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Specific Engineered G Protein Coupling to Histamine Receptors Revealed from Cellular Assay Experiments and Accelerated Molecular Dynamics Simulations
G protein-coupled receptors (GPCRs) are targets of extracellular stimuli and hence occupy a key position in drug discovery. By specific and not yet fully elucidated coupling profiles with α subunits of distinct G protein families, they regulate cellular responses. The histamine H(2) and H(4) recepto...
Autores principales: | Höring, Carina, Conrad, Marcus, Söldner, Christian A., Wang, Jinan, Sticht, Heinrich, Strasser, Andrea, Miao, Yinglong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467750/ https://www.ncbi.nlm.nih.gov/pubmed/34576210 http://dx.doi.org/10.3390/ijms221810047 |
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