Targeting the Bromodomain of BRG-1/BRM Subunit of the SWI/SNF Complex Increases the Anticancer Activity of Temozolomide in Glioblastoma

Glioblastoma (GBM) is a deadly and incurable brain cancer with limited therapeutic options. PFI-3 is a small-molecule bromodomain (BRD) inhibitor of the BRM/BRG1 subunits of the SWI/SNF chromatin remodeling complex. The objective of this study is to determine the efficacy of PFI-3 as a potential GBM...

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Detalles Bibliográficos
Autores principales: Yang, Chuanhe, Wang, Yinan, Sims, Michelle M., He, Yali, Miller, Duane D., Pfeffer, Lawrence M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467157/
https://www.ncbi.nlm.nih.gov/pubmed/34577604
http://dx.doi.org/10.3390/ph14090904

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467157/
https://www.ncbi.nlm.nih.gov/pubmed/34577604
http://dx.doi.org/10.3390/ph14090904

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