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Polysaccharides as Stabilizers for Polymeric Microcarriers Fabrication
Biodegradable polymeric microparticles are widely used in drug delivery systems with prolonged-release profiles and/or cell microcarriers. Their fabrication via the oil/water emulsion solvent evaporation technique has normally required emulsifiers in the aqueous phase. The present work aims to evalu...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467260/ https://www.ncbi.nlm.nih.gov/pubmed/34577945 http://dx.doi.org/10.3390/polym13183045 |
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author | Demina, Tatiana S. Kilyashova, Liubov A. Popyrina, Tatiana N. Svidchenko, Eugenia A. Bhuniya, Sankarprasad Akopova, Tatiana A. Grandfils, Christian |
author_facet | Demina, Tatiana S. Kilyashova, Liubov A. Popyrina, Tatiana N. Svidchenko, Eugenia A. Bhuniya, Sankarprasad Akopova, Tatiana A. Grandfils, Christian |
author_sort | Demina, Tatiana S. |
collection | PubMed |
description | Biodegradable polymeric microparticles are widely used in drug delivery systems with prolonged-release profiles and/or cell microcarriers. Their fabrication via the oil/water emulsion solvent evaporation technique has normally required emulsifiers in the aqueous phase. The present work aims to evaluate the effectiveness of various polysaccharides, such as chitosan, hyaluronic acid, cellulose, arabinogalactan, guar and their derivatives, as an alternative to synthetic surfactants for polylactide microparticle stabilization during their fabrication. Targeted modification of the biopolymer’s chemical structure was also tested as a tool to enhance polysaccharides’ emulsifying ability. The transformation of biomacromolecules into a form of nanoparticle via bottom-up or top-down methods and their subsequent application for microparticle fabrication via the Pickering emulsion solvent evaporation technique was useful as a one-step approach towards the preparation of core/shell microparticles. The effect of polysaccharides’ chemical structure and the form of their application on the polylactide microparticles’ total yield, size distribution and morphology was evaluated. The application of polysaccharides has great potential in terms of the development of green chemistry and the biocompatibility of the formed microparticles, which is especially important in biomedicine application. |
format | Online Article Text |
id | pubmed-8467260 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84672602021-09-27 Polysaccharides as Stabilizers for Polymeric Microcarriers Fabrication Demina, Tatiana S. Kilyashova, Liubov A. Popyrina, Tatiana N. Svidchenko, Eugenia A. Bhuniya, Sankarprasad Akopova, Tatiana A. Grandfils, Christian Polymers (Basel) Article Biodegradable polymeric microparticles are widely used in drug delivery systems with prolonged-release profiles and/or cell microcarriers. Their fabrication via the oil/water emulsion solvent evaporation technique has normally required emulsifiers in the aqueous phase. The present work aims to evaluate the effectiveness of various polysaccharides, such as chitosan, hyaluronic acid, cellulose, arabinogalactan, guar and their derivatives, as an alternative to synthetic surfactants for polylactide microparticle stabilization during their fabrication. Targeted modification of the biopolymer’s chemical structure was also tested as a tool to enhance polysaccharides’ emulsifying ability. The transformation of biomacromolecules into a form of nanoparticle via bottom-up or top-down methods and their subsequent application for microparticle fabrication via the Pickering emulsion solvent evaporation technique was useful as a one-step approach towards the preparation of core/shell microparticles. The effect of polysaccharides’ chemical structure and the form of their application on the polylactide microparticles’ total yield, size distribution and morphology was evaluated. The application of polysaccharides has great potential in terms of the development of green chemistry and the biocompatibility of the formed microparticles, which is especially important in biomedicine application. MDPI 2021-09-09 /pmc/articles/PMC8467260/ /pubmed/34577945 http://dx.doi.org/10.3390/polym13183045 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Demina, Tatiana S. Kilyashova, Liubov A. Popyrina, Tatiana N. Svidchenko, Eugenia A. Bhuniya, Sankarprasad Akopova, Tatiana A. Grandfils, Christian Polysaccharides as Stabilizers for Polymeric Microcarriers Fabrication |
title | Polysaccharides as Stabilizers for Polymeric Microcarriers Fabrication |
title_full | Polysaccharides as Stabilizers for Polymeric Microcarriers Fabrication |
title_fullStr | Polysaccharides as Stabilizers for Polymeric Microcarriers Fabrication |
title_full_unstemmed | Polysaccharides as Stabilizers for Polymeric Microcarriers Fabrication |
title_short | Polysaccharides as Stabilizers for Polymeric Microcarriers Fabrication |
title_sort | polysaccharides as stabilizers for polymeric microcarriers fabrication |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467260/ https://www.ncbi.nlm.nih.gov/pubmed/34577945 http://dx.doi.org/10.3390/polym13183045 |
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