Cargando…

Perilipin 5 Ameliorates Hepatic Stellate Cell Activation via SMAD2/3 and SNAIL Signaling Pathways and Suppresses STAT3 Activation

Comprehending the molecular mechanisms underlying hepatic fibrogenesis is essential to the development of treatment. The hallmark of hepatic fibrosis is the development and deposition of excess fibrous connective tissue forcing tissue remodeling. Hepatic stellate cells (HSC) play a major role in the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cierpka, Rafael, Weiskirchen, Ralf, Asimakopoulos, Anastasia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467115/ https://www.ncbi.nlm.nih.gov/pubmed/34571833 http://dx.doi.org/10.3390/cells10092184

Ejemplares similares

Understanding the Role of Perilipin 5 in Non-Alcoholic Fatty Liver Disease and Its Role in Hepatocellular Carcinoma: A Review of Novel Insights
por: Mass Sanchez, Paola Berenice, et al.
Publicado: (2021)

Perilipin 5 and Lipocalin 2 Expression in Hepatocellular Carcinoma
por: Asimakopoulou, Anastasia, et al.
Publicado: (2019)

Lipid-Independent Regulation of PLIN5 via IL-6 through the JAK/STAT3 Axis in Hep3B Cells
por: Krizanac, Marinela, et al.
Publicado: (2023)

Activation of BK Channels Prevents Hepatic Stellate Cell Activation and Liver Fibrosis Through the Suppression of TGFβ1/SMAD3 and JAK/STAT3 Profibrotic Signaling Pathways
por: Yang, Linli, et al.
Publicado: (2020)

Luteolin-Mediated Inhibition of Hepatic Stellate Cell Activation via Suppression of the STAT3 Pathway
por: Cummins, Claire B., et al.
Publicado: (2018)

Fibroblast Growth Factor–21 ameliorates hepatic encephalopathy by activating the STAT3-SOCS3 pathway to inhibit activated hepatic stellate cells
por: Opoku, Yeboah Kwaku, et al.
Publicado: (2020)

Deletion of Perilipin 5 Protects against Hepatic Injury in Nonalcoholic Fatty Liver Disease via Missing Inflammasome Activation
por: Asimakopoulou, Anastasia, et al.
Publicado: (2020)

The hop constituent xanthohumol exhibits hepatoprotective effects and inhibits the activation of hepatic stellate cells at different levels
por: Weiskirchen, Ralf, et al.
Publicado: (2015)

Pharmacological Intervention in Hepatic Stellate Cell Activation and Hepatic Fibrosis
por: Schon, Hans-Theo, et al.
Publicado: (2016)

Immortal hepatic stellate cell lines: useful tools to study hepatic stellate cell biology and function?
por: Herrmann, Jens, et al.
Publicado: (2007)

S-Adenosylmethionine suppresses the expression of Smad3/4 in activated human hepatic stellate cells via Rac1 promoter methylation
por: BIAN, KANGQI, et al.
Publicado: (2016)

Salidroside ameliorates autophagy and activation of hepatic stellate cells in mice via NF-κB and TGF-β1/Smad3 pathways
por: Feng, Jiao, et al.
Publicado: (2018)

SIRT6 Protects Against Liver Fibrosis by Deacetylation and Suppression of SMAD3 in Hepatic Stellate Cells
por: Zhong, Xiaolin, et al.
Publicado: (2020)

Yao medicine Amydrium hainanense suppresses hepatic fibrosis by repressing hepatic stellate cell activation via STAT3 signaling
por: Wu, Bingmin, et al.
Publicado: (2022)

Suppressive effect of microRNA‐29b on hepatic stellate cell activation and its crosstalk with TGF‐β1/Smad3
por: Liang, Chunli, et al.
Publicado: (2016)

Interleukin-27 acts on hepatic stellate cells and induces signal transducer and activator of transcription 1-dependent responses
por: Schoenherr, Caroline, et al.
Publicado: (2010)

Clusterin Attenuates Hepatic Fibrosis by Inhibiting Hepatic Stellate Cell Activation and Downregulating the Smad3 Signaling Pathway
por: Seo, Hye-Young, et al.
Publicado: (2019)

(–)-Catechin-7-O-β-d-Apiofuranoside Inhibits Hepatic Stellate Cell Activation by Suppressing the STAT3 Signaling Pathway
por: Park, Yong Joo, et al.
Publicado: (2019)

Perilipin 2 Protects against Lipotoxicity-Induced Islet Fibrosis by Inducing Islet Stellate Cell Activation Phenotype Changes
por: Zhou, Yunting, et al.
Publicado: (2022)

Inhibitory Smads suppress pancreatic stellate cell activation through negative feedback in chronic pancreatitis
por: Lin, Hao, et al.
Publicado: (2021)

Imaging cytoplasmic lipid droplets in vivo with fluorescent perilipin 2 and perilipin 3 knock-in zebrafish
por: Wilson, Meredith H, et al.
Publicado: (2021)

Magnesium Isoglycyrrhizinate Ameliorates Fibrosis and Disrupts TGF-β-Mediated SMAD Pathway in Activated Hepatic Stellate Cell Line LX2
por: Tee, Jie Kai, et al.
Publicado: (2018)

Correction: Imaging cytoplasmic lipid droplets in vivo with fluorescent perilipin 2 and perilipin 3 knock-in zebrafish
por: Wilson, Meredith H, et al.
Publicado: (2023)

Targeting Activated Hepatic Stellate Cells Using Collagen-Binding Chitosan Nanoparticles for siRNA Delivery to Fibrotic Livers
por: Azzam, Menna, et al.
Publicado: (2020)

Tetramethylpyrazine inhibits CTGF and Smad2/3 expression and proliferation of hepatic stellate cells
por: Li, Jun, et al.
Publicado: (2015)

MicroRNA-195 Activates Hepatic Stellate Cells In Vitro by Targeting Smad7
por: Song, Li-Ying, et al.
Publicado: (2017)

Osthole ameliorates hepatic fibrosis and inhibits hepatic stellate cell activation
por: Liu, Ya-Wei, et al.
Publicado: (2015)

Eupatilin Ameliorates Hepatic Fibrosis and Hepatic Stellate Cell Activation by Suppressing β-catenin/PAI-1 Pathway
por: Hu, Jinyuan, et al.
Publicado: (2023)

Aqueous extract of Amydrium sinense (Engl.) H. Li alleviates hepatic fibrosis by suppressing hepatic stellate cell activation through inhibiting Stat3 signaling
por: Li, Jingyan, et al.
Publicado: (2023)

Pharmacological inhibition of STAT3 pathway ameliorates acute liver injury in vivo via inactivation of inflammatory macrophages and hepatic stellate cells
por: Öztürk Akcora, Büsra, et al.
Publicado: (2020)

Comparative evaluation of gene delivery devices in primary cultures of rat hepatic stellate cells and rat myofibroblasts
por: Weiskirchen, Ralf, et al.
Publicado: (2000)

Both MAPK and STAT3 signal transduction pathways are necessary for IL-6-dependent hepatic stellate cells activation
por: Kagan, Polina, et al.
Publicado: (2017)

Nrf2 protects stellate cells from Smad-dependent cell activation
por: Prestigiacomo, Vincenzo, et al.
Publicado: (2018)

Hepcidin inhibits Smad3 phosphorylation in hepatic stellate cells by impeding ferroportin-mediated regulation of Akt
por: Han, Chang Yeob, et al.
Publicado: (2016)

Apamin suppresses biliary fibrosis and activation of hepatic stellate cells
por: Kim, Jung-Yeon, et al.
Publicado: (2017)

Multiplex short tandem repeat profiling of immortalized hepatic stellate cell line Col-GFP HSC
por: Meurer, Steffen K., et al.
Publicado: (2022)

JAK/STAT3 and Smad3 activities are required for the wound healing properties of Periplaneta americana extracts
por: Song, Qin, et al.
Publicado: (2017)

3D hESC exosomes enriched with miR-6766-3p ameliorates liver fibrosis by attenuating activated stellate cells through targeting the TGFβRII-SMADS pathway
por: Wang, Ning, et al.
Publicado: (2021)

rSjP40 suppresses hepatic stellate cell activation by promoting microRNA‐155 expression and inhibiting STAT5 and FOXO3a expression
por: Zhu, Dandan, et al.
Publicado: (2018)

A Scoping Review on Lipocalin-2 and Its Role in Non-Alcoholic Steatohepatitis and Hepatocellular Carcinoma
por: Krizanac, Marinela, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_e5vgl43jv0pa30upuddqev5e73