Cargando…
The Histaminergic System in Neuropsychiatric Disorders
Histamine does not only modulate the immune response and inflammation, but also acts as a neurotransmitter in the mammalian brain. The histaminergic system plays a significant role in the maintenance of wakefulness, appetite regulation, cognition and arousal, which are severely affected in neuropsyc...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467868/ https://www.ncbi.nlm.nih.gov/pubmed/34572558 http://dx.doi.org/10.3390/biom11091345 |
_version_ | 1784573511797309440 |
---|---|
author | Cheng, Li Liu, Jiaying Chen, Zhong |
author_facet | Cheng, Li Liu, Jiaying Chen, Zhong |
author_sort | Cheng, Li |
collection | PubMed |
description | Histamine does not only modulate the immune response and inflammation, but also acts as a neurotransmitter in the mammalian brain. The histaminergic system plays a significant role in the maintenance of wakefulness, appetite regulation, cognition and arousal, which are severely affected in neuropsychiatric disorders. In this review, we first briefly describe the distribution of histaminergic neurons, histamine receptors and their intracellular pathways. Next, we comprehensively summarize recent experimental and clinical findings on the precise role of histaminergic system in neuropsychiatric disorders, including cell-type role and its circuit bases in narcolepsy, schizophrenia, Alzheimer’s disease, Tourette’s syndrome and Parkinson’s disease. Finally, we provide some perspectives on future research to illustrate the curative role of the histaminergic system in neuropsychiatric disorders. |
format | Online Article Text |
id | pubmed-8467868 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84678682021-09-27 The Histaminergic System in Neuropsychiatric Disorders Cheng, Li Liu, Jiaying Chen, Zhong Biomolecules Review Histamine does not only modulate the immune response and inflammation, but also acts as a neurotransmitter in the mammalian brain. The histaminergic system plays a significant role in the maintenance of wakefulness, appetite regulation, cognition and arousal, which are severely affected in neuropsychiatric disorders. In this review, we first briefly describe the distribution of histaminergic neurons, histamine receptors and their intracellular pathways. Next, we comprehensively summarize recent experimental and clinical findings on the precise role of histaminergic system in neuropsychiatric disorders, including cell-type role and its circuit bases in narcolepsy, schizophrenia, Alzheimer’s disease, Tourette’s syndrome and Parkinson’s disease. Finally, we provide some perspectives on future research to illustrate the curative role of the histaminergic system in neuropsychiatric disorders. MDPI 2021-09-11 /pmc/articles/PMC8467868/ /pubmed/34572558 http://dx.doi.org/10.3390/biom11091345 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Cheng, Li Liu, Jiaying Chen, Zhong The Histaminergic System in Neuropsychiatric Disorders |
title | The Histaminergic System in Neuropsychiatric Disorders |
title_full | The Histaminergic System in Neuropsychiatric Disorders |
title_fullStr | The Histaminergic System in Neuropsychiatric Disorders |
title_full_unstemmed | The Histaminergic System in Neuropsychiatric Disorders |
title_short | The Histaminergic System in Neuropsychiatric Disorders |
title_sort | histaminergic system in neuropsychiatric disorders |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467868/ https://www.ncbi.nlm.nih.gov/pubmed/34572558 http://dx.doi.org/10.3390/biom11091345 |
work_keys_str_mv | AT chengli thehistaminergicsysteminneuropsychiatricdisorders AT liujiaying thehistaminergicsysteminneuropsychiatricdisorders AT chenzhong thehistaminergicsysteminneuropsychiatricdisorders AT chengli histaminergicsysteminneuropsychiatricdisorders AT liujiaying histaminergicsysteminneuropsychiatricdisorders AT chenzhong histaminergicsysteminneuropsychiatricdisorders |