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Autophagy, Mesenchymal Stem Cell Differentiation, and Secretion
Mesenchymal stem cells (MSC) are multipotent cells capable to differentiate into adipogenic, osteogenic, and chondrogenic directions, possessing immunomodulatory activity and a capability to stimulate angiogenesis. A scope of these features and capabilities makes MSC a significant factor of tissue h...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467641/ https://www.ncbi.nlm.nih.gov/pubmed/34572364 http://dx.doi.org/10.3390/biomedicines9091178 |
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author | Menshikov, Mikhail Zubkova, Ekaterina Stafeev, Iuri Parfyonova, Yelena |
author_facet | Menshikov, Mikhail Zubkova, Ekaterina Stafeev, Iuri Parfyonova, Yelena |
author_sort | Menshikov, Mikhail |
collection | PubMed |
description | Mesenchymal stem cells (MSC) are multipotent cells capable to differentiate into adipogenic, osteogenic, and chondrogenic directions, possessing immunomodulatory activity and a capability to stimulate angiogenesis. A scope of these features and capabilities makes MSC a significant factor of tissue homeostasis and repair. Among factors determining the fate of MSC, a prominent place belongs to autophagy, which is activated under different conditions including cell starvation, inflammation, oxidative stress, and some others. In addition to supporting cell homeostasis by elimination of protein aggregates, and non-functional and damaged proteins, autophagy is a necessary factor of change in cell phenotype on the process of cell differentiation. In present review, some mechanisms providing participation of autophagy in cell differentiation are discussed |
format | Online Article Text |
id | pubmed-8467641 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84676412021-09-27 Autophagy, Mesenchymal Stem Cell Differentiation, and Secretion Menshikov, Mikhail Zubkova, Ekaterina Stafeev, Iuri Parfyonova, Yelena Biomedicines Review Mesenchymal stem cells (MSC) are multipotent cells capable to differentiate into adipogenic, osteogenic, and chondrogenic directions, possessing immunomodulatory activity and a capability to stimulate angiogenesis. A scope of these features and capabilities makes MSC a significant factor of tissue homeostasis and repair. Among factors determining the fate of MSC, a prominent place belongs to autophagy, which is activated under different conditions including cell starvation, inflammation, oxidative stress, and some others. In addition to supporting cell homeostasis by elimination of protein aggregates, and non-functional and damaged proteins, autophagy is a necessary factor of change in cell phenotype on the process of cell differentiation. In present review, some mechanisms providing participation of autophagy in cell differentiation are discussed MDPI 2021-09-07 /pmc/articles/PMC8467641/ /pubmed/34572364 http://dx.doi.org/10.3390/biomedicines9091178 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Menshikov, Mikhail Zubkova, Ekaterina Stafeev, Iuri Parfyonova, Yelena Autophagy, Mesenchymal Stem Cell Differentiation, and Secretion |
title | Autophagy, Mesenchymal Stem Cell Differentiation, and Secretion |
title_full | Autophagy, Mesenchymal Stem Cell Differentiation, and Secretion |
title_fullStr | Autophagy, Mesenchymal Stem Cell Differentiation, and Secretion |
title_full_unstemmed | Autophagy, Mesenchymal Stem Cell Differentiation, and Secretion |
title_short | Autophagy, Mesenchymal Stem Cell Differentiation, and Secretion |
title_sort | autophagy, mesenchymal stem cell differentiation, and secretion |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467641/ https://www.ncbi.nlm.nih.gov/pubmed/34572364 http://dx.doi.org/10.3390/biomedicines9091178 |
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