IL-15 Is Overexpressed in γδ T Cells and Correlates with Disease Severity in Relapsing-Remitting Multiple Sclerosis

Interleukin 15 (IL-15) is known to be involved in the pathogenesis of multiple sclerosis (MS). An animal study revealed a distinct subset of IL-15-producing γδ T cells that correlate with disease severity. The aim of the current study was to test whether such a subset is also present in humans and i...

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Autores principales: Zarobkiewicz, Michał K., Kowalska, Wioleta, Morawska, Izabela, Halczuk, Paweł, Rejdak, Konrad, Bojarska-Junak, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467081/
https://www.ncbi.nlm.nih.gov/pubmed/34575283
http://dx.doi.org/10.3390/jcm10184174
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author Zarobkiewicz, Michał K.
Kowalska, Wioleta
Morawska, Izabela
Halczuk, Paweł
Rejdak, Konrad
Bojarska-Junak, Agnieszka
author_facet Zarobkiewicz, Michał K.
Kowalska, Wioleta
Morawska, Izabela
Halczuk, Paweł
Rejdak, Konrad
Bojarska-Junak, Agnieszka
author_sort Zarobkiewicz, Michał K.
collection PubMed
description Interleukin 15 (IL-15) is known to be involved in the pathogenesis of multiple sclerosis (MS). An animal study revealed a distinct subset of IL-15-producing γδ T cells that correlate with disease severity. The aim of the current study was to test whether such a subset is also present in humans and its importance for the pathogenesis of MS. The peripheral blood from 29 patients with relapsing-remitting MS (including 6 relapses) and 22 controls was stained with monoclonal antibodies and analyzed with flow cytometry. The existence of IL-15+ γδ T cells was confirmed. Moreover, the percentage of IL-15+ γδ T is significantly increased in MS patients and correlates with disease severity. Nevertheless, additional functional studies are needed to fully understand the importance of those cells in multiple sclerosis pathogenesis
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spelling pubmed-84670812021-09-27 IL-15 Is Overexpressed in γδ T Cells and Correlates with Disease Severity in Relapsing-Remitting Multiple Sclerosis Zarobkiewicz, Michał K. Kowalska, Wioleta Morawska, Izabela Halczuk, Paweł Rejdak, Konrad Bojarska-Junak, Agnieszka J Clin Med Article Interleukin 15 (IL-15) is known to be involved in the pathogenesis of multiple sclerosis (MS). An animal study revealed a distinct subset of IL-15-producing γδ T cells that correlate with disease severity. The aim of the current study was to test whether such a subset is also present in humans and its importance for the pathogenesis of MS. The peripheral blood from 29 patients with relapsing-remitting MS (including 6 relapses) and 22 controls was stained with monoclonal antibodies and analyzed with flow cytometry. The existence of IL-15+ γδ T cells was confirmed. Moreover, the percentage of IL-15+ γδ T is significantly increased in MS patients and correlates with disease severity. Nevertheless, additional functional studies are needed to fully understand the importance of those cells in multiple sclerosis pathogenesis MDPI 2021-09-15 /pmc/articles/PMC8467081/ /pubmed/34575283 http://dx.doi.org/10.3390/jcm10184174 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zarobkiewicz, Michał K.
Kowalska, Wioleta
Morawska, Izabela
Halczuk, Paweł
Rejdak, Konrad
Bojarska-Junak, Agnieszka
IL-15 Is Overexpressed in γδ T Cells and Correlates with Disease Severity in Relapsing-Remitting Multiple Sclerosis
title IL-15 Is Overexpressed in γδ T Cells and Correlates with Disease Severity in Relapsing-Remitting Multiple Sclerosis
title_full IL-15 Is Overexpressed in γδ T Cells and Correlates with Disease Severity in Relapsing-Remitting Multiple Sclerosis
title_fullStr IL-15 Is Overexpressed in γδ T Cells and Correlates with Disease Severity in Relapsing-Remitting Multiple Sclerosis
title_full_unstemmed IL-15 Is Overexpressed in γδ T Cells and Correlates with Disease Severity in Relapsing-Remitting Multiple Sclerosis
title_short IL-15 Is Overexpressed in γδ T Cells and Correlates with Disease Severity in Relapsing-Remitting Multiple Sclerosis
title_sort il-15 is overexpressed in γδ t cells and correlates with disease severity in relapsing-remitting multiple sclerosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467081/
https://www.ncbi.nlm.nih.gov/pubmed/34575283
http://dx.doi.org/10.3390/jcm10184174
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