Cargando…

Attenuation of PITPNM1 Signaling Cascade Can Inhibit Breast Cancer Progression

Phosphatidylinositol transfer protein membrane-associated 1 (PITPNM1) contains a highly conserved phosphatidylinositol transfer domain which is involved in phosphoinositide trafficking and signaling transduction under physiological conditions. However, the functional role of PITPNM1 in cancer progre...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Zihao, Shi, Yu, Lin, Qun, Yang, Wenqian, Luo, Qing, Cen, Yinghuan, Li, Juanmei, Fang, Xiaolin, Jiang, Wen G., Gong, Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467484/
https://www.ncbi.nlm.nih.gov/pubmed/34572478
http://dx.doi.org/10.3390/biom11091265
_version_ 1784573409634549760
author Liu, Zihao
Shi, Yu
Lin, Qun
Yang, Wenqian
Luo, Qing
Cen, Yinghuan
Li, Juanmei
Fang, Xiaolin
Jiang, Wen G.
Gong, Chang
author_facet Liu, Zihao
Shi, Yu
Lin, Qun
Yang, Wenqian
Luo, Qing
Cen, Yinghuan
Li, Juanmei
Fang, Xiaolin
Jiang, Wen G.
Gong, Chang
author_sort Liu, Zihao
collection PubMed
description Phosphatidylinositol transfer protein membrane-associated 1 (PITPNM1) contains a highly conserved phosphatidylinositol transfer domain which is involved in phosphoinositide trafficking and signaling transduction under physiological conditions. However, the functional role of PITPNM1 in cancer progression remains unknown. Here, by integrating datasets of The Cancer Genome Atlas (TCGA) and Molecular Taxonomy of Breast Cancer (METABRIC), we found that the expression of PITPNM1 is much higher in breast cancer tissues than in normal breast tissues, and a high expression of PITPNM1 predicts a poor prognosis for breast cancer patients. Through gene set variation analysis (GSEA) and gene ontology (GO) analysis, we found PITPNM1 is mainly associated with carcinogenesis and cell-to-cell signaling ontology. Silencing of PITPNM1, in vitro, significantly abrogates proliferation and colony formation of breast cancer cells. Collectively, PITPNM1 is an important prognostic indicator and a potential therapeutic target for breast cancer.
format Online
Article
Text
id pubmed-8467484
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-84674842021-09-27 Attenuation of PITPNM1 Signaling Cascade Can Inhibit Breast Cancer Progression Liu, Zihao Shi, Yu Lin, Qun Yang, Wenqian Luo, Qing Cen, Yinghuan Li, Juanmei Fang, Xiaolin Jiang, Wen G. Gong, Chang Biomolecules Article Phosphatidylinositol transfer protein membrane-associated 1 (PITPNM1) contains a highly conserved phosphatidylinositol transfer domain which is involved in phosphoinositide trafficking and signaling transduction under physiological conditions. However, the functional role of PITPNM1 in cancer progression remains unknown. Here, by integrating datasets of The Cancer Genome Atlas (TCGA) and Molecular Taxonomy of Breast Cancer (METABRIC), we found that the expression of PITPNM1 is much higher in breast cancer tissues than in normal breast tissues, and a high expression of PITPNM1 predicts a poor prognosis for breast cancer patients. Through gene set variation analysis (GSEA) and gene ontology (GO) analysis, we found PITPNM1 is mainly associated with carcinogenesis and cell-to-cell signaling ontology. Silencing of PITPNM1, in vitro, significantly abrogates proliferation and colony formation of breast cancer cells. Collectively, PITPNM1 is an important prognostic indicator and a potential therapeutic target for breast cancer. MDPI 2021-08-25 /pmc/articles/PMC8467484/ /pubmed/34572478 http://dx.doi.org/10.3390/biom11091265 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liu, Zihao
Shi, Yu
Lin, Qun
Yang, Wenqian
Luo, Qing
Cen, Yinghuan
Li, Juanmei
Fang, Xiaolin
Jiang, Wen G.
Gong, Chang
Attenuation of PITPNM1 Signaling Cascade Can Inhibit Breast Cancer Progression
title Attenuation of PITPNM1 Signaling Cascade Can Inhibit Breast Cancer Progression
title_full Attenuation of PITPNM1 Signaling Cascade Can Inhibit Breast Cancer Progression
title_fullStr Attenuation of PITPNM1 Signaling Cascade Can Inhibit Breast Cancer Progression
title_full_unstemmed Attenuation of PITPNM1 Signaling Cascade Can Inhibit Breast Cancer Progression
title_short Attenuation of PITPNM1 Signaling Cascade Can Inhibit Breast Cancer Progression
title_sort attenuation of pitpnm1 signaling cascade can inhibit breast cancer progression
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467484/
https://www.ncbi.nlm.nih.gov/pubmed/34572478
http://dx.doi.org/10.3390/biom11091265
work_keys_str_mv AT liuzihao attenuationofpitpnm1signalingcascadecaninhibitbreastcancerprogression
AT shiyu attenuationofpitpnm1signalingcascadecaninhibitbreastcancerprogression
AT linqun attenuationofpitpnm1signalingcascadecaninhibitbreastcancerprogression
AT yangwenqian attenuationofpitpnm1signalingcascadecaninhibitbreastcancerprogression
AT luoqing attenuationofpitpnm1signalingcascadecaninhibitbreastcancerprogression
AT cenyinghuan attenuationofpitpnm1signalingcascadecaninhibitbreastcancerprogression
AT lijuanmei attenuationofpitpnm1signalingcascadecaninhibitbreastcancerprogression
AT fangxiaolin attenuationofpitpnm1signalingcascadecaninhibitbreastcancerprogression
AT jiangweng attenuationofpitpnm1signalingcascadecaninhibitbreastcancerprogression
AT gongchang attenuationofpitpnm1signalingcascadecaninhibitbreastcancerprogression