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Peptide Inhibitors of Vascular Endothelial Growth Factor A: Current Situation and Perspectives
Vascular endothelial growth factors (VEGFs) are the family of extracellular signaling proteins involved in the processes of angiogenesis. VEGFA overexpression and altered regulation of VEGFA signaling pathways lead to pathological angiogenesis, which contributes to the progression of various disease...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467741/ https://www.ncbi.nlm.nih.gov/pubmed/34575413 http://dx.doi.org/10.3390/pharmaceutics13091337 |
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author | Guryanov, Ivan Tennikova, Tatiana Urtti, Arto |
author_facet | Guryanov, Ivan Tennikova, Tatiana Urtti, Arto |
author_sort | Guryanov, Ivan |
collection | PubMed |
description | Vascular endothelial growth factors (VEGFs) are the family of extracellular signaling proteins involved in the processes of angiogenesis. VEGFA overexpression and altered regulation of VEGFA signaling pathways lead to pathological angiogenesis, which contributes to the progression of various diseases, such as age-related macular degeneration and cancer. Monoclonal antibodies and decoy receptors have been extensively used in the anti-angiogenic therapies for the neutralization of VEGFA. However, multiple side effects, solubility and aggregation issues, and the involvement of compensatory VEGFA-independent pro-angiogenic mechanisms limit the use of the existing VEGFA inhibitors. Short chemically synthesized VEGFA binding peptides are a promising alternative to these full-length proteins. In this review, we summarize anti-VEGFA peptides identified so far and discuss the molecular basis of their inhibitory activity to highlight their pharmacological potential as anti-angiogenic drugs. |
format | Online Article Text |
id | pubmed-8467741 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84677412021-09-27 Peptide Inhibitors of Vascular Endothelial Growth Factor A: Current Situation and Perspectives Guryanov, Ivan Tennikova, Tatiana Urtti, Arto Pharmaceutics Review Vascular endothelial growth factors (VEGFs) are the family of extracellular signaling proteins involved in the processes of angiogenesis. VEGFA overexpression and altered regulation of VEGFA signaling pathways lead to pathological angiogenesis, which contributes to the progression of various diseases, such as age-related macular degeneration and cancer. Monoclonal antibodies and decoy receptors have been extensively used in the anti-angiogenic therapies for the neutralization of VEGFA. However, multiple side effects, solubility and aggregation issues, and the involvement of compensatory VEGFA-independent pro-angiogenic mechanisms limit the use of the existing VEGFA inhibitors. Short chemically synthesized VEGFA binding peptides are a promising alternative to these full-length proteins. In this review, we summarize anti-VEGFA peptides identified so far and discuss the molecular basis of their inhibitory activity to highlight their pharmacological potential as anti-angiogenic drugs. MDPI 2021-08-26 /pmc/articles/PMC8467741/ /pubmed/34575413 http://dx.doi.org/10.3390/pharmaceutics13091337 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Guryanov, Ivan Tennikova, Tatiana Urtti, Arto Peptide Inhibitors of Vascular Endothelial Growth Factor A: Current Situation and Perspectives |
title | Peptide Inhibitors of Vascular Endothelial Growth Factor A: Current Situation and Perspectives |
title_full | Peptide Inhibitors of Vascular Endothelial Growth Factor A: Current Situation and Perspectives |
title_fullStr | Peptide Inhibitors of Vascular Endothelial Growth Factor A: Current Situation and Perspectives |
title_full_unstemmed | Peptide Inhibitors of Vascular Endothelial Growth Factor A: Current Situation and Perspectives |
title_short | Peptide Inhibitors of Vascular Endothelial Growth Factor A: Current Situation and Perspectives |
title_sort | peptide inhibitors of vascular endothelial growth factor a: current situation and perspectives |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467741/ https://www.ncbi.nlm.nih.gov/pubmed/34575413 http://dx.doi.org/10.3390/pharmaceutics13091337 |
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