Combined LXR and RXR Agonist Therapy Increases ABCA1 Protein Expression and Enhances ApoAI-Mediated Cholesterol Efflux in Cultured Endothelial Cells

Endothelial ABCA1 expression protects against atherosclerosis and this atheroprotective effect is partially attributed to enhancing apoAI-mediated cholesterol efflux. ABCA1 is a target gene for LXR and RXR; therefore, treating endothelial cells with LXR and/or RXR agonists may increase ABCA1 express...

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Detalles Bibliográficos
Autores principales: Huang, Kun, Jo, Hanjoong, Echesabal-Chen, Jing, Stamatikos, Alexis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466889/
https://www.ncbi.nlm.nih.gov/pubmed/34564456
http://dx.doi.org/10.3390/metabo11090640

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466889/
https://www.ncbi.nlm.nih.gov/pubmed/34564456
http://dx.doi.org/10.3390/metabo11090640

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