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Peptide Inhibitors of Vascular Endothelial Growth Factor A: Current Situation and Perspectives

Vascular endothelial growth factors (VEGFs) are the family of extracellular signaling proteins involved in the processes of angiogenesis. VEGFA overexpression and altered regulation of VEGFA signaling pathways lead to pathological angiogenesis, which contributes to the progression of various disease...

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Detalles Bibliográficos
Autores principales: Guryanov, Ivan, Tennikova, Tatiana, Urtti, Arto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467741/
https://www.ncbi.nlm.nih.gov/pubmed/34575413
http://dx.doi.org/10.3390/pharmaceutics13091337
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author Guryanov, Ivan
Tennikova, Tatiana
Urtti, Arto
author_facet Guryanov, Ivan
Tennikova, Tatiana
Urtti, Arto
author_sort Guryanov, Ivan
collection PubMed
description Vascular endothelial growth factors (VEGFs) are the family of extracellular signaling proteins involved in the processes of angiogenesis. VEGFA overexpression and altered regulation of VEGFA signaling pathways lead to pathological angiogenesis, which contributes to the progression of various diseases, such as age-related macular degeneration and cancer. Monoclonal antibodies and decoy receptors have been extensively used in the anti-angiogenic therapies for the neutralization of VEGFA. However, multiple side effects, solubility and aggregation issues, and the involvement of compensatory VEGFA-independent pro-angiogenic mechanisms limit the use of the existing VEGFA inhibitors. Short chemically synthesized VEGFA binding peptides are a promising alternative to these full-length proteins. In this review, we summarize anti-VEGFA peptides identified so far and discuss the molecular basis of their inhibitory activity to highlight their pharmacological potential as anti-angiogenic drugs.
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spelling pubmed-84677412021-09-27 Peptide Inhibitors of Vascular Endothelial Growth Factor A: Current Situation and Perspectives Guryanov, Ivan Tennikova, Tatiana Urtti, Arto Pharmaceutics Review Vascular endothelial growth factors (VEGFs) are the family of extracellular signaling proteins involved in the processes of angiogenesis. VEGFA overexpression and altered regulation of VEGFA signaling pathways lead to pathological angiogenesis, which contributes to the progression of various diseases, such as age-related macular degeneration and cancer. Monoclonal antibodies and decoy receptors have been extensively used in the anti-angiogenic therapies for the neutralization of VEGFA. However, multiple side effects, solubility and aggregation issues, and the involvement of compensatory VEGFA-independent pro-angiogenic mechanisms limit the use of the existing VEGFA inhibitors. Short chemically synthesized VEGFA binding peptides are a promising alternative to these full-length proteins. In this review, we summarize anti-VEGFA peptides identified so far and discuss the molecular basis of their inhibitory activity to highlight their pharmacological potential as anti-angiogenic drugs. MDPI 2021-08-26 /pmc/articles/PMC8467741/ /pubmed/34575413 http://dx.doi.org/10.3390/pharmaceutics13091337 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Guryanov, Ivan
Tennikova, Tatiana
Urtti, Arto
Peptide Inhibitors of Vascular Endothelial Growth Factor A: Current Situation and Perspectives
title Peptide Inhibitors of Vascular Endothelial Growth Factor A: Current Situation and Perspectives
title_full Peptide Inhibitors of Vascular Endothelial Growth Factor A: Current Situation and Perspectives
title_fullStr Peptide Inhibitors of Vascular Endothelial Growth Factor A: Current Situation and Perspectives
title_full_unstemmed Peptide Inhibitors of Vascular Endothelial Growth Factor A: Current Situation and Perspectives
title_short Peptide Inhibitors of Vascular Endothelial Growth Factor A: Current Situation and Perspectives
title_sort peptide inhibitors of vascular endothelial growth factor a: current situation and perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467741/
https://www.ncbi.nlm.nih.gov/pubmed/34575413
http://dx.doi.org/10.3390/pharmaceutics13091337
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