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Numerical Optimization of an Open-Ended Coaxial Slot Applicator for the Detection and Microwave Ablation of Tumors

SIMPLE SUMMARY: In this work, a parametric analysis of a dual-mode applicator for microwave ablation treatments is proposed to optimize the geometric parameters of the structure. The dual-mode concept means that the applicator comprises an additional sensing mode to determine the dielectric properti...

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Autores principales: Hessinger, Carolin, Schüßler, Martin, Klos, Sabrina, Kochanek, Markus, Jakoby, Rolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467388/
https://www.ncbi.nlm.nih.gov/pubmed/34571791
http://dx.doi.org/10.3390/biology10090914
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author Hessinger, Carolin
Schüßler, Martin
Klos, Sabrina
Kochanek, Markus
Jakoby, Rolf
author_facet Hessinger, Carolin
Schüßler, Martin
Klos, Sabrina
Kochanek, Markus
Jakoby, Rolf
author_sort Hessinger, Carolin
collection PubMed
description SIMPLE SUMMARY: In this work, a parametric analysis of a dual-mode applicator for microwave ablation treatments is proposed to optimize the geometric parameters of the structure. The dual-mode concept means that the applicator comprises an additional sensing mode to determine the dielectric properties of the surrounding tissue before and during the ablation procedure. Based on numerical electromagnetic-thermal coupled simulations the most optimal design in terms of applicator efficiency as well as ablation zone volume and shape is determined that further fulfills the sensitivity requirements of the sensing mode. The multiobjective optimization problem is solved graphically with the so-called Pareto-optimization method. The resulting Pareto-optimal dual-mode applicator designs are characterized by electromagnetic and thermal simulations and discussed. ABSTRACT: A multiobjective optimization method for a dual-mode microwave applicator is proposed. Dual-modality means that microwaves are used apart from the treatment, and also for the monitoring of the microwave ablation intervention. (1) The use of computational models to develop and improve microwave ablation applicator geometries is essential for further advances in this field. (2) Numerical electromagnetic–thermal coupled simulation models are used to analyze the performance of the dual-mode applicator in liver tissue; the sensitivity evaluation of the dual-mode applicator’s sensing mode constrains the set of optimal solutions. (3) Three Pareto-optimal design parameter sets are derived that are optimal in terms of applicator efficiency as well as volume and sphericity of the ablation zone. The resulting designs of the dual-mode applicator provide a suitable sensitivity to distinguish between healthy and tumorous liver tissue. (4) The optimized designs are presented and numerically characterized. An improvement on the performance of previously proposed dual-mode applicator designs is achieved. The multiphysical simulation model of electromagnetic and thermal properties of the applicator is applicable for future comprehensive design procedures.
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spelling pubmed-84673882021-09-27 Numerical Optimization of an Open-Ended Coaxial Slot Applicator for the Detection and Microwave Ablation of Tumors Hessinger, Carolin Schüßler, Martin Klos, Sabrina Kochanek, Markus Jakoby, Rolf Biology (Basel) Article SIMPLE SUMMARY: In this work, a parametric analysis of a dual-mode applicator for microwave ablation treatments is proposed to optimize the geometric parameters of the structure. The dual-mode concept means that the applicator comprises an additional sensing mode to determine the dielectric properties of the surrounding tissue before and during the ablation procedure. Based on numerical electromagnetic-thermal coupled simulations the most optimal design in terms of applicator efficiency as well as ablation zone volume and shape is determined that further fulfills the sensitivity requirements of the sensing mode. The multiobjective optimization problem is solved graphically with the so-called Pareto-optimization method. The resulting Pareto-optimal dual-mode applicator designs are characterized by electromagnetic and thermal simulations and discussed. ABSTRACT: A multiobjective optimization method for a dual-mode microwave applicator is proposed. Dual-modality means that microwaves are used apart from the treatment, and also for the monitoring of the microwave ablation intervention. (1) The use of computational models to develop and improve microwave ablation applicator geometries is essential for further advances in this field. (2) Numerical electromagnetic–thermal coupled simulation models are used to analyze the performance of the dual-mode applicator in liver tissue; the sensitivity evaluation of the dual-mode applicator’s sensing mode constrains the set of optimal solutions. (3) Three Pareto-optimal design parameter sets are derived that are optimal in terms of applicator efficiency as well as volume and sphericity of the ablation zone. The resulting designs of the dual-mode applicator provide a suitable sensitivity to distinguish between healthy and tumorous liver tissue. (4) The optimized designs are presented and numerically characterized. An improvement on the performance of previously proposed dual-mode applicator designs is achieved. The multiphysical simulation model of electromagnetic and thermal properties of the applicator is applicable for future comprehensive design procedures. MDPI 2021-09-14 /pmc/articles/PMC8467388/ /pubmed/34571791 http://dx.doi.org/10.3390/biology10090914 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hessinger, Carolin
Schüßler, Martin
Klos, Sabrina
Kochanek, Markus
Jakoby, Rolf
Numerical Optimization of an Open-Ended Coaxial Slot Applicator for the Detection and Microwave Ablation of Tumors
title Numerical Optimization of an Open-Ended Coaxial Slot Applicator for the Detection and Microwave Ablation of Tumors
title_full Numerical Optimization of an Open-Ended Coaxial Slot Applicator for the Detection and Microwave Ablation of Tumors
title_fullStr Numerical Optimization of an Open-Ended Coaxial Slot Applicator for the Detection and Microwave Ablation of Tumors
title_full_unstemmed Numerical Optimization of an Open-Ended Coaxial Slot Applicator for the Detection and Microwave Ablation of Tumors
title_short Numerical Optimization of an Open-Ended Coaxial Slot Applicator for the Detection and Microwave Ablation of Tumors
title_sort numerical optimization of an open-ended coaxial slot applicator for the detection and microwave ablation of tumors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467388/
https://www.ncbi.nlm.nih.gov/pubmed/34571791
http://dx.doi.org/10.3390/biology10090914
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