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Pomegranate Juice Ameliorates Dopamine Release and Behavioral Deficits in a Rat Model of Parkinson’s Disease

Pomegranate juice (PJ) is a rich source of ellagitannins (ETs), precursors of colonic metabolite urolithin A, which are believed to contribute to pomegranate’s neuroprotective effect. While many experimental studies involving PJ’s role in Alzheimer’s disease and hypoxic-ischemic brain injury have be...

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Autores principales: Kujawska, Małgorzata, Jourdes, Michael, Witucki, Łukasz, Karaźniewicz-Łada, Marta, Szulc, Michał, Górska, Agata, Mikołajczak, Przemysław Ł., Teissedre, Pierre-Louis, Jodynis-Liebert, Jadwiga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467386/
https://www.ncbi.nlm.nih.gov/pubmed/34573149
http://dx.doi.org/10.3390/brainsci11091127
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author Kujawska, Małgorzata
Jourdes, Michael
Witucki, Łukasz
Karaźniewicz-Łada, Marta
Szulc, Michał
Górska, Agata
Mikołajczak, Przemysław Ł.
Teissedre, Pierre-Louis
Jodynis-Liebert, Jadwiga
author_facet Kujawska, Małgorzata
Jourdes, Michael
Witucki, Łukasz
Karaźniewicz-Łada, Marta
Szulc, Michał
Górska, Agata
Mikołajczak, Przemysław Ł.
Teissedre, Pierre-Louis
Jodynis-Liebert, Jadwiga
author_sort Kujawska, Małgorzata
collection PubMed
description Pomegranate juice (PJ) is a rich source of ellagitannins (ETs), precursors of colonic metabolite urolithin A, which are believed to contribute to pomegranate’s neuroprotective effect. While many experimental studies involving PJ’s role in Alzheimer’s disease and hypoxic-ischemic brain injury have been conducted, our knowledge of pomegranate’s effects against Parkinson’s disease (PD) is very limited. Previously, we have reported that PJ treatment improved postural stability, which correlated well with enhancement of neuronal survival, protection against oxidative damage, and α-synuclein aggregation. Since olfactory and motor deficits are typical symptoms of PD, in this study, we aimed to investigate the capability of PJ to protect against olfactory, motoric, and neurochemical alterations. To evaluate its efficiency, Wistar rats were given a combined treatment with ROT (1.3 mg/kg b.w./day, s.c.) and PJ (500 mg/kg/day, p.o.) for 35 days. After this, we assessed the olfactory discrimination index (DI) and vertical and horizontal activities as well as levels of dopamine and its main metabolite 3,4-Dihydroxyphenylacetic acid (DOPAC) in the dissected midbrain of animals. Our findings provide the first evidence that PJ treatment protects against ROT-induced DA depletion in the midbrain, which correlates well with improved olfactory function and vertical activity as well as with the presence of urolithin A in the brain.
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spelling pubmed-84673862021-09-27 Pomegranate Juice Ameliorates Dopamine Release and Behavioral Deficits in a Rat Model of Parkinson’s Disease Kujawska, Małgorzata Jourdes, Michael Witucki, Łukasz Karaźniewicz-Łada, Marta Szulc, Michał Górska, Agata Mikołajczak, Przemysław Ł. Teissedre, Pierre-Louis Jodynis-Liebert, Jadwiga Brain Sci Article Pomegranate juice (PJ) is a rich source of ellagitannins (ETs), precursors of colonic metabolite urolithin A, which are believed to contribute to pomegranate’s neuroprotective effect. While many experimental studies involving PJ’s role in Alzheimer’s disease and hypoxic-ischemic brain injury have been conducted, our knowledge of pomegranate’s effects against Parkinson’s disease (PD) is very limited. Previously, we have reported that PJ treatment improved postural stability, which correlated well with enhancement of neuronal survival, protection against oxidative damage, and α-synuclein aggregation. Since olfactory and motor deficits are typical symptoms of PD, in this study, we aimed to investigate the capability of PJ to protect against olfactory, motoric, and neurochemical alterations. To evaluate its efficiency, Wistar rats were given a combined treatment with ROT (1.3 mg/kg b.w./day, s.c.) and PJ (500 mg/kg/day, p.o.) for 35 days. After this, we assessed the olfactory discrimination index (DI) and vertical and horizontal activities as well as levels of dopamine and its main metabolite 3,4-Dihydroxyphenylacetic acid (DOPAC) in the dissected midbrain of animals. Our findings provide the first evidence that PJ treatment protects against ROT-induced DA depletion in the midbrain, which correlates well with improved olfactory function and vertical activity as well as with the presence of urolithin A in the brain. MDPI 2021-08-25 /pmc/articles/PMC8467386/ /pubmed/34573149 http://dx.doi.org/10.3390/brainsci11091127 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kujawska, Małgorzata
Jourdes, Michael
Witucki, Łukasz
Karaźniewicz-Łada, Marta
Szulc, Michał
Górska, Agata
Mikołajczak, Przemysław Ł.
Teissedre, Pierre-Louis
Jodynis-Liebert, Jadwiga
Pomegranate Juice Ameliorates Dopamine Release and Behavioral Deficits in a Rat Model of Parkinson’s Disease
title Pomegranate Juice Ameliorates Dopamine Release and Behavioral Deficits in a Rat Model of Parkinson’s Disease
title_full Pomegranate Juice Ameliorates Dopamine Release and Behavioral Deficits in a Rat Model of Parkinson’s Disease
title_fullStr Pomegranate Juice Ameliorates Dopamine Release and Behavioral Deficits in a Rat Model of Parkinson’s Disease
title_full_unstemmed Pomegranate Juice Ameliorates Dopamine Release and Behavioral Deficits in a Rat Model of Parkinson’s Disease
title_short Pomegranate Juice Ameliorates Dopamine Release and Behavioral Deficits in a Rat Model of Parkinson’s Disease
title_sort pomegranate juice ameliorates dopamine release and behavioral deficits in a rat model of parkinson’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467386/
https://www.ncbi.nlm.nih.gov/pubmed/34573149
http://dx.doi.org/10.3390/brainsci11091127
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