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Novel Photonic Bio-Chip Sensor Based on Strained Graphene Sheets for Blood Cell Sorting
A photonic biochip with a tunable response in the visible range is suggested for blood cell sorting applications. Multi-layers of ZnS and Ge slabs (as the main building blocks), hosting a cell in which bio-sample could be injected, are considered as the core of the sensor. In order to increase the s...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467184/ https://www.ncbi.nlm.nih.gov/pubmed/34577055 http://dx.doi.org/10.3390/molecules26185585 |
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author | Ghasemi, Fatemeh Razi, Sepehr |
author_facet | Ghasemi, Fatemeh Razi, Sepehr |
author_sort | Ghasemi, Fatemeh |
collection | PubMed |
description | A photonic biochip with a tunable response in the visible range is suggested for blood cell sorting applications. Multi-layers of ZnS and Ge slabs (as the main building blocks), hosting a cell in which bio-sample could be injected, are considered as the core of the sensor. In order to increase the sensitivity of the chip, the bio-cell is capsulated inside air slabs, and its walls are coated with graphene sheets. Paying special attention to white and red blood components, the optimum values for structural parameters are extracted first. Tunability of the sensor detectivity is then explored by finding the role of the probe light incident angle, as well as its polarization. The strain of the graphene layer and angle in which it is applied are also suggested to further improve the performance tunability. Results reflect that the biochip can effectively identify selected components through their induced different optical features, besides of the different figure of merit and sensitivity amounts that are recorded for them by the sensor. |
format | Online Article Text |
id | pubmed-8467184 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84671842021-09-27 Novel Photonic Bio-Chip Sensor Based on Strained Graphene Sheets for Blood Cell Sorting Ghasemi, Fatemeh Razi, Sepehr Molecules Article A photonic biochip with a tunable response in the visible range is suggested for blood cell sorting applications. Multi-layers of ZnS and Ge slabs (as the main building blocks), hosting a cell in which bio-sample could be injected, are considered as the core of the sensor. In order to increase the sensitivity of the chip, the bio-cell is capsulated inside air slabs, and its walls are coated with graphene sheets. Paying special attention to white and red blood components, the optimum values for structural parameters are extracted first. Tunability of the sensor detectivity is then explored by finding the role of the probe light incident angle, as well as its polarization. The strain of the graphene layer and angle in which it is applied are also suggested to further improve the performance tunability. Results reflect that the biochip can effectively identify selected components through their induced different optical features, besides of the different figure of merit and sensitivity amounts that are recorded for them by the sensor. MDPI 2021-09-14 /pmc/articles/PMC8467184/ /pubmed/34577055 http://dx.doi.org/10.3390/molecules26185585 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ghasemi, Fatemeh Razi, Sepehr Novel Photonic Bio-Chip Sensor Based on Strained Graphene Sheets for Blood Cell Sorting |
title | Novel Photonic Bio-Chip Sensor Based on Strained Graphene Sheets for Blood Cell Sorting |
title_full | Novel Photonic Bio-Chip Sensor Based on Strained Graphene Sheets for Blood Cell Sorting |
title_fullStr | Novel Photonic Bio-Chip Sensor Based on Strained Graphene Sheets for Blood Cell Sorting |
title_full_unstemmed | Novel Photonic Bio-Chip Sensor Based on Strained Graphene Sheets for Blood Cell Sorting |
title_short | Novel Photonic Bio-Chip Sensor Based on Strained Graphene Sheets for Blood Cell Sorting |
title_sort | novel photonic bio-chip sensor based on strained graphene sheets for blood cell sorting |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467184/ https://www.ncbi.nlm.nih.gov/pubmed/34577055 http://dx.doi.org/10.3390/molecules26185585 |
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