The HIV-1 capsid and reverse transcription

The viral capsid plays a key role in HIV-1 reverse transcription. Recent studies have demonstrated that the small molecule IP6 dramatically enhances reverse transcription in vitro by stabilizing the viral capsid. Reverse transcription results in marked changes in the biophysical properties of the ca...

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Autores principales: Aiken, Christopher, Rousso, Itay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466977/
https://www.ncbi.nlm.nih.gov/pubmed/34563203
http://dx.doi.org/10.1186/s12977-021-00566-0
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author Aiken, Christopher
Rousso, Itay
author_facet Aiken, Christopher
Rousso, Itay
author_sort Aiken, Christopher
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description The viral capsid plays a key role in HIV-1 reverse transcription. Recent studies have demonstrated that the small molecule IP6 dramatically enhances reverse transcription in vitro by stabilizing the viral capsid. Reverse transcription results in marked changes in the biophysical properties of the capsid, ultimately resulting in its breakage and disassembly. Here we review the research leading to these advances and describe hypotheses for capsid-dependent HIV-1 reverse transcription and a model for reverse transcription-primed HIV-1 uncoating.
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spelling pubmed-84669772021-09-27 The HIV-1 capsid and reverse transcription Aiken, Christopher Rousso, Itay Retrovirology Review The viral capsid plays a key role in HIV-1 reverse transcription. Recent studies have demonstrated that the small molecule IP6 dramatically enhances reverse transcription in vitro by stabilizing the viral capsid. Reverse transcription results in marked changes in the biophysical properties of the capsid, ultimately resulting in its breakage and disassembly. Here we review the research leading to these advances and describe hypotheses for capsid-dependent HIV-1 reverse transcription and a model for reverse transcription-primed HIV-1 uncoating. BioMed Central 2021-09-25 /pmc/articles/PMC8466977/ /pubmed/34563203 http://dx.doi.org/10.1186/s12977-021-00566-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Aiken, Christopher
Rousso, Itay
The HIV-1 capsid and reverse transcription
title The HIV-1 capsid and reverse transcription
title_full The HIV-1 capsid and reverse transcription
title_fullStr The HIV-1 capsid and reverse transcription
title_full_unstemmed The HIV-1 capsid and reverse transcription
title_short The HIV-1 capsid and reverse transcription
title_sort hiv-1 capsid and reverse transcription
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466977/
https://www.ncbi.nlm.nih.gov/pubmed/34563203
http://dx.doi.org/10.1186/s12977-021-00566-0
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