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High-Fat and Resveratrol Supplemented Diets Modulate Adenosine Receptors in the Cerebral Cortex of C57BL/6J and SAMP8 Mice

Neurodegenerative disorders are devastating diseases in which aging is a major risk factor. High-fat diet (HFD) seems to contribute to cognition deterioration, but the underlying mechanisms are poorly understood. Moreover, resveratrol (RSV) has been reported to counteract the loss of cognition assoc...

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Autores principales: Sánchez-Melgar, Alejandro, Izquierdo-Ramírez, Pedro José, Palomera-Ávalos, Verónica, Pallàs, Mercè, Albasanz, José Luis, Martín, Mairena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466958/
https://www.ncbi.nlm.nih.gov/pubmed/34578918
http://dx.doi.org/10.3390/nu13093040
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author Sánchez-Melgar, Alejandro
Izquierdo-Ramírez, Pedro José
Palomera-Ávalos, Verónica
Pallàs, Mercè
Albasanz, José Luis
Martín, Mairena
author_facet Sánchez-Melgar, Alejandro
Izquierdo-Ramírez, Pedro José
Palomera-Ávalos, Verónica
Pallàs, Mercè
Albasanz, José Luis
Martín, Mairena
author_sort Sánchez-Melgar, Alejandro
collection PubMed
description Neurodegenerative disorders are devastating diseases in which aging is a major risk factor. High-fat diet (HFD) seems to contribute to cognition deterioration, but the underlying mechanisms are poorly understood. Moreover, resveratrol (RSV) has been reported to counteract the loss of cognition associated with age. Our study aimed to investigate whether the adenosinergic system and plasma membrane cholesterol are modulated by HFD and RSV in the cerebral cortex of C57BL/6J and SAMP8 mice. Results show that HFD induced increased A(1)R and A(2A)R densities in C57BL/6J, whereas this remained unchanged in SAMP8. Higher activity of 5′-Nucleotidase was found as a common effect induced by HFD in both mice strains. Furthermore, the effect of HFD and RSV on A(2B)R density was different depending on the mouse strain. RSV did not clearly counteract the HFD-induced effects on the adenosinergic system. Besides, no changes in free-cholesterol levels were detected in the plasma membrane of cerebral cortex in both strains. Taken together, our data suggest a different modulation of adenosine receptors depending on the mouse strain, not related to changes in plasma membrane cholesterol content.
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spelling pubmed-84669582021-09-27 High-Fat and Resveratrol Supplemented Diets Modulate Adenosine Receptors in the Cerebral Cortex of C57BL/6J and SAMP8 Mice Sánchez-Melgar, Alejandro Izquierdo-Ramírez, Pedro José Palomera-Ávalos, Verónica Pallàs, Mercè Albasanz, José Luis Martín, Mairena Nutrients Article Neurodegenerative disorders are devastating diseases in which aging is a major risk factor. High-fat diet (HFD) seems to contribute to cognition deterioration, but the underlying mechanisms are poorly understood. Moreover, resveratrol (RSV) has been reported to counteract the loss of cognition associated with age. Our study aimed to investigate whether the adenosinergic system and plasma membrane cholesterol are modulated by HFD and RSV in the cerebral cortex of C57BL/6J and SAMP8 mice. Results show that HFD induced increased A(1)R and A(2A)R densities in C57BL/6J, whereas this remained unchanged in SAMP8. Higher activity of 5′-Nucleotidase was found as a common effect induced by HFD in both mice strains. Furthermore, the effect of HFD and RSV on A(2B)R density was different depending on the mouse strain. RSV did not clearly counteract the HFD-induced effects on the adenosinergic system. Besides, no changes in free-cholesterol levels were detected in the plasma membrane of cerebral cortex in both strains. Taken together, our data suggest a different modulation of adenosine receptors depending on the mouse strain, not related to changes in plasma membrane cholesterol content. MDPI 2021-08-30 /pmc/articles/PMC8466958/ /pubmed/34578918 http://dx.doi.org/10.3390/nu13093040 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sánchez-Melgar, Alejandro
Izquierdo-Ramírez, Pedro José
Palomera-Ávalos, Verónica
Pallàs, Mercè
Albasanz, José Luis
Martín, Mairena
High-Fat and Resveratrol Supplemented Diets Modulate Adenosine Receptors in the Cerebral Cortex of C57BL/6J and SAMP8 Mice
title High-Fat and Resveratrol Supplemented Diets Modulate Adenosine Receptors in the Cerebral Cortex of C57BL/6J and SAMP8 Mice
title_full High-Fat and Resveratrol Supplemented Diets Modulate Adenosine Receptors in the Cerebral Cortex of C57BL/6J and SAMP8 Mice
title_fullStr High-Fat and Resveratrol Supplemented Diets Modulate Adenosine Receptors in the Cerebral Cortex of C57BL/6J and SAMP8 Mice
title_full_unstemmed High-Fat and Resveratrol Supplemented Diets Modulate Adenosine Receptors in the Cerebral Cortex of C57BL/6J and SAMP8 Mice
title_short High-Fat and Resveratrol Supplemented Diets Modulate Adenosine Receptors in the Cerebral Cortex of C57BL/6J and SAMP8 Mice
title_sort high-fat and resveratrol supplemented diets modulate adenosine receptors in the cerebral cortex of c57bl/6j and samp8 mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466958/
https://www.ncbi.nlm.nih.gov/pubmed/34578918
http://dx.doi.org/10.3390/nu13093040
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