Cargando…

Autophagy, Mesenchymal Stem Cell Differentiation, and Secretion

Mesenchymal stem cells (MSC) are multipotent cells capable to differentiate into adipogenic, osteogenic, and chondrogenic directions, possessing immunomodulatory activity and a capability to stimulate angiogenesis. A scope of these features and capabilities makes MSC a significant factor of tissue h...

Descripción completa

Detalles Bibliográficos
Autores principales: Menshikov, Mikhail, Zubkova, Ekaterina, Stafeev, Iuri, Parfyonova, Yelena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467641/
https://www.ncbi.nlm.nih.gov/pubmed/34572364
http://dx.doi.org/10.3390/biomedicines9091178
_version_ 1784573450016260096
author Menshikov, Mikhail
Zubkova, Ekaterina
Stafeev, Iuri
Parfyonova, Yelena
author_facet Menshikov, Mikhail
Zubkova, Ekaterina
Stafeev, Iuri
Parfyonova, Yelena
author_sort Menshikov, Mikhail
collection PubMed
description Mesenchymal stem cells (MSC) are multipotent cells capable to differentiate into adipogenic, osteogenic, and chondrogenic directions, possessing immunomodulatory activity and a capability to stimulate angiogenesis. A scope of these features and capabilities makes MSC a significant factor of tissue homeostasis and repair. Among factors determining the fate of MSC, a prominent place belongs to autophagy, which is activated under different conditions including cell starvation, inflammation, oxidative stress, and some others. In addition to supporting cell homeostasis by elimination of protein aggregates, and non-functional and damaged proteins, autophagy is a necessary factor of change in cell phenotype on the process of cell differentiation. In present review, some mechanisms providing participation of autophagy in cell differentiation are discussed
format Online
Article
Text
id pubmed-8467641
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-84676412021-09-27 Autophagy, Mesenchymal Stem Cell Differentiation, and Secretion Menshikov, Mikhail Zubkova, Ekaterina Stafeev, Iuri Parfyonova, Yelena Biomedicines Review Mesenchymal stem cells (MSC) are multipotent cells capable to differentiate into adipogenic, osteogenic, and chondrogenic directions, possessing immunomodulatory activity and a capability to stimulate angiogenesis. A scope of these features and capabilities makes MSC a significant factor of tissue homeostasis and repair. Among factors determining the fate of MSC, a prominent place belongs to autophagy, which is activated under different conditions including cell starvation, inflammation, oxidative stress, and some others. In addition to supporting cell homeostasis by elimination of protein aggregates, and non-functional and damaged proteins, autophagy is a necessary factor of change in cell phenotype on the process of cell differentiation. In present review, some mechanisms providing participation of autophagy in cell differentiation are discussed MDPI 2021-09-07 /pmc/articles/PMC8467641/ /pubmed/34572364 http://dx.doi.org/10.3390/biomedicines9091178 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Menshikov, Mikhail
Zubkova, Ekaterina
Stafeev, Iuri
Parfyonova, Yelena
Autophagy, Mesenchymal Stem Cell Differentiation, and Secretion
title Autophagy, Mesenchymal Stem Cell Differentiation, and Secretion
title_full Autophagy, Mesenchymal Stem Cell Differentiation, and Secretion
title_fullStr Autophagy, Mesenchymal Stem Cell Differentiation, and Secretion
title_full_unstemmed Autophagy, Mesenchymal Stem Cell Differentiation, and Secretion
title_short Autophagy, Mesenchymal Stem Cell Differentiation, and Secretion
title_sort autophagy, mesenchymal stem cell differentiation, and secretion
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467641/
https://www.ncbi.nlm.nih.gov/pubmed/34572364
http://dx.doi.org/10.3390/biomedicines9091178
work_keys_str_mv AT menshikovmikhail autophagymesenchymalstemcelldifferentiationandsecretion
AT zubkovaekaterina autophagymesenchymalstemcelldifferentiationandsecretion
AT stafeeviuri autophagymesenchymalstemcelldifferentiationandsecretion
AT parfyonovayelena autophagymesenchymalstemcelldifferentiationandsecretion