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The Histaminergic System in Neuropsychiatric Disorders

Histamine does not only modulate the immune response and inflammation, but also acts as a neurotransmitter in the mammalian brain. The histaminergic system plays a significant role in the maintenance of wakefulness, appetite regulation, cognition and arousal, which are severely affected in neuropsyc...

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Detalles Bibliográficos
Autores principales: Cheng, Li, Liu, Jiaying, Chen, Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467868/
https://www.ncbi.nlm.nih.gov/pubmed/34572558
http://dx.doi.org/10.3390/biom11091345
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author Cheng, Li
Liu, Jiaying
Chen, Zhong
author_facet Cheng, Li
Liu, Jiaying
Chen, Zhong
author_sort Cheng, Li
collection PubMed
description Histamine does not only modulate the immune response and inflammation, but also acts as a neurotransmitter in the mammalian brain. The histaminergic system plays a significant role in the maintenance of wakefulness, appetite regulation, cognition and arousal, which are severely affected in neuropsychiatric disorders. In this review, we first briefly describe the distribution of histaminergic neurons, histamine receptors and their intracellular pathways. Next, we comprehensively summarize recent experimental and clinical findings on the precise role of histaminergic system in neuropsychiatric disorders, including cell-type role and its circuit bases in narcolepsy, schizophrenia, Alzheimer’s disease, Tourette’s syndrome and Parkinson’s disease. Finally, we provide some perspectives on future research to illustrate the curative role of the histaminergic system in neuropsychiatric disorders.
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spelling pubmed-84678682021-09-27 The Histaminergic System in Neuropsychiatric Disorders Cheng, Li Liu, Jiaying Chen, Zhong Biomolecules Review Histamine does not only modulate the immune response and inflammation, but also acts as a neurotransmitter in the mammalian brain. The histaminergic system plays a significant role in the maintenance of wakefulness, appetite regulation, cognition and arousal, which are severely affected in neuropsychiatric disorders. In this review, we first briefly describe the distribution of histaminergic neurons, histamine receptors and their intracellular pathways. Next, we comprehensively summarize recent experimental and clinical findings on the precise role of histaminergic system in neuropsychiatric disorders, including cell-type role and its circuit bases in narcolepsy, schizophrenia, Alzheimer’s disease, Tourette’s syndrome and Parkinson’s disease. Finally, we provide some perspectives on future research to illustrate the curative role of the histaminergic system in neuropsychiatric disorders. MDPI 2021-09-11 /pmc/articles/PMC8467868/ /pubmed/34572558 http://dx.doi.org/10.3390/biom11091345 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cheng, Li
Liu, Jiaying
Chen, Zhong
The Histaminergic System in Neuropsychiatric Disorders
title The Histaminergic System in Neuropsychiatric Disorders
title_full The Histaminergic System in Neuropsychiatric Disorders
title_fullStr The Histaminergic System in Neuropsychiatric Disorders
title_full_unstemmed The Histaminergic System in Neuropsychiatric Disorders
title_short The Histaminergic System in Neuropsychiatric Disorders
title_sort histaminergic system in neuropsychiatric disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467868/
https://www.ncbi.nlm.nih.gov/pubmed/34572558
http://dx.doi.org/10.3390/biom11091345
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