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Novel Serum and Urinary Metabolites Associated with Diabetic Retinopathy in Three Asian Cohorts
Diabetic retinopathy (DR) is a microvascular complication of diabetes mellitus, a metabolic disorder, but understanding of its pathophysiology remains incomplete. Meta-analysis of three population-based cross-sectional studies (2004–11) representing three major Asian ethnic groups (aged 40–80 years:...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467425/ https://www.ncbi.nlm.nih.gov/pubmed/34564429 http://dx.doi.org/10.3390/metabo11090614 |
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author | Quek, Debra Q. Y. He, Feng Sultana, Rehena Banu, Riswana Chee, Miao Li Nusinovici, Simon Thakur, Sahil Qian, Chaoxu Cheng, Ching-Yu Wong, Tien Y. Sabanayagam, Charumathi |
author_facet | Quek, Debra Q. Y. He, Feng Sultana, Rehena Banu, Riswana Chee, Miao Li Nusinovici, Simon Thakur, Sahil Qian, Chaoxu Cheng, Ching-Yu Wong, Tien Y. Sabanayagam, Charumathi |
author_sort | Quek, Debra Q. Y. |
collection | PubMed |
description | Diabetic retinopathy (DR) is a microvascular complication of diabetes mellitus, a metabolic disorder, but understanding of its pathophysiology remains incomplete. Meta-analysis of three population-based cross-sectional studies (2004–11) representing three major Asian ethnic groups (aged 40–80 years: Chinese, 592; Malays, 1052; Indians, 1320) was performed. A panel of 228 serum/plasma metabolites and 54 urinary metabolites were quantified using nuclear magnetic resonance (NMR) spectroscopy. Main outcomes were defined as any DR, moderate/above DR, and vision-threatening DR assessed from retinal photographs. The relationship between metabolites and DR outcomes was assessed using multivariate logistic regression models, and metabolites significant after Bonferroni correction were meta-analyzed. Among serum/plasma metabolites, lower levels of tyrosine and cholesterol esters to total lipids ratio in IDL and higher levels of creatinine were positively associated with all three outcomes of DR (all p < 0.005). Among urinary metabolites, lower levels of citrate, ethanolamine, formate, and hypoxanthine were positively associated with all three DR outcomes (all p < 0.005). Higher levels of serum/plasma 3-hydroxybutyrate and lower levels of urinary 3-hydroxyisobutyrate were associated with VTDR. Comprehensive metabolic profiling in three large Asian cohorts with DR demonstrated alterations in serum/plasma and urinary metabolites mostly related to amino acids, lipoprotein subclasses, kidney function, and glycolysis. |
format | Online Article Text |
id | pubmed-8467425 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84674252021-09-27 Novel Serum and Urinary Metabolites Associated with Diabetic Retinopathy in Three Asian Cohorts Quek, Debra Q. Y. He, Feng Sultana, Rehena Banu, Riswana Chee, Miao Li Nusinovici, Simon Thakur, Sahil Qian, Chaoxu Cheng, Ching-Yu Wong, Tien Y. Sabanayagam, Charumathi Metabolites Article Diabetic retinopathy (DR) is a microvascular complication of diabetes mellitus, a metabolic disorder, but understanding of its pathophysiology remains incomplete. Meta-analysis of three population-based cross-sectional studies (2004–11) representing three major Asian ethnic groups (aged 40–80 years: Chinese, 592; Malays, 1052; Indians, 1320) was performed. A panel of 228 serum/plasma metabolites and 54 urinary metabolites were quantified using nuclear magnetic resonance (NMR) spectroscopy. Main outcomes were defined as any DR, moderate/above DR, and vision-threatening DR assessed from retinal photographs. The relationship between metabolites and DR outcomes was assessed using multivariate logistic regression models, and metabolites significant after Bonferroni correction were meta-analyzed. Among serum/plasma metabolites, lower levels of tyrosine and cholesterol esters to total lipids ratio in IDL and higher levels of creatinine were positively associated with all three outcomes of DR (all p < 0.005). Among urinary metabolites, lower levels of citrate, ethanolamine, formate, and hypoxanthine were positively associated with all three DR outcomes (all p < 0.005). Higher levels of serum/plasma 3-hydroxybutyrate and lower levels of urinary 3-hydroxyisobutyrate were associated with VTDR. Comprehensive metabolic profiling in three large Asian cohorts with DR demonstrated alterations in serum/plasma and urinary metabolites mostly related to amino acids, lipoprotein subclasses, kidney function, and glycolysis. MDPI 2021-09-09 /pmc/articles/PMC8467425/ /pubmed/34564429 http://dx.doi.org/10.3390/metabo11090614 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Quek, Debra Q. Y. He, Feng Sultana, Rehena Banu, Riswana Chee, Miao Li Nusinovici, Simon Thakur, Sahil Qian, Chaoxu Cheng, Ching-Yu Wong, Tien Y. Sabanayagam, Charumathi Novel Serum and Urinary Metabolites Associated with Diabetic Retinopathy in Three Asian Cohorts |
title | Novel Serum and Urinary Metabolites Associated with Diabetic Retinopathy in Three Asian Cohorts |
title_full | Novel Serum and Urinary Metabolites Associated with Diabetic Retinopathy in Three Asian Cohorts |
title_fullStr | Novel Serum and Urinary Metabolites Associated with Diabetic Retinopathy in Three Asian Cohorts |
title_full_unstemmed | Novel Serum and Urinary Metabolites Associated with Diabetic Retinopathy in Three Asian Cohorts |
title_short | Novel Serum and Urinary Metabolites Associated with Diabetic Retinopathy in Three Asian Cohorts |
title_sort | novel serum and urinary metabolites associated with diabetic retinopathy in three asian cohorts |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467425/ https://www.ncbi.nlm.nih.gov/pubmed/34564429 http://dx.doi.org/10.3390/metabo11090614 |
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