Cargando…
Associations between Postprandial Gut Hormones and Markers of Bone Remodeling
Gut-derived hormones have been suggested to play a role in bone homeostasis following food intake, although the associations are highly complex and not fully understood. In a randomized, two-day cross-over study on 14 healthy individuals, we performed postprandial time-course studies to examine the...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467604/ https://www.ncbi.nlm.nih.gov/pubmed/34579074 http://dx.doi.org/10.3390/nu13093197 |
_version_ | 1784573440220463104 |
---|---|
author | Jensen, Nina Wittorff Clemmensen, Kim Katrine Bjerring Jensen, Marie Møller Pedersen, Hanne Færch, Kristine Diaz, Lars Jorge Quist, Jonas Salling Størling, Joachim |
author_facet | Jensen, Nina Wittorff Clemmensen, Kim Katrine Bjerring Jensen, Marie Møller Pedersen, Hanne Færch, Kristine Diaz, Lars Jorge Quist, Jonas Salling Størling, Joachim |
author_sort | Jensen, Nina Wittorff |
collection | PubMed |
description | Gut-derived hormones have been suggested to play a role in bone homeostasis following food intake, although the associations are highly complex and not fully understood. In a randomized, two-day cross-over study on 14 healthy individuals, we performed postprandial time-course studies to examine the associations of the bone remodeling markers carboxyl-terminal collagen type I crosslinks (CTX) and procollagen type 1 N-terminal propeptide (P1NP) with the gut hormones glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide 1 (GLP-1), and peptide YY (PYY) using two different meal types—a standardized mixed meal (498 kcal) or a granola bar (260 kcal). Plasma concentrations of total GIP, total GLP-1, total PYY, CTX, and P1NP were measured up to 240 min after meal intake, and the incremental area under the curve (iAUC) for each marker was calculated. The iAUC of CTX and P1NP were used to assess associations with the iAUC of GIP, GLP-1, and PYY in linear mixed effect models adjusted for meal type. CTX was positively associated with GIP and GLP-1, and it was inversely associated with PYY (all p < 0.001). No associations of P1NP with GIP or GLP-1 and PYY were found. In conclusion, the postprandial responses of the gut hormones GIP, GLP-1, and PYY are associated with the bone resorption marker CTX, supporting a link between gut hormones and bone homeostasis following food intake. |
format | Online Article Text |
id | pubmed-8467604 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84676042021-09-27 Associations between Postprandial Gut Hormones and Markers of Bone Remodeling Jensen, Nina Wittorff Clemmensen, Kim Katrine Bjerring Jensen, Marie Møller Pedersen, Hanne Færch, Kristine Diaz, Lars Jorge Quist, Jonas Salling Størling, Joachim Nutrients Article Gut-derived hormones have been suggested to play a role in bone homeostasis following food intake, although the associations are highly complex and not fully understood. In a randomized, two-day cross-over study on 14 healthy individuals, we performed postprandial time-course studies to examine the associations of the bone remodeling markers carboxyl-terminal collagen type I crosslinks (CTX) and procollagen type 1 N-terminal propeptide (P1NP) with the gut hormones glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide 1 (GLP-1), and peptide YY (PYY) using two different meal types—a standardized mixed meal (498 kcal) or a granola bar (260 kcal). Plasma concentrations of total GIP, total GLP-1, total PYY, CTX, and P1NP were measured up to 240 min after meal intake, and the incremental area under the curve (iAUC) for each marker was calculated. The iAUC of CTX and P1NP were used to assess associations with the iAUC of GIP, GLP-1, and PYY in linear mixed effect models adjusted for meal type. CTX was positively associated with GIP and GLP-1, and it was inversely associated with PYY (all p < 0.001). No associations of P1NP with GIP or GLP-1 and PYY were found. In conclusion, the postprandial responses of the gut hormones GIP, GLP-1, and PYY are associated with the bone resorption marker CTX, supporting a link between gut hormones and bone homeostasis following food intake. MDPI 2021-09-14 /pmc/articles/PMC8467604/ /pubmed/34579074 http://dx.doi.org/10.3390/nu13093197 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Jensen, Nina Wittorff Clemmensen, Kim Katrine Bjerring Jensen, Marie Møller Pedersen, Hanne Færch, Kristine Diaz, Lars Jorge Quist, Jonas Salling Størling, Joachim Associations between Postprandial Gut Hormones and Markers of Bone Remodeling |
title | Associations between Postprandial Gut Hormones and Markers of Bone Remodeling |
title_full | Associations between Postprandial Gut Hormones and Markers of Bone Remodeling |
title_fullStr | Associations between Postprandial Gut Hormones and Markers of Bone Remodeling |
title_full_unstemmed | Associations between Postprandial Gut Hormones and Markers of Bone Remodeling |
title_short | Associations between Postprandial Gut Hormones and Markers of Bone Remodeling |
title_sort | associations between postprandial gut hormones and markers of bone remodeling |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467604/ https://www.ncbi.nlm.nih.gov/pubmed/34579074 http://dx.doi.org/10.3390/nu13093197 |
work_keys_str_mv | AT jensenninawittorff associationsbetweenpostprandialguthormonesandmarkersofboneremodeling AT clemmensenkimkatrinebjerring associationsbetweenpostprandialguthormonesandmarkersofboneremodeling AT jensenmariemøller associationsbetweenpostprandialguthormonesandmarkersofboneremodeling AT pedersenhanne associationsbetweenpostprandialguthormonesandmarkersofboneremodeling AT færchkristine associationsbetweenpostprandialguthormonesandmarkersofboneremodeling AT diazlarsjorge associationsbetweenpostprandialguthormonesandmarkersofboneremodeling AT quistjonassalling associationsbetweenpostprandialguthormonesandmarkersofboneremodeling AT størlingjoachim associationsbetweenpostprandialguthormonesandmarkersofboneremodeling |