Specific Engineered G Protein Coupling to Histamine Receptors Revealed from Cellular Assay Experiments and Accelerated Molecular Dynamics Simulations

G protein-coupled receptors (GPCRs) are targets of extracellular stimuli and hence occupy a key position in drug discovery. By specific and not yet fully elucidated coupling profiles with α subunits of distinct G protein families, they regulate cellular responses. The histamine H(2) and H(4) recepto...

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Detalles Bibliográficos
Autores principales: Höring, Carina, Conrad, Marcus, Söldner, Christian A., Wang, Jinan, Sticht, Heinrich, Strasser, Andrea, Miao, Yinglong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467750/
https://www.ncbi.nlm.nih.gov/pubmed/34576210
http://dx.doi.org/10.3390/ijms221810047

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