AKT signaling is associated with epigenetic reprogramming via the upregulation of TET and its cofactor, alpha-ketoglutarate during iPSC generation

BACKGROUND: Phosphoinositide-3 kinase (PI3K)/AKT signaling participates in cellular proliferation, survival and tumorigenesis. The activation of AKT signaling promotes the cellular reprogramming including generation of induced pluripotent stem cells (iPSCs) and dedifferentiation of primordial germ c...

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Detalles Bibliográficos
Autores principales: Sekita, Yoichi, Sugiura, Yuki, Matsumoto, Akari, Kawasaki, Yuki, Akasaka, Kazuya, Konno, Ryo, Shimizu, Momoka, Ito, Toshiaki, Sugiyama, Eiji, Yamazaki, Terushi, Kanai, Eriko, Nakamura, Toshinobu, Suematsu, Makoto, Ishino, Fumitoshi, Kodera, Yoshio, Kohda, Takashi, Kimura, Tohru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467031/
https://www.ncbi.nlm.nih.gov/pubmed/34563253
http://dx.doi.org/10.1186/s13287-021-02578-1

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