Conceptual Design of a Novel Nozzle Combined with a Clinical Proton Linac for Magnetically Focussed Minibeams

SIMPLE SUMMARY: Proton minibeam radiation therapy (pMBRT) is a novel therapeutic strategy that combines the tissue sparing potential of submillimetric, spatially fractionated beams (minibeams) with the improved ballistics of protons to enhance the tolerance of normal tissue and allow a dose escalation in the tumour. This approach could allow a more effective treatment of radioresistant tumours and has already shown excellent results for rat gliomas. To exploit the full potential of pMBRT, it should be delivered using magnetically focussed and scanned minibeams. However, such an implementation has not yet been demonstrated at clinically relevant beam energies. In this work, we therefore present a new design combining our recently developed minibeam nozzle with the first clinical proton linear accelerator. We show the suitability of this combination for the generation of magnetically focussed and scanned minibeams with clinically relevant parameters as well as for the delivery of conventional pencil beam scanning techniques. ABSTRACT: (1) Background: Proton minibeam radiation therapy (pMBRT) is a novel therapeutic approach with the potential to significantly increase normal tissue sparing while providing tumour control equivalent or superior to standard proton therapy. For reasons of efficiency, flexibility and minibeam quality, the optimal implementation of pMBRT should use magnetically focussed minibeams which, however, could not yet be generated in a clinical environment. In this study, we evaluated our recently proposed minibeam nozzle together with a new clinical proton linac as a potential implementation. (2) Methods: Monte Carlo simulations were performed to determine under which conditions minibeams can be generated and to evaluate the robustness against focussing magnet errors. Moreover, an example of conventional pencil beam scanning irradiation was simulated. (3) Results: Excellent minibeam sizes between 0.6 and 0.9 mm full width at half maximum could be obtained and a good tolerance to errors was observed. Furthermore, the delivery of a 10 cm × 10 cm field with pencil beams was demonstrated. (4) Conclusion: The combination of the new proton linac and minibeam nozzle could represent an optimal implementation of pMBRT by allowing the generation of magnetically focussed minibeams with clinically relevant parameters. It could furthermore be used for conventional pencil beam scanning.