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Nrf2 and Heme Oxygenase-1 Involvement in Atherosclerosis Related Oxidative Stress

Atherosclerosis remains the underlying process responsible for cardiovascular diseases and the high mortality rates associated. This chronic inflammatory disease progresses with the formation of occlusive atherosclerotic plaques over the inner walls of vascular vessels, with oxidative stress being a...

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Autores principales: Alonso-Piñeiro, Jose Angel, Gonzalez-Rovira, Almudena, Sánchez-Gomar, Ismael, Moreno, Juan Antonio, Durán-Ruiz, Ma Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466960/
https://www.ncbi.nlm.nih.gov/pubmed/34573095
http://dx.doi.org/10.3390/antiox10091463
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author Alonso-Piñeiro, Jose Angel
Gonzalez-Rovira, Almudena
Sánchez-Gomar, Ismael
Moreno, Juan Antonio
Durán-Ruiz, Ma Carmen
author_facet Alonso-Piñeiro, Jose Angel
Gonzalez-Rovira, Almudena
Sánchez-Gomar, Ismael
Moreno, Juan Antonio
Durán-Ruiz, Ma Carmen
author_sort Alonso-Piñeiro, Jose Angel
collection PubMed
description Atherosclerosis remains the underlying process responsible for cardiovascular diseases and the high mortality rates associated. This chronic inflammatory disease progresses with the formation of occlusive atherosclerotic plaques over the inner walls of vascular vessels, with oxidative stress being an important element of this pathology. Oxidation of low-density lipoproteins (ox-LDL) induces endothelial dysfunction, foam cell activation, and inflammatory response, resulting in the formation of fatty streaks in the atherosclerotic wall. With this in mind, different approaches aim to reduce oxidative damage as a strategy to tackle the progression of atherosclerosis. Special attention has been paid in recent years to the transcription factor Nrf2 and its downstream-regulated protein heme oxygenase-1 (HO-1), both known to provide protection against atherosclerotic injury. In the current review, we summarize the involvement of oxidative stress in atherosclerosis, focusing on the role that these antioxidant molecules exert, as well as the potential therapeutic strategies applied to enhance their antioxidant and antiatherogenic properties.
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spelling pubmed-84669602021-09-27 Nrf2 and Heme Oxygenase-1 Involvement in Atherosclerosis Related Oxidative Stress Alonso-Piñeiro, Jose Angel Gonzalez-Rovira, Almudena Sánchez-Gomar, Ismael Moreno, Juan Antonio Durán-Ruiz, Ma Carmen Antioxidants (Basel) Review Atherosclerosis remains the underlying process responsible for cardiovascular diseases and the high mortality rates associated. This chronic inflammatory disease progresses with the formation of occlusive atherosclerotic plaques over the inner walls of vascular vessels, with oxidative stress being an important element of this pathology. Oxidation of low-density lipoproteins (ox-LDL) induces endothelial dysfunction, foam cell activation, and inflammatory response, resulting in the formation of fatty streaks in the atherosclerotic wall. With this in mind, different approaches aim to reduce oxidative damage as a strategy to tackle the progression of atherosclerosis. Special attention has been paid in recent years to the transcription factor Nrf2 and its downstream-regulated protein heme oxygenase-1 (HO-1), both known to provide protection against atherosclerotic injury. In the current review, we summarize the involvement of oxidative stress in atherosclerosis, focusing on the role that these antioxidant molecules exert, as well as the potential therapeutic strategies applied to enhance their antioxidant and antiatherogenic properties. MDPI 2021-09-14 /pmc/articles/PMC8466960/ /pubmed/34573095 http://dx.doi.org/10.3390/antiox10091463 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Alonso-Piñeiro, Jose Angel
Gonzalez-Rovira, Almudena
Sánchez-Gomar, Ismael
Moreno, Juan Antonio
Durán-Ruiz, Ma Carmen
Nrf2 and Heme Oxygenase-1 Involvement in Atherosclerosis Related Oxidative Stress
title Nrf2 and Heme Oxygenase-1 Involvement in Atherosclerosis Related Oxidative Stress
title_full Nrf2 and Heme Oxygenase-1 Involvement in Atherosclerosis Related Oxidative Stress
title_fullStr Nrf2 and Heme Oxygenase-1 Involvement in Atherosclerosis Related Oxidative Stress
title_full_unstemmed Nrf2 and Heme Oxygenase-1 Involvement in Atherosclerosis Related Oxidative Stress
title_short Nrf2 and Heme Oxygenase-1 Involvement in Atherosclerosis Related Oxidative Stress
title_sort nrf2 and heme oxygenase-1 involvement in atherosclerosis related oxidative stress
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466960/
https://www.ncbi.nlm.nih.gov/pubmed/34573095
http://dx.doi.org/10.3390/antiox10091463
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