Markov State Models and Molecular Dynamics Simulations Provide Understanding of the Nucleotide-Dependent Dimerization-Based Activation of LRRK2 ROC Domain

Mutations in leucine-rich repeat kinase 2 (LRRK2) are recognized as the most frequent cause of Parkinson’s disease (PD). As a multidomain ROCO protein, LRRK2 is characterized by the presence of both a Ras-of-complex (ROC) GTPase domain and a kinase domain connected through the C-terminal of an ROC d...

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Detalles Bibliográficos
Autores principales: Li, Xinyi, Qi, Zengxin, Ni, Duan, Lu, Shaoyong, Chen, Liang, Chen, Xiangyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467336/
https://www.ncbi.nlm.nih.gov/pubmed/34577121
http://dx.doi.org/10.3390/molecules26185647

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467336/
https://www.ncbi.nlm.nih.gov/pubmed/34577121
http://dx.doi.org/10.3390/molecules26185647

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