Oxygenated Cembrene Diterpenes from Sarcophyton convolutum: Cytotoxic Sarcoconvolutum A–E

The soft coral genus Sarcophyton contains the enzymatic machinery to synthesize a multitude of cembrene-type diterpenes. Herein, highly oxygenated cembrenoids, sarcoconvolutum A–E (1–5) were purified and characterized from an ethyl acetate extract of the red sea soft coral, Sarcophyton convolutum. C...

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Autores principales: Mohamed, Tarik A., Elshamy, Abdelsamed I., Abdel-Tawab, Asmaa M., AbdelMohsen, Mona M., Ohta, Shinji, Pare, Paul W., Hegazy, Mohamed-Elamir F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467724/
https://www.ncbi.nlm.nih.gov/pubmed/34564181
http://dx.doi.org/10.3390/md19090519
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author Mohamed, Tarik A.
Elshamy, Abdelsamed I.
Abdel-Tawab, Asmaa M.
AbdelMohsen, Mona M.
Ohta, Shinji
Pare, Paul W.
Hegazy, Mohamed-Elamir F.
author_facet Mohamed, Tarik A.
Elshamy, Abdelsamed I.
Abdel-Tawab, Asmaa M.
AbdelMohsen, Mona M.
Ohta, Shinji
Pare, Paul W.
Hegazy, Mohamed-Elamir F.
author_sort Mohamed, Tarik A.
collection PubMed
description The soft coral genus Sarcophyton contains the enzymatic machinery to synthesize a multitude of cembrene-type diterpenes. Herein, highly oxygenated cembrenoids, sarcoconvolutum A–E (1–5) were purified and characterized from an ethyl acetate extract of the red sea soft coral, Sarcophyton convolutum. Compounds were assemblies according to spectroscopic methods including FTIR, 1D- and 2D-NMR as well as HRMS. Metabolite cytotoxicity was tested against lung adenocarcinoma, cervical cancer, and oral-cavity carcinoma (A549, HeLa and HSC-2, respectively). The most cytotoxic compound, (4) was observed to be active against cell lines A549 and HSC-2 with IC(50) values of 49.70 and 53.17 μM, respectively.
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spelling pubmed-84677242021-09-27 Oxygenated Cembrene Diterpenes from Sarcophyton convolutum: Cytotoxic Sarcoconvolutum A–E Mohamed, Tarik A. Elshamy, Abdelsamed I. Abdel-Tawab, Asmaa M. AbdelMohsen, Mona M. Ohta, Shinji Pare, Paul W. Hegazy, Mohamed-Elamir F. Mar Drugs Article The soft coral genus Sarcophyton contains the enzymatic machinery to synthesize a multitude of cembrene-type diterpenes. Herein, highly oxygenated cembrenoids, sarcoconvolutum A–E (1–5) were purified and characterized from an ethyl acetate extract of the red sea soft coral, Sarcophyton convolutum. Compounds were assemblies according to spectroscopic methods including FTIR, 1D- and 2D-NMR as well as HRMS. Metabolite cytotoxicity was tested against lung adenocarcinoma, cervical cancer, and oral-cavity carcinoma (A549, HeLa and HSC-2, respectively). The most cytotoxic compound, (4) was observed to be active against cell lines A549 and HSC-2 with IC(50) values of 49.70 and 53.17 μM, respectively. MDPI 2021-09-13 /pmc/articles/PMC8467724/ /pubmed/34564181 http://dx.doi.org/10.3390/md19090519 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mohamed, Tarik A.
Elshamy, Abdelsamed I.
Abdel-Tawab, Asmaa M.
AbdelMohsen, Mona M.
Ohta, Shinji
Pare, Paul W.
Hegazy, Mohamed-Elamir F.
Oxygenated Cembrene Diterpenes from Sarcophyton convolutum: Cytotoxic Sarcoconvolutum A–E
title Oxygenated Cembrene Diterpenes from Sarcophyton convolutum: Cytotoxic Sarcoconvolutum A–E
title_full Oxygenated Cembrene Diterpenes from Sarcophyton convolutum: Cytotoxic Sarcoconvolutum A–E
title_fullStr Oxygenated Cembrene Diterpenes from Sarcophyton convolutum: Cytotoxic Sarcoconvolutum A–E
title_full_unstemmed Oxygenated Cembrene Diterpenes from Sarcophyton convolutum: Cytotoxic Sarcoconvolutum A–E
title_short Oxygenated Cembrene Diterpenes from Sarcophyton convolutum: Cytotoxic Sarcoconvolutum A–E
title_sort oxygenated cembrene diterpenes from sarcophyton convolutum: cytotoxic sarcoconvolutum a–e
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467724/
https://www.ncbi.nlm.nih.gov/pubmed/34564181
http://dx.doi.org/10.3390/md19090519
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