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Associations between Postprandial Gut Hormones and Markers of Bone Remodeling

Gut-derived hormones have been suggested to play a role in bone homeostasis following food intake, although the associations are highly complex and not fully understood. In a randomized, two-day cross-over study on 14 healthy individuals, we performed postprandial time-course studies to examine the...

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Autores principales: Jensen, Nina Wittorff, Clemmensen, Kim Katrine Bjerring, Jensen, Marie Møller, Pedersen, Hanne, Færch, Kristine, Diaz, Lars Jorge, Quist, Jonas Salling, Størling, Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467604/
https://www.ncbi.nlm.nih.gov/pubmed/34579074
http://dx.doi.org/10.3390/nu13093197
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author Jensen, Nina Wittorff
Clemmensen, Kim Katrine Bjerring
Jensen, Marie Møller
Pedersen, Hanne
Færch, Kristine
Diaz, Lars Jorge
Quist, Jonas Salling
Størling, Joachim
author_facet Jensen, Nina Wittorff
Clemmensen, Kim Katrine Bjerring
Jensen, Marie Møller
Pedersen, Hanne
Færch, Kristine
Diaz, Lars Jorge
Quist, Jonas Salling
Størling, Joachim
author_sort Jensen, Nina Wittorff
collection PubMed
description Gut-derived hormones have been suggested to play a role in bone homeostasis following food intake, although the associations are highly complex and not fully understood. In a randomized, two-day cross-over study on 14 healthy individuals, we performed postprandial time-course studies to examine the associations of the bone remodeling markers carboxyl-terminal collagen type I crosslinks (CTX) and procollagen type 1 N-terminal propeptide (P1NP) with the gut hormones glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide 1 (GLP-1), and peptide YY (PYY) using two different meal types—a standardized mixed meal (498 kcal) or a granola bar (260 kcal). Plasma concentrations of total GIP, total GLP-1, total PYY, CTX, and P1NP were measured up to 240 min after meal intake, and the incremental area under the curve (iAUC) for each marker was calculated. The iAUC of CTX and P1NP were used to assess associations with the iAUC of GIP, GLP-1, and PYY in linear mixed effect models adjusted for meal type. CTX was positively associated with GIP and GLP-1, and it was inversely associated with PYY (all p < 0.001). No associations of P1NP with GIP or GLP-1 and PYY were found. In conclusion, the postprandial responses of the gut hormones GIP, GLP-1, and PYY are associated with the bone resorption marker CTX, supporting a link between gut hormones and bone homeostasis following food intake.
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spelling pubmed-84676042021-09-27 Associations between Postprandial Gut Hormones and Markers of Bone Remodeling Jensen, Nina Wittorff Clemmensen, Kim Katrine Bjerring Jensen, Marie Møller Pedersen, Hanne Færch, Kristine Diaz, Lars Jorge Quist, Jonas Salling Størling, Joachim Nutrients Article Gut-derived hormones have been suggested to play a role in bone homeostasis following food intake, although the associations are highly complex and not fully understood. In a randomized, two-day cross-over study on 14 healthy individuals, we performed postprandial time-course studies to examine the associations of the bone remodeling markers carboxyl-terminal collagen type I crosslinks (CTX) and procollagen type 1 N-terminal propeptide (P1NP) with the gut hormones glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide 1 (GLP-1), and peptide YY (PYY) using two different meal types—a standardized mixed meal (498 kcal) or a granola bar (260 kcal). Plasma concentrations of total GIP, total GLP-1, total PYY, CTX, and P1NP were measured up to 240 min after meal intake, and the incremental area under the curve (iAUC) for each marker was calculated. The iAUC of CTX and P1NP were used to assess associations with the iAUC of GIP, GLP-1, and PYY in linear mixed effect models adjusted for meal type. CTX was positively associated with GIP and GLP-1, and it was inversely associated with PYY (all p < 0.001). No associations of P1NP with GIP or GLP-1 and PYY were found. In conclusion, the postprandial responses of the gut hormones GIP, GLP-1, and PYY are associated with the bone resorption marker CTX, supporting a link between gut hormones and bone homeostasis following food intake. MDPI 2021-09-14 /pmc/articles/PMC8467604/ /pubmed/34579074 http://dx.doi.org/10.3390/nu13093197 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jensen, Nina Wittorff
Clemmensen, Kim Katrine Bjerring
Jensen, Marie Møller
Pedersen, Hanne
Færch, Kristine
Diaz, Lars Jorge
Quist, Jonas Salling
Størling, Joachim
Associations between Postprandial Gut Hormones and Markers of Bone Remodeling
title Associations between Postprandial Gut Hormones and Markers of Bone Remodeling
title_full Associations between Postprandial Gut Hormones and Markers of Bone Remodeling
title_fullStr Associations between Postprandial Gut Hormones and Markers of Bone Remodeling
title_full_unstemmed Associations between Postprandial Gut Hormones and Markers of Bone Remodeling
title_short Associations between Postprandial Gut Hormones and Markers of Bone Remodeling
title_sort associations between postprandial gut hormones and markers of bone remodeling
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467604/
https://www.ncbi.nlm.nih.gov/pubmed/34579074
http://dx.doi.org/10.3390/nu13093197
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