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Anticancer Potential of Natural Bark Products—A Review

Cell biology, plant-based extracts, structural chemistry, and laboratory in vitro or in vivo experiments are the principal aspects or interfaces that can contribute to discovering new possibilities in cancer therapy and to developing improved chemotherapeutics. Forestry residues can be used for thei...

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Autores principales: Burlacu, Ema, Tanase, Corneliu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467168/
https://www.ncbi.nlm.nih.gov/pubmed/34579427
http://dx.doi.org/10.3390/plants10091895
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author Burlacu, Ema
Tanase, Corneliu
author_facet Burlacu, Ema
Tanase, Corneliu
author_sort Burlacu, Ema
collection PubMed
description Cell biology, plant-based extracts, structural chemistry, and laboratory in vitro or in vivo experiments are the principal aspects or interfaces that can contribute to discovering new possibilities in cancer therapy and to developing improved chemotherapeutics. Forestry residues can be used for their wealthy resource in polyphenols and other phytoconstituents known for anticancer properties. This review is designed to bring together information on the in vitro or in vivo anticancer potential of woody vascular plants especially the bark extracts (BE) and biosynthesized metallic nanoparticles (BMN) using bark extracts. Type of extracts, main phytoconstituents found in extracts responsible for the anticancer activity, and targeted cancerous cell lines were followed. The literature data were collected via Clarivate Analytics, Science Direct, PubMed, and Google Academic (2011–2021). The search terms were: bark extracts, metallic nanoparticles, silver nanoparticles, gold nanoparticles, anticancer, cytotoxic activity, antiproliferative effect, and antimetastatic potential in vitro and in vivo. All of the search terms listed above were used in different combinations. The literature data highlight the efficaciousness of the BE and BMN as anticancer agents in in vitro experiments and showed the mechanism of action and their advantage of nontoxicity on normal cells. In vitro testing has shown promising results of the BE and BMN effect on different cancer cell lines. In vivo testing is lacking and more data is necessary for drug development on animal models.
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spelling pubmed-84671682021-09-27 Anticancer Potential of Natural Bark Products—A Review Burlacu, Ema Tanase, Corneliu Plants (Basel) Review Cell biology, plant-based extracts, structural chemistry, and laboratory in vitro or in vivo experiments are the principal aspects or interfaces that can contribute to discovering new possibilities in cancer therapy and to developing improved chemotherapeutics. Forestry residues can be used for their wealthy resource in polyphenols and other phytoconstituents known for anticancer properties. This review is designed to bring together information on the in vitro or in vivo anticancer potential of woody vascular plants especially the bark extracts (BE) and biosynthesized metallic nanoparticles (BMN) using bark extracts. Type of extracts, main phytoconstituents found in extracts responsible for the anticancer activity, and targeted cancerous cell lines were followed. The literature data were collected via Clarivate Analytics, Science Direct, PubMed, and Google Academic (2011–2021). The search terms were: bark extracts, metallic nanoparticles, silver nanoparticles, gold nanoparticles, anticancer, cytotoxic activity, antiproliferative effect, and antimetastatic potential in vitro and in vivo. All of the search terms listed above were used in different combinations. The literature data highlight the efficaciousness of the BE and BMN as anticancer agents in in vitro experiments and showed the mechanism of action and their advantage of nontoxicity on normal cells. In vitro testing has shown promising results of the BE and BMN effect on different cancer cell lines. In vivo testing is lacking and more data is necessary for drug development on animal models. MDPI 2021-09-13 /pmc/articles/PMC8467168/ /pubmed/34579427 http://dx.doi.org/10.3390/plants10091895 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Burlacu, Ema
Tanase, Corneliu
Anticancer Potential of Natural Bark Products—A Review
title Anticancer Potential of Natural Bark Products—A Review
title_full Anticancer Potential of Natural Bark Products—A Review
title_fullStr Anticancer Potential of Natural Bark Products—A Review
title_full_unstemmed Anticancer Potential of Natural Bark Products—A Review
title_short Anticancer Potential of Natural Bark Products—A Review
title_sort anticancer potential of natural bark products—a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467168/
https://www.ncbi.nlm.nih.gov/pubmed/34579427
http://dx.doi.org/10.3390/plants10091895
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