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Obesity and Thyroid Axis

Development of obesity is primarily the result of imbalance between energy intake and energy expenditure. Thyroid hormones influence energy expenditure by regulating cellular respiration and thermogenesis and by determining resting metabolic rate. Triiodothyronine influences lipid turnover in adipoc...

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Detalles Bibliográficos
Autores principales: Walczak, Krzysztof, Sieminska, Lucyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467528/
https://www.ncbi.nlm.nih.gov/pubmed/34574358
http://dx.doi.org/10.3390/ijerph18189434
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author Walczak, Krzysztof
Sieminska, Lucyna
author_facet Walczak, Krzysztof
Sieminska, Lucyna
author_sort Walczak, Krzysztof
collection PubMed
description Development of obesity is primarily the result of imbalance between energy intake and energy expenditure. Thyroid hormones influence energy expenditure by regulating cellular respiration and thermogenesis and by determining resting metabolic rate. Triiodothyronine influences lipid turnover in adipocytes and impacts appetite regulation through the central nervous system, mainly the hypothalamus. Thyroid-stimulating hormone may also influence thermogenesis, suppress appetite and regulate lipid storage through lipolysis and lipogenesis control. Subclinical hypothyroidism may induce changes in basal metabolic rate with subsequent increase in BMI, but obesity can also affect thyroid function via several mechanisms such as lipotoxicity and changes in adipokines and inflammatory cytokine secretion. The present study investigated the complex and mutual relationships between the thyroid axis and adiposity.
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spelling pubmed-84675282021-09-27 Obesity and Thyroid Axis Walczak, Krzysztof Sieminska, Lucyna Int J Environ Res Public Health Review Development of obesity is primarily the result of imbalance between energy intake and energy expenditure. Thyroid hormones influence energy expenditure by regulating cellular respiration and thermogenesis and by determining resting metabolic rate. Triiodothyronine influences lipid turnover in adipocytes and impacts appetite regulation through the central nervous system, mainly the hypothalamus. Thyroid-stimulating hormone may also influence thermogenesis, suppress appetite and regulate lipid storage through lipolysis and lipogenesis control. Subclinical hypothyroidism may induce changes in basal metabolic rate with subsequent increase in BMI, but obesity can also affect thyroid function via several mechanisms such as lipotoxicity and changes in adipokines and inflammatory cytokine secretion. The present study investigated the complex and mutual relationships between the thyroid axis and adiposity. MDPI 2021-09-07 /pmc/articles/PMC8467528/ /pubmed/34574358 http://dx.doi.org/10.3390/ijerph18189434 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Walczak, Krzysztof
Sieminska, Lucyna
Obesity and Thyroid Axis
title Obesity and Thyroid Axis
title_full Obesity and Thyroid Axis
title_fullStr Obesity and Thyroid Axis
title_full_unstemmed Obesity and Thyroid Axis
title_short Obesity and Thyroid Axis
title_sort obesity and thyroid axis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467528/
https://www.ncbi.nlm.nih.gov/pubmed/34574358
http://dx.doi.org/10.3390/ijerph18189434
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