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Obesity and Thyroid Axis
Development of obesity is primarily the result of imbalance between energy intake and energy expenditure. Thyroid hormones influence energy expenditure by regulating cellular respiration and thermogenesis and by determining resting metabolic rate. Triiodothyronine influences lipid turnover in adipoc...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467528/ https://www.ncbi.nlm.nih.gov/pubmed/34574358 http://dx.doi.org/10.3390/ijerph18189434 |
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author | Walczak, Krzysztof Sieminska, Lucyna |
author_facet | Walczak, Krzysztof Sieminska, Lucyna |
author_sort | Walczak, Krzysztof |
collection | PubMed |
description | Development of obesity is primarily the result of imbalance between energy intake and energy expenditure. Thyroid hormones influence energy expenditure by regulating cellular respiration and thermogenesis and by determining resting metabolic rate. Triiodothyronine influences lipid turnover in adipocytes and impacts appetite regulation through the central nervous system, mainly the hypothalamus. Thyroid-stimulating hormone may also influence thermogenesis, suppress appetite and regulate lipid storage through lipolysis and lipogenesis control. Subclinical hypothyroidism may induce changes in basal metabolic rate with subsequent increase in BMI, but obesity can also affect thyroid function via several mechanisms such as lipotoxicity and changes in adipokines and inflammatory cytokine secretion. The present study investigated the complex and mutual relationships between the thyroid axis and adiposity. |
format | Online Article Text |
id | pubmed-8467528 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84675282021-09-27 Obesity and Thyroid Axis Walczak, Krzysztof Sieminska, Lucyna Int J Environ Res Public Health Review Development of obesity is primarily the result of imbalance between energy intake and energy expenditure. Thyroid hormones influence energy expenditure by regulating cellular respiration and thermogenesis and by determining resting metabolic rate. Triiodothyronine influences lipid turnover in adipocytes and impacts appetite regulation through the central nervous system, mainly the hypothalamus. Thyroid-stimulating hormone may also influence thermogenesis, suppress appetite and regulate lipid storage through lipolysis and lipogenesis control. Subclinical hypothyroidism may induce changes in basal metabolic rate with subsequent increase in BMI, but obesity can also affect thyroid function via several mechanisms such as lipotoxicity and changes in adipokines and inflammatory cytokine secretion. The present study investigated the complex and mutual relationships between the thyroid axis and adiposity. MDPI 2021-09-07 /pmc/articles/PMC8467528/ /pubmed/34574358 http://dx.doi.org/10.3390/ijerph18189434 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Walczak, Krzysztof Sieminska, Lucyna Obesity and Thyroid Axis |
title | Obesity and Thyroid Axis |
title_full | Obesity and Thyroid Axis |
title_fullStr | Obesity and Thyroid Axis |
title_full_unstemmed | Obesity and Thyroid Axis |
title_short | Obesity and Thyroid Axis |
title_sort | obesity and thyroid axis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467528/ https://www.ncbi.nlm.nih.gov/pubmed/34574358 http://dx.doi.org/10.3390/ijerph18189434 |
work_keys_str_mv | AT walczakkrzysztof obesityandthyroidaxis AT sieminskalucyna obesityandthyroidaxis |