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Polymer-Derived Biosilicate(®)-like Glass-Ceramics: Engineering of Formulations and Additive Manufacturing of Three-Dimensional Scaffolds

Silicone resins, filled with phosphates and other oxide fillers, yield upon firing in air at 1100 °C, a product resembling Biosilicate(®) glass-ceramics, one of the most promising systems for tissue engineering applications. The process requires no preliminary synthesis of parent glass, and the poly...

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Autores principales: Dogrul, Fulden, Ożóg, Paulina, Michálek, Martin, Elsayed, Hamada, Galusek, Dušan, Liverani, Liliana, Boccaccini, Aldo R., Bernardo, Enrico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468046/
https://www.ncbi.nlm.nih.gov/pubmed/34576394
http://dx.doi.org/10.3390/ma14185170
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author Dogrul, Fulden
Ożóg, Paulina
Michálek, Martin
Elsayed, Hamada
Galusek, Dušan
Liverani, Liliana
Boccaccini, Aldo R.
Bernardo, Enrico
author_facet Dogrul, Fulden
Ożóg, Paulina
Michálek, Martin
Elsayed, Hamada
Galusek, Dušan
Liverani, Liliana
Boccaccini, Aldo R.
Bernardo, Enrico
author_sort Dogrul, Fulden
collection PubMed
description Silicone resins, filled with phosphates and other oxide fillers, yield upon firing in air at 1100 °C, a product resembling Biosilicate(®) glass-ceramics, one of the most promising systems for tissue engineering applications. The process requires no preliminary synthesis of parent glass, and the polymer route enables the application of direct ink writing (DIW) of silicone-based mixtures, for the manufacturing of reticulated scaffolds at room temperature. The thermal treatment is later applied for the conversion into ceramic scaffolds. The present paper further elucidates the flexibility of the approach. Changes in the reference silicone and firing atmosphere (from air to nitrogen) were studied to obtain functional composite biomaterials featuring a carbon phase embedded in a Biosilicate(®)-like matrix. The microstructure was further modified either through a controlled gas release at a low temperature, or by the revision of the adopted additive manufacturing technology (from DIW to digital light processing).
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spelling pubmed-84680462021-09-27 Polymer-Derived Biosilicate(®)-like Glass-Ceramics: Engineering of Formulations and Additive Manufacturing of Three-Dimensional Scaffolds Dogrul, Fulden Ożóg, Paulina Michálek, Martin Elsayed, Hamada Galusek, Dušan Liverani, Liliana Boccaccini, Aldo R. Bernardo, Enrico Materials (Basel) Article Silicone resins, filled with phosphates and other oxide fillers, yield upon firing in air at 1100 °C, a product resembling Biosilicate(®) glass-ceramics, one of the most promising systems for tissue engineering applications. The process requires no preliminary synthesis of parent glass, and the polymer route enables the application of direct ink writing (DIW) of silicone-based mixtures, for the manufacturing of reticulated scaffolds at room temperature. The thermal treatment is later applied for the conversion into ceramic scaffolds. The present paper further elucidates the flexibility of the approach. Changes in the reference silicone and firing atmosphere (from air to nitrogen) were studied to obtain functional composite biomaterials featuring a carbon phase embedded in a Biosilicate(®)-like matrix. The microstructure was further modified either through a controlled gas release at a low temperature, or by the revision of the adopted additive manufacturing technology (from DIW to digital light processing). MDPI 2021-09-09 /pmc/articles/PMC8468046/ /pubmed/34576394 http://dx.doi.org/10.3390/ma14185170 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dogrul, Fulden
Ożóg, Paulina
Michálek, Martin
Elsayed, Hamada
Galusek, Dušan
Liverani, Liliana
Boccaccini, Aldo R.
Bernardo, Enrico
Polymer-Derived Biosilicate(®)-like Glass-Ceramics: Engineering of Formulations and Additive Manufacturing of Three-Dimensional Scaffolds
title Polymer-Derived Biosilicate(®)-like Glass-Ceramics: Engineering of Formulations and Additive Manufacturing of Three-Dimensional Scaffolds
title_full Polymer-Derived Biosilicate(®)-like Glass-Ceramics: Engineering of Formulations and Additive Manufacturing of Three-Dimensional Scaffolds
title_fullStr Polymer-Derived Biosilicate(®)-like Glass-Ceramics: Engineering of Formulations and Additive Manufacturing of Three-Dimensional Scaffolds
title_full_unstemmed Polymer-Derived Biosilicate(®)-like Glass-Ceramics: Engineering of Formulations and Additive Manufacturing of Three-Dimensional Scaffolds
title_short Polymer-Derived Biosilicate(®)-like Glass-Ceramics: Engineering of Formulations and Additive Manufacturing of Three-Dimensional Scaffolds
title_sort polymer-derived biosilicate(®)-like glass-ceramics: engineering of formulations and additive manufacturing of three-dimensional scaffolds
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468046/
https://www.ncbi.nlm.nih.gov/pubmed/34576394
http://dx.doi.org/10.3390/ma14185170
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