Cargando…

DYRK1A Kinase Inhibitors Promote β-Cell Survival and Insulin Homeostasis

The rising prevalence of diabetes is threatening global health. It is known not only for the occurrence of severe complications but also for the SARS-Cov-2 pandemic, which shows that it exacerbates susceptibility to infections. Current therapies focus on artificially maintaining insulin homeostasis,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Barzowska, Agata, Pucelik, Barbara, Pustelny, Katarzyna, Matsuda, Alex, Martyniak, Alicja, Stępniewski, Jacek, Maksymiuk, Anna, Dawidowski, Maciej, Rothweiler, Ulli, Dulak, Józef, Dubin, Grzegorz, Czarna, Anna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467532/ https://www.ncbi.nlm.nih.gov/pubmed/34571911 http://dx.doi.org/10.3390/cells10092263

Ejemplares similares

Binding mechanism and biological effects of flavone DYRK1A inhibitors for the design of new antidiabetics
por: Pustelny, Katarzyna, et al.
Publicado: (2023)

DYRK1A inhibitors leucettines and TGF-β inhibitor additively stimulate insulin production in beta cells, organoids, and isolated mouse islets
por: Pucelik, Barbara, et al.
Publicado: (2023)

Diabetic Kinome Inhibitors—A New Opportunity for β-Cells Restoration
por: Pucelik, Barbara, et al.
Publicado: (2021)

Silmitasertib (CX-4945), a Clinically Used CK2-Kinase Inhibitor with Additional Effects on GSK3β and DYRK1A Kinases: A Structural Perspective
por: Grygier, Przemyslaw, et al.
Publicado: (2023)

Compromised diabetic heart function is not affected by miR-378a upregulation upon hyperglycemia
por: Florczyk-Soluch, Urszula, et al.
Publicado: (2023)

Mechanism of MyD88S mediated signal termination
por: Pustelny, Katarzyna, et al.
Publicado: (2022)

Role of Heme-Oxygenase-1 in Biology of Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells
por: Jeż, Mateusz, et al.
Publicado: (2021)

Human-induced pluripotent stem cell-derived cardiomyocytes, 3D cardiac structures, and heart-on-a-chip as tools for drug research
por: Andrysiak, Kalina, et al.
Publicado: (2021)

Human iPSCs-Derived Endothelial Cells with Mutation in HNF1A as a Model of Maturity-Onset Diabetes of the Young
por: Kachamakova-Trojanowska, Neli, et al.
Publicado: (2019)

Photodynamic Inactivation of Bacteria with Porphyrin Derivatives: Effect of Charge, Lipophilicity, ROS Generation, and Cellular Uptake on Their Biological Activity In Vitro
por: Sułek, Adam, et al.
Publicado: (2020)

Novel DYRK1A Inhibitor Rescues Learning and Memory Deficits in a Mouse Model of Down Syndrome
por: Stensen, Wenche, et al.
Publicado: (2021)

Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes, in Contrast to Adipose Tissue-Derived Stromal Cells, Efficiently Improve Heart Function in Murine Model of Myocardial Infarction
por: Stępniewski, Jacek, et al.
Publicado: (2020)

Synthesis and Characterization of Size- and Charge-Tunable Silver Nanoparticles for Selective Anticancer and Antibacterial Treatment
por: Pucelik, Barbara, et al.
Publicado: (2022)

Pre-emptive hypoxia-regulated HO-1 gene therapy improves post-ischaemic limb perfusion and tissue regeneration in mice
por: Jazwa, Agnieszka, et al.
Publicado: (2013)

Synthetically Lethal Interactions of Heme Oxygenase-1 and Fumarate Hydratase Genes
por: Podkalicka, Paulina, et al.
Publicado: (2020)

Hypoxia as a Driving Force of Pluripotent Stem Cell Reprogramming and Differentiation to Endothelial Cells
por: Podkalicka, Paulina, et al.
Publicado: (2020)

Various roles of heme oxygenase-1 in response of bone marrow macrophages to RANKL and in the early stage of osteoclastogenesis
por: Florczyk-Soluch, Urszula, et al.
Publicado: (2018)

miR-378 affects metabolic disturbances in the mdx model of Duchenne muscular dystrophy
por: Podkalicka, Paulina, et al.
Publicado: (2022)

Imaging of Clear Cell Renal Carcinoma with Immune Checkpoint Targeting Aptamer-Based Probe
por: Malicki, Stanisław, et al.
Publicado: (2022)

Combined vascular endothelial growth factor-A and fibroblast growth factor 4 gene transfer improves wound healing in diabetic mice
por: Jazwa, Agnieszka, et al.
Publicado: (2010)

Age-Dependent Dysregulation of Muscle Vasculature and Blood Flow Recovery after Hindlimb Ischemia in the mdx Model of Duchenne Muscular Dystrophy
por: Podkalicka, Paulina, et al.
Publicado: (2021)

Cinnamic Acid Derivatives as Cardioprotective Agents against Oxidative and Structural Damage Induced by Doxorubicin
por: Koczurkiewicz-Adamczyk, Paulina, et al.
Publicado: (2021)

The role of oxidative stress in skeletal muscle injury and regeneration: focus on antioxidant enzymes
por: Kozakowska, Magdalena, et al.
Publicado: (2016)

Refolding of lid subdomain of SARS-CoV-2 nsp14 upon nsp10 interaction releases exonuclease activity
por: Czarna, Anna, et al.
Publicado: (2022)

Effect of heme oxygenase-1 on the differentiation of human myoblasts and the regeneration of murine skeletal muscles after acute and chronic injury
por: Głowniak-Kwitek, Urszula, et al.
Publicado: (2023)

Effect of Crossing C57BL/6 and FVB Mouse Strains on Basal Cytokine Expression
por: Szade, Agata, et al.
Publicado: (2015)

Atorvastatin and Conditioned Media from Atorvastatin-Treated Human Hematopoietic Stem/Progenitor-Derived Cells Show Proangiogenic Activity In Vitro but Not In Vivo
por: Nowak, Witold N., et al.
Publicado: (2019)

Aristolochic acid I and ochratoxin A differentially regulate VEGF expression in porcine kidney epithelial cells—The involvement of SP-1 and HIFs transcription factors
por: Stachurska, Anna, et al.
Publicado: (2011)

Two out of Three Musketeers Fight against Cancer: Synthesis, Physicochemical, and Biological Properties of Phosphino Cu(I), Ru(II), Ir(III) Complexes
por: Komarnicka, Urszula K., et al.
Publicado: (2022)

Mutational analysis of two residues in the DYRK homology box of the protein kinase DYRK1A
por: Widowati, Esti Wahyu, et al.
Publicado: (2018)

Properties of halogenated and sulfonated porphyrins relevant for the selection of photosensitizers in anticancer and antimicrobial therapies
por: Pucelik, Barbara, et al.
Publicado: (2017)

Correction: Properties of halogenated and sulfonated porphyrins relevant for the selection of photosensitizers in anticancer and antimicrobial therapies
por: Pucelik, Barbara, et al.
Publicado: (2018)

Safety and Feasibility of Lin- Cells Administration to ALS Patients: A Novel View on Humoral Factors and miRNA Profiles
por: Sobuś, Anna, et al.
Publicado: (2018)

The Role of miR-378a in Metabolism, Angiogenesis, and Muscle Biology
por: Krist, Bart, et al.
Publicado: (2015)

Variability in Cardiac miRNA-122 Level Determines Therapeutic Potential of miRNA-Regulated AAV Vectors
por: Kraszewska, Izabela, et al.
Publicado: (2020)

Myoblast-conditioned media improve regeneration and revascularization of ischemic muscles in diabetic mice
por: Kozakowska, Magdalena, et al.
Publicado: (2015)

DCAF7/WDR68 is required for normal levels of DYRK1A and DYRK1B
por: Yousefelahiyeh, Mina, et al.
Publicado: (2018)

Differential maturation and chaperone dependence of the paralogous protein kinases DYRK1A and DYRK1B
por: Papenfuss, Marco, et al.
Publicado: (2022)

Synthesis and biological investigations of 3β-aminotropane arylamide derivatives with atypical antipsychotic profile
por: Stefanowicz, Jacek, et al.
Publicado: (2018)

Liposomal Binuclear Ir(III)–Cu(II) Coordination Compounds with Phosphino-Fluoroquinolone Conjugates for Human Prostate Carcinoma Treatment
por: Komarnicka, Urszula K., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_tsqk1h8u6054g04olk8t8sqred