywithanovelpuncturebiopsyforcepsneedlefeasibilitystudy
AT somanipiyush eusguidedbiopsywithanovelpuncturebiopsyforcepsneedlefeasibilitystudy
AT beynatorsten eusguidedbiopsywithanovelpuncturebiopsyforcepsneedlefeasibilitystudy
AT neuhaushorst eusguidedbiopsywithanovelpuncturebiopsyforcepsneedlefeasibilitystudy
AT vanlaarhovencornelisjhm eusguidedbiopsywithanovelpuncturebiopsyforcepsneedlefeasibilitystudy
AT prokopmathias eusguidedbiopsywithanovelpuncturebiopsyforcepsneedlefeasibilitystudy
AT siersemapeterd eusguidedbiopsywithanovelpuncturebiopsyforcepsneedlefeasibilitystudy
AT hermansjohnj eusguidedbiopsywithanovelpuncturebiopsyforcepsneedlefeasibilitystudy
AT vangeenenerwinjm eusguidedbiopsywithanovelpuncturebiopsyforcepsneedlefeasibilitystudy