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Novel Serum and Urinary Metabolites Associated with Diabetic Retinopathy in Three Asian Cohorts

Diabetic retinopathy (DR) is a microvascular complication of diabetes mellitus, a metabolic disorder, but understanding of its pathophysiology remains incomplete. Meta-analysis of three population-based cross-sectional studies (2004–11) representing three major Asian ethnic groups (aged 40–80 years:...

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Autores principales: Quek, Debra Q. Y., He, Feng, Sultana, Rehena, Banu, Riswana, Chee, Miao Li, Nusinovici, Simon, Thakur, Sahil, Qian, Chaoxu, Cheng, Ching-Yu, Wong, Tien Y., Sabanayagam, Charumathi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467425/
https://www.ncbi.nlm.nih.gov/pubmed/34564429
http://dx.doi.org/10.3390/metabo11090614
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author Quek, Debra Q. Y.
He, Feng
Sultana, Rehena
Banu, Riswana
Chee, Miao Li
Nusinovici, Simon
Thakur, Sahil
Qian, Chaoxu
Cheng, Ching-Yu
Wong, Tien Y.
Sabanayagam, Charumathi
author_facet Quek, Debra Q. Y.
He, Feng
Sultana, Rehena
Banu, Riswana
Chee, Miao Li
Nusinovici, Simon
Thakur, Sahil
Qian, Chaoxu
Cheng, Ching-Yu
Wong, Tien Y.
Sabanayagam, Charumathi
author_sort Quek, Debra Q. Y.
collection PubMed
description Diabetic retinopathy (DR) is a microvascular complication of diabetes mellitus, a metabolic disorder, but understanding of its pathophysiology remains incomplete. Meta-analysis of three population-based cross-sectional studies (2004–11) representing three major Asian ethnic groups (aged 40–80 years: Chinese, 592; Malays, 1052; Indians, 1320) was performed. A panel of 228 serum/plasma metabolites and 54 urinary metabolites were quantified using nuclear magnetic resonance (NMR) spectroscopy. Main outcomes were defined as any DR, moderate/above DR, and vision-threatening DR assessed from retinal photographs. The relationship between metabolites and DR outcomes was assessed using multivariate logistic regression models, and metabolites significant after Bonferroni correction were meta-analyzed. Among serum/plasma metabolites, lower levels of tyrosine and cholesterol esters to total lipids ratio in IDL and higher levels of creatinine were positively associated with all three outcomes of DR (all p < 0.005). Among urinary metabolites, lower levels of citrate, ethanolamine, formate, and hypoxanthine were positively associated with all three DR outcomes (all p < 0.005). Higher levels of serum/plasma 3-hydroxybutyrate and lower levels of urinary 3-hydroxyisobutyrate were associated with VTDR. Comprehensive metabolic profiling in three large Asian cohorts with DR demonstrated alterations in serum/plasma and urinary metabolites mostly related to amino acids, lipoprotein subclasses, kidney function, and glycolysis.
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spelling pubmed-84674252021-09-27 Novel Serum and Urinary Metabolites Associated with Diabetic Retinopathy in Three Asian Cohorts Quek, Debra Q. Y. He, Feng Sultana, Rehena Banu, Riswana Chee, Miao Li Nusinovici, Simon Thakur, Sahil Qian, Chaoxu Cheng, Ching-Yu Wong, Tien Y. Sabanayagam, Charumathi Metabolites Article Diabetic retinopathy (DR) is a microvascular complication of diabetes mellitus, a metabolic disorder, but understanding of its pathophysiology remains incomplete. Meta-analysis of three population-based cross-sectional studies (2004–11) representing three major Asian ethnic groups (aged 40–80 years: Chinese, 592; Malays, 1052; Indians, 1320) was performed. A panel of 228 serum/plasma metabolites and 54 urinary metabolites were quantified using nuclear magnetic resonance (NMR) spectroscopy. Main outcomes were defined as any DR, moderate/above DR, and vision-threatening DR assessed from retinal photographs. The relationship between metabolites and DR outcomes was assessed using multivariate logistic regression models, and metabolites significant after Bonferroni correction were meta-analyzed. Among serum/plasma metabolites, lower levels of tyrosine and cholesterol esters to total lipids ratio in IDL and higher levels of creatinine were positively associated with all three outcomes of DR (all p < 0.005). Among urinary metabolites, lower levels of citrate, ethanolamine, formate, and hypoxanthine were positively associated with all three DR outcomes (all p < 0.005). Higher levels of serum/plasma 3-hydroxybutyrate and lower levels of urinary 3-hydroxyisobutyrate were associated with VTDR. Comprehensive metabolic profiling in three large Asian cohorts with DR demonstrated alterations in serum/plasma and urinary metabolites mostly related to amino acids, lipoprotein subclasses, kidney function, and glycolysis. MDPI 2021-09-09 /pmc/articles/PMC8467425/ /pubmed/34564429 http://dx.doi.org/10.3390/metabo11090614 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Quek, Debra Q. Y.
He, Feng
Sultana, Rehena
Banu, Riswana
Chee, Miao Li
Nusinovici, Simon
Thakur, Sahil
Qian, Chaoxu
Cheng, Ching-Yu
Wong, Tien Y.
Sabanayagam, Charumathi
Novel Serum and Urinary Metabolites Associated with Diabetic Retinopathy in Three Asian Cohorts
title Novel Serum and Urinary Metabolites Associated with Diabetic Retinopathy in Three Asian Cohorts
title_full Novel Serum and Urinary Metabolites Associated with Diabetic Retinopathy in Three Asian Cohorts
title_fullStr Novel Serum and Urinary Metabolites Associated with Diabetic Retinopathy in Three Asian Cohorts
title_full_unstemmed Novel Serum and Urinary Metabolites Associated with Diabetic Retinopathy in Three Asian Cohorts
title_short Novel Serum and Urinary Metabolites Associated with Diabetic Retinopathy in Three Asian Cohorts
title_sort novel serum and urinary metabolites associated with diabetic retinopathy in three asian cohorts
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467425/
https://www.ncbi.nlm.nih.gov/pubmed/34564429
http://dx.doi.org/10.3390/metabo11090614
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