Cargando…

Microarray Analysis Revealed Inflammatory Transcriptomic Changes after LSL60101 Treatment in 5XFAD Mice Model

I2-IR have been found dysregulated in patients with neurodegenerative diseases, such as Alzheimer’s disease (AD), in which the importance of neuroinflammation in the establishment and maintenance of cognitive decline is well-documented. To research the implication of I2-IR in neuroinflammatory pathw...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vasilopoulou, Foteini, Escolano, Carmen, Pallàs, Mercè, Griñán-Ferré, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468036/ https://www.ncbi.nlm.nih.gov/pubmed/34573297 http://dx.doi.org/10.3390/genes12091315

Ejemplares similares

Amelioration of BPSD-Like Phenotype and Cognitive Decline in SAMP8 Mice Model Accompanied by Molecular Changes after Treatment with I(2)-Imidazoline Receptor Ligand MCR5
por: Vasilopoulou, Foteini, et al.
Publicado: (2020)

Epigenetic mechanisms underlying cognitive impairment and Alzheimer disease hallmarks in 5XFAD mice
por: Griñán-Ferré, Christian, et al.
Publicado: (2016)

NMDA receptor antagonists reduce amyloid-β deposition by modulating calpain-1 signaling and autophagy, rescuing cognitive impairment in 5XFAD mice
por: Companys-Alemany, Júlia, et al.
Publicado: (2022)

Environmental Enrichment Improves Cognitive Deficits, AD Hallmarks and Epigenetic Alterations Presented in 5xFAD Mouse Model
por: Griñán-Ferré, Christian, et al.
Publicado: (2018)

Cognitive Decline and BPSD Are Concomitant with Autophagic and Synaptic Deficits Associated with G9a Alterations in Aged SAMP8 Mice
por: Vasilopoulou, Foteini, et al.
Publicado: (2022)

Chronic Mild Stress Modified Epigenetic Mechanisms Leading to Accelerated Senescence and Impaired Cognitive Performance in Mice
por: Puigoriol-Illamola, Dolors, et al.
Publicado: (2020)

The Contribution of Epigenetic Inheritance Processes on Age-Related Cognitive Decline and Alzheimer’s Disease
por: Bellver-Sanchis, Aina, et al.
Publicado: (2021)

Glial cell reactivity and oxidative stress prevention in Alzheimer’s disease mice model by an optimized NMDA receptor antagonist
por: Companys-Alemany, Júlia, et al.
Publicado: (2022)

Adenosine and Metabotropic Glutamate Receptors Are Present in Blood Serum and Exosomes from SAMP8 Mice: Modulation by Aging and Resveratrol
por: Sánchez-Melgar, Alejandro, et al.
Publicado: (2020)

Correction: Izquierdo et al. Resveratrol Supplementation Attenuates Cognitive and Molecular Alterations under Maternal High-Fat Diet Intake: Epigenetic Inheritance over Generations. Int. J. Mol. Sci. 2021, 22, 1453
por: Izquierdo, Vanesa, et al.
Publicado: (2021)

Resveratrol Supplementation Attenuates Cognitive and Molecular Alterations under Maternal High-Fat Diet Intake: Epigenetic Inheritance over Generations
por: Izquierdo, Vanesa, et al.
Publicado: (2021)

Synergistic Neuroprotective Effects of a Natural Product Mixture against AD Hallmarks and Cognitive Decline in Caenorhabditis elegans and an SAMP8 Mice Model
por: Griñán-Ferré, Christian, et al.
Publicado: (2021)

Maternal Resveratrol Supplementation Prevents Cognitive Decline in Senescent Mice Offspring
por: Izquierdo, Vanesa, et al.
Publicado: (2019)

Soluble Epoxide Hydrolase Inhibition to Face Neuroinflammation in Parkinson’s Disease: A New Therapeutic Strategy
por: Pallàs, Mercè, et al.
Publicado: (2020)

A Combined Chronic Low-Dose Soluble Epoxide Hydrolase and Acetylcholinesterase Pharmacological Inhibition Promotes Memory Reinstatement in Alzheimer’s Disease Mice Models
por: Jarne-Ferrer, Júlia, et al.
Publicado: (2022)

Neuroprotective Effects of Resveratrol by Modifying Cholesterol Metabolism and Aβ Processing in SAMP8 Mice
por: Sánchez-Melgar, Alejandro, et al.
Publicado: (2022)

Dietary Spray-Dried Porcine Plasma Reduces Neuropathological Alzheimer’s Disease Hallmarks in SAMP8 Mice
por: Rosell-Cardona, Cristina, et al.
Publicado: (2021)

Understanding Epigenetics in the Neurodegeneration of Alzheimer’s Disease: SAMP8 Mouse Model
por: Griñán-Ferré, Christian, et al.
Publicado: (2018)

Reply to Nifli, A.-P. Comment on “Rosell-Cardona et al. Dietary Spray-Dried Porcine Plasma Reduces Neuropathological Alzheimer’s Disease Hallmarks in SAMP8 Mice. Nutrients 2021, 13, 2369”
por: Rosell-Cardona, Cristina, et al.
Publicado: (2021)

The Role of the miR-17-92 Cluster in Autophagy and Atherosclerosis Supports Its Link to Lysosomal Storage Diseases
por: Ortuño-Sahagún, Daniel, et al.
Publicado: (2022)

Insights into the Pharmacokinetics and In Vitro Cell-Based Studies of the Imidazoline I(2) Receptor Ligand B06
por: Bagán, Andrea, et al.
Publicado: (2022)

LSL-Kras(G12D); LSL-Trp53(R172H/+); Ink4(flox/+); Ptf1/p48-Cre mice are an applicable model for locally invasive and metastatic pancreatic cancer
por: Ma, Lixiang, et al.
Publicado: (2017)

Schubert. Symphony No.9, Grosse C-Dur Great C Major. Günter Wand, Kölner Rundfunk-Sinfonie-Orchester. GD 60101/

Pharmacological inhibition of G9a/GLP restores cognition and reduces oxidative stress, neuroinflammation and β-Amyloid plaques in an early-onset Alzheimer’s disease mouse model
por: Griñán-Ferré, Christian, et al.
Publicado: (2019)

The Neuroprotective Effects of Spray-Dried Porcine Plasma Supplementation Involve the Microbiota−Gut−Brain Axis
por: Rosell-Cardona, Cristina, et al.
Publicado: (2022)

Inhibition of 11β-HSD1 Ameliorates Cognition and Molecular Detrimental Changes after Chronic Mild Stress in SAMP8 Mice
por: Puigoriol-Illamola, Dolors, et al.
Publicado: (2021)

A Novel NMDA Receptor Antagonist Protects against Cognitive Decline Presented by Senescent Mice
por: Companys-Alemany, Júlia, et al.
Publicado: (2020)

Dry age-related macular degeneration like pathology in aged 5XFAD mice: Ultrastructure and microarray analysis
por: Park, Sung Wook, et al.
Publicado: (2017)

Chronic liquid fructose supplementation does not cause liver tumorigenesis but elicits clear sex differences in the metabolic response in Sprague–Dawley rats
por: Roglans, Nuria, et al.
Publicado: (2021)

Neuroprotective Epigenetic Changes Induced by Maternal Treatment with an Inhibitor of Soluble Epoxide Hydrolase Prevents Early Alzheimer′s Disease Neurodegeneration
por: Bartra, Clara, et al.
Publicado: (2022)

Preclinical Evaluation of an Imidazole-Linked Heterocycle for Alzheimer’s Disease
por: Bagán, Andrea, et al.
Publicado: (2023)

Temporal Integrative Analysis of mRNA and microRNAs Expression Profiles and Epigenetic Alterations in Female SAMP8, a Model of Age-Related Cognitive Decline
por: Cosín-Tomás, Marta, et al.
Publicado: (2018)

Global DNA Methylation and Hydroxymethylation Levels in PBMCs Are Altered in RRMS Patients Treated with IFN-β and GA—A Preliminary Study
por: Reyes-Mata, María Paulina, et al.
Publicado: (2023)

Structure‐Based Virtual Screening and in vitro and in vivo Analyses Revealed Potent Methyltransferase G9a Inhibitors as Prospective Anti‐Alzheimer's Agents
por: Bellver‐Sanchis, Aina, et al.
Publicado: (2022)

Microarray analysis reveals an inflammatory transcriptomic signature in peripheral blood for sciatica
por: Wang, Yi, et al.
Publicado: (2021)

Development of thymic tumor in [LSL:Kras(G12D); Pdx1-CRE] mice, an adverse effect associated with accelerated pancreatic carcinogenesis
por: Liot, Sophie, et al.
Publicado: (2021)

Microarray microRNA profiling of urinary exosomes in a 5XFAD mouse model of Alzheimer’s disease
por: Song, Zhiqi, et al.
Publicado: (2021)

AAV‐mediated expression of secreted and transmembrane αKlotho isoforms rescues relevant aging hallmarks in senescent SAMP8 mice
por: Roig‐Soriano, J., et al.
Publicado: (2022)

Environmental Enrichment Modified Epigenetic Mechanisms in SAMP8 Mouse Hippocampus by Reducing Oxidative Stress and Inflammaging and Achieving Neuroprotection
por: Griñan-Ferré, Christian, et al.
Publicado: (2016)

Inhibition of Soluble Epoxide Hydrolase Ameliorates Phenotype and Cognitive Abilities in a Murine Model of Niemann Pick Type C Disease
por: Griñán-Ferré, Christian, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_pud0i8oqe4iom34n1qa7rqagqr