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Evaluation of the Influence of a Hydrogel Containing AMPD on the Stability of Tetracycline Hydrochloride
Tetracyclines, as beneficial antimicrobial factors in both local and systemic therapy, are characterized by high instability. The aim of the study was the development of the influence of hydrogel formulation on the tetracycline hydrochloride (TC) level under varying storage conditions. The HPLC, XPR...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468035/ https://www.ncbi.nlm.nih.gov/pubmed/34575457 http://dx.doi.org/10.3390/pharmaceutics13091381 |
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author | Kostrzębska, Agnieszka Złocińska, Adrianna Musiał, Witold |
author_facet | Kostrzębska, Agnieszka Złocińska, Adrianna Musiał, Witold |
author_sort | Kostrzębska, Agnieszka |
collection | PubMed |
description | Tetracyclines, as beneficial antimicrobial factors in both local and systemic therapy, are characterized by high instability. The aim of the study was the development of the influence of hydrogel formulation on the tetracycline hydrochloride (TC) level under varying storage conditions. The HPLC, XPRD as well as SEM and macroscopic observations were involved in the study. The TC concentration decreased within ca. two months from 9.37 µg/mL to 4.41 µg/mL in the case of the photoprotected TC solution stored at 23 °C, whereas the decrease in storage temperature did not improve the final level of TC. In the presence of AMPD, the TC level in aqueous solution decreased drastically to ca. 1 µg/mL. Application of a polyacrylic acid derivative enabled conservation of the TC level through the ca. two months. Thus, the use of alcoholamine in the preparation of the TC hydrogel may result in the development of a therapeutic product with a dual action against acne, including antimicrobial activity and saponification of free fatty acids deposited in the follicles. |
format | Online Article Text |
id | pubmed-8468035 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84680352021-09-27 Evaluation of the Influence of a Hydrogel Containing AMPD on the Stability of Tetracycline Hydrochloride Kostrzębska, Agnieszka Złocińska, Adrianna Musiał, Witold Pharmaceutics Article Tetracyclines, as beneficial antimicrobial factors in both local and systemic therapy, are characterized by high instability. The aim of the study was the development of the influence of hydrogel formulation on the tetracycline hydrochloride (TC) level under varying storage conditions. The HPLC, XPRD as well as SEM and macroscopic observations were involved in the study. The TC concentration decreased within ca. two months from 9.37 µg/mL to 4.41 µg/mL in the case of the photoprotected TC solution stored at 23 °C, whereas the decrease in storage temperature did not improve the final level of TC. In the presence of AMPD, the TC level in aqueous solution decreased drastically to ca. 1 µg/mL. Application of a polyacrylic acid derivative enabled conservation of the TC level through the ca. two months. Thus, the use of alcoholamine in the preparation of the TC hydrogel may result in the development of a therapeutic product with a dual action against acne, including antimicrobial activity and saponification of free fatty acids deposited in the follicles. MDPI 2021-09-01 /pmc/articles/PMC8468035/ /pubmed/34575457 http://dx.doi.org/10.3390/pharmaceutics13091381 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kostrzębska, Agnieszka Złocińska, Adrianna Musiał, Witold Evaluation of the Influence of a Hydrogel Containing AMPD on the Stability of Tetracycline Hydrochloride |
title | Evaluation of the Influence of a Hydrogel Containing AMPD on the Stability of Tetracycline Hydrochloride |
title_full | Evaluation of the Influence of a Hydrogel Containing AMPD on the Stability of Tetracycline Hydrochloride |
title_fullStr | Evaluation of the Influence of a Hydrogel Containing AMPD on the Stability of Tetracycline Hydrochloride |
title_full_unstemmed | Evaluation of the Influence of a Hydrogel Containing AMPD on the Stability of Tetracycline Hydrochloride |
title_short | Evaluation of the Influence of a Hydrogel Containing AMPD on the Stability of Tetracycline Hydrochloride |
title_sort | evaluation of the influence of a hydrogel containing ampd on the stability of tetracycline hydrochloride |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468035/ https://www.ncbi.nlm.nih.gov/pubmed/34575457 http://dx.doi.org/10.3390/pharmaceutics13091381 |
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