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Supplemented Low-Protein Diet May Delay the Need for Preemptive Kidney Transplantation: A Nationwide Population-Based Cohort Study

Background: Although several studies suggest the benefit of a low-protein diet supplemented with amino acids and keto acids (sLPD) in delaying the initiation of hemodialysis, evidence on whether these nutritional approaches could delay the timing of preemptive transplantation is lacking. Methods: Re...

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Autores principales: Yen, Chieh-Li, Fan, Pei-Chun, Kuo, George, Chen, Chao-Yu, Cheng, Ya-Lien, Hsu, Hsiang-Hao, Tian, Ya-Chun, Chatrenet, Antoine, Piccoli, Giorgina Barbara, Chang, Chih-Hsiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467708/
https://www.ncbi.nlm.nih.gov/pubmed/34578879
http://dx.doi.org/10.3390/nu13093002
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author Yen, Chieh-Li
Fan, Pei-Chun
Kuo, George
Chen, Chao-Yu
Cheng, Ya-Lien
Hsu, Hsiang-Hao
Tian, Ya-Chun
Chatrenet, Antoine
Piccoli, Giorgina Barbara
Chang, Chih-Hsiang
author_facet Yen, Chieh-Li
Fan, Pei-Chun
Kuo, George
Chen, Chao-Yu
Cheng, Ya-Lien
Hsu, Hsiang-Hao
Tian, Ya-Chun
Chatrenet, Antoine
Piccoli, Giorgina Barbara
Chang, Chih-Hsiang
author_sort Yen, Chieh-Li
collection PubMed
description Background: Although several studies suggest the benefit of a low-protein diet supplemented with amino acids and keto acids (sLPD) in delaying the initiation of hemodialysis, evidence on whether these nutritional approaches could delay the timing of preemptive transplantation is lacking. Methods: Retrospective nationwide cohort study, from Taiwan’s National Health Insurance Research Database. Patients having undergone a first preemptive kidney transplantation between 2001 and 2017 were identified and divided into two groups according to the presence of sLPD treatment or not. The primary outcome was the time between the diagnosis of advanced CKD and transplantation. Secondary outcomes were post-transplantation adverse events. Results: A total of 245 patients who received their first preemptive kidney transplantation were identified from the nationwide database; 63 of them had been on an sLPD prior to transplantation (sLPD group). The duration between the day of advanced CKD diagnosis and the day of transplantation was significantly longer in the sLPD group compared with the non-sLPD group (median duration: 345 vs. 220 days, p = 0.001). The risk of post-transplantation adverse events did not differ between the two groups. Conclusions: Within the limits of its observational, retrospective design, this is the first study to suggest that nutritional management with sLPDs can safely delay the timing of preemptive kidney transplantation.
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spelling pubmed-84677082021-09-27 Supplemented Low-Protein Diet May Delay the Need for Preemptive Kidney Transplantation: A Nationwide Population-Based Cohort Study Yen, Chieh-Li Fan, Pei-Chun Kuo, George Chen, Chao-Yu Cheng, Ya-Lien Hsu, Hsiang-Hao Tian, Ya-Chun Chatrenet, Antoine Piccoli, Giorgina Barbara Chang, Chih-Hsiang Nutrients Article Background: Although several studies suggest the benefit of a low-protein diet supplemented with amino acids and keto acids (sLPD) in delaying the initiation of hemodialysis, evidence on whether these nutritional approaches could delay the timing of preemptive transplantation is lacking. Methods: Retrospective nationwide cohort study, from Taiwan’s National Health Insurance Research Database. Patients having undergone a first preemptive kidney transplantation between 2001 and 2017 were identified and divided into two groups according to the presence of sLPD treatment or not. The primary outcome was the time between the diagnosis of advanced CKD and transplantation. Secondary outcomes were post-transplantation adverse events. Results: A total of 245 patients who received their first preemptive kidney transplantation were identified from the nationwide database; 63 of them had been on an sLPD prior to transplantation (sLPD group). The duration between the day of advanced CKD diagnosis and the day of transplantation was significantly longer in the sLPD group compared with the non-sLPD group (median duration: 345 vs. 220 days, p = 0.001). The risk of post-transplantation adverse events did not differ between the two groups. Conclusions: Within the limits of its observational, retrospective design, this is the first study to suggest that nutritional management with sLPDs can safely delay the timing of preemptive kidney transplantation. MDPI 2021-08-28 /pmc/articles/PMC8467708/ /pubmed/34578879 http://dx.doi.org/10.3390/nu13093002 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yen, Chieh-Li
Fan, Pei-Chun
Kuo, George
Chen, Chao-Yu
Cheng, Ya-Lien
Hsu, Hsiang-Hao
Tian, Ya-Chun
Chatrenet, Antoine
Piccoli, Giorgina Barbara
Chang, Chih-Hsiang
Supplemented Low-Protein Diet May Delay the Need for Preemptive Kidney Transplantation: A Nationwide Population-Based Cohort Study
title Supplemented Low-Protein Diet May Delay the Need for Preemptive Kidney Transplantation: A Nationwide Population-Based Cohort Study
title_full Supplemented Low-Protein Diet May Delay the Need for Preemptive Kidney Transplantation: A Nationwide Population-Based Cohort Study
title_fullStr Supplemented Low-Protein Diet May Delay the Need for Preemptive Kidney Transplantation: A Nationwide Population-Based Cohort Study
title_full_unstemmed Supplemented Low-Protein Diet May Delay the Need for Preemptive Kidney Transplantation: A Nationwide Population-Based Cohort Study
title_short Supplemented Low-Protein Diet May Delay the Need for Preemptive Kidney Transplantation: A Nationwide Population-Based Cohort Study
title_sort supplemented low-protein diet may delay the need for preemptive kidney transplantation: a nationwide population-based cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467708/
https://www.ncbi.nlm.nih.gov/pubmed/34578879
http://dx.doi.org/10.3390/nu13093002
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