Cargando…

Evaluation of the Influence of a Hydrogel Containing AMPD on the Stability of Tetracycline Hydrochloride

Tetracyclines, as beneficial antimicrobial factors in both local and systemic therapy, are characterized by high instability. The aim of the study was the development of the influence of hydrogel formulation on the tetracycline hydrochloride (TC) level under varying storage conditions. The HPLC, XPR...

Descripción completa

Detalles Bibliográficos
Autores principales: Kostrzębska, Agnieszka, Złocińska, Adrianna, Musiał, Witold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468035/
https://www.ncbi.nlm.nih.gov/pubmed/34575457
http://dx.doi.org/10.3390/pharmaceutics13091381
_version_ 1784573557184921600
author Kostrzębska, Agnieszka
Złocińska, Adrianna
Musiał, Witold
author_facet Kostrzębska, Agnieszka
Złocińska, Adrianna
Musiał, Witold
author_sort Kostrzębska, Agnieszka
collection PubMed
description Tetracyclines, as beneficial antimicrobial factors in both local and systemic therapy, are characterized by high instability. The aim of the study was the development of the influence of hydrogel formulation on the tetracycline hydrochloride (TC) level under varying storage conditions. The HPLC, XPRD as well as SEM and macroscopic observations were involved in the study. The TC concentration decreased within ca. two months from 9.37 µg/mL to 4.41 µg/mL in the case of the photoprotected TC solution stored at 23 °C, whereas the decrease in storage temperature did not improve the final level of TC. In the presence of AMPD, the TC level in aqueous solution decreased drastically to ca. 1 µg/mL. Application of a polyacrylic acid derivative enabled conservation of the TC level through the ca. two months. Thus, the use of alcoholamine in the preparation of the TC hydrogel may result in the development of a therapeutic product with a dual action against acne, including antimicrobial activity and saponification of free fatty acids deposited in the follicles.
format Online
Article
Text
id pubmed-8468035
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-84680352021-09-27 Evaluation of the Influence of a Hydrogel Containing AMPD on the Stability of Tetracycline Hydrochloride Kostrzębska, Agnieszka Złocińska, Adrianna Musiał, Witold Pharmaceutics Article Tetracyclines, as beneficial antimicrobial factors in both local and systemic therapy, are characterized by high instability. The aim of the study was the development of the influence of hydrogel formulation on the tetracycline hydrochloride (TC) level under varying storage conditions. The HPLC, XPRD as well as SEM and macroscopic observations were involved in the study. The TC concentration decreased within ca. two months from 9.37 µg/mL to 4.41 µg/mL in the case of the photoprotected TC solution stored at 23 °C, whereas the decrease in storage temperature did not improve the final level of TC. In the presence of AMPD, the TC level in aqueous solution decreased drastically to ca. 1 µg/mL. Application of a polyacrylic acid derivative enabled conservation of the TC level through the ca. two months. Thus, the use of alcoholamine in the preparation of the TC hydrogel may result in the development of a therapeutic product with a dual action against acne, including antimicrobial activity and saponification of free fatty acids deposited in the follicles. MDPI 2021-09-01 /pmc/articles/PMC8468035/ /pubmed/34575457 http://dx.doi.org/10.3390/pharmaceutics13091381 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kostrzębska, Agnieszka
Złocińska, Adrianna
Musiał, Witold
Evaluation of the Influence of a Hydrogel Containing AMPD on the Stability of Tetracycline Hydrochloride
title Evaluation of the Influence of a Hydrogel Containing AMPD on the Stability of Tetracycline Hydrochloride
title_full Evaluation of the Influence of a Hydrogel Containing AMPD on the Stability of Tetracycline Hydrochloride
title_fullStr Evaluation of the Influence of a Hydrogel Containing AMPD on the Stability of Tetracycline Hydrochloride
title_full_unstemmed Evaluation of the Influence of a Hydrogel Containing AMPD on the Stability of Tetracycline Hydrochloride
title_short Evaluation of the Influence of a Hydrogel Containing AMPD on the Stability of Tetracycline Hydrochloride
title_sort evaluation of the influence of a hydrogel containing ampd on the stability of tetracycline hydrochloride
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468035/
https://www.ncbi.nlm.nih.gov/pubmed/34575457
http://dx.doi.org/10.3390/pharmaceutics13091381
work_keys_str_mv AT kostrzebskaagnieszka evaluationoftheinfluenceofahydrogelcontainingampdonthestabilityoftetracyclinehydrochloride
AT złocinskaadrianna evaluationoftheinfluenceofahydrogelcontainingampdonthestabilityoftetracyclinehydrochloride
AT musiałwitold evaluationoftheinfluenceofahydrogelcontainingampdonthestabilityoftetracyclinehydrochloride