Cargando…

Patient-Reported Outcomes and Preferences for Colon Capsule Endoscopy and Colonoscopy: A Systematic Review with Meta-Analysis

Colon capsule endoscopy as an alternative to colonoscopy for the diagnosis of colonic disease may serve as a less invasive and more tolerable investigation for patients. Our aim was to examine patient-reported outcomes for colon capsule endoscopy compared to conventional optical colonoscopy includin...

Descripción completa

Detalles Bibliográficos
Autores principales: Deding, Ulrik, Cortegoso Valdivia, Pablo, Koulaouzidis, Anastasios, Baatrup, Gunnar, Toth, Ervin, Spada, Cristiano, Fernández-Urién, Ignacio, Pennazio, Marco, Bjørsum-Meyer, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468090/
https://www.ncbi.nlm.nih.gov/pubmed/34574071
http://dx.doi.org/10.3390/diagnostics11091730
_version_ 1784573573086576640
author Deding, Ulrik
Cortegoso Valdivia, Pablo
Koulaouzidis, Anastasios
Baatrup, Gunnar
Toth, Ervin
Spada, Cristiano
Fernández-Urién, Ignacio
Pennazio, Marco
Bjørsum-Meyer, Thomas
author_facet Deding, Ulrik
Cortegoso Valdivia, Pablo
Koulaouzidis, Anastasios
Baatrup, Gunnar
Toth, Ervin
Spada, Cristiano
Fernández-Urién, Ignacio
Pennazio, Marco
Bjørsum-Meyer, Thomas
author_sort Deding, Ulrik
collection PubMed
description Colon capsule endoscopy as an alternative to colonoscopy for the diagnosis of colonic disease may serve as a less invasive and more tolerable investigation for patients. Our aim was to examine patient-reported outcomes for colon capsule endoscopy compared to conventional optical colonoscopy including preference of investigation modality, tolerability and adverse events. A systematic literature search was conducted in Web of Science, PubMed and Embase. Search results were thoroughly screened for in- and exclusion criteria. Included studies underwent assessment of transparency and completeness, after which, data for meta-analysis were extracted. Pooled estimates of patient preference were calculated and heterogeneity was examined including univariate meta-regressions. Patient-reported tolerability and adverse events were reviewed. Out of fourteen included studies, twelve had investigated patient-reported outcomes in patients who had undergone both investigations, whereas in two the patients were randomized between investigations. Pooled patient preferences were estimated to be 52% (CI 95%: 41–63%) for colon capsule endoscopy and 45% (CI 95%: 33–57%) for conventional colonoscopy: not indicating a significant difference. Procedural adverse events were rarely reported by patients for either investigation. The tolerability was high for both colon capsule endoscopy and conventional colonoscopy. Patient preferences for conventional colonoscopy and colon capsule endoscopy were not significantly different. Procedural adverse events were rare and the tolerability for colon capsule endoscopy was consistently reported higher or equal to that of conventional colonoscopy.
format Online
Article
Text
id pubmed-8468090
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-84680902021-09-27 Patient-Reported Outcomes and Preferences for Colon Capsule Endoscopy and Colonoscopy: A Systematic Review with Meta-Analysis Deding, Ulrik Cortegoso Valdivia, Pablo Koulaouzidis, Anastasios Baatrup, Gunnar Toth, Ervin Spada, Cristiano Fernández-Urién, Ignacio Pennazio, Marco Bjørsum-Meyer, Thomas Diagnostics (Basel) Review Colon capsule endoscopy as an alternative to colonoscopy for the diagnosis of colonic disease may serve as a less invasive and more tolerable investigation for patients. Our aim was to examine patient-reported outcomes for colon capsule endoscopy compared to conventional optical colonoscopy including preference of investigation modality, tolerability and adverse events. A systematic literature search was conducted in Web of Science, PubMed and Embase. Search results were thoroughly screened for in- and exclusion criteria. Included studies underwent assessment of transparency and completeness, after which, data for meta-analysis were extracted. Pooled estimates of patient preference were calculated and heterogeneity was examined including univariate meta-regressions. Patient-reported tolerability and adverse events were reviewed. Out of fourteen included studies, twelve had investigated patient-reported outcomes in patients who had undergone both investigations, whereas in two the patients were randomized between investigations. Pooled patient preferences were estimated to be 52% (CI 95%: 41–63%) for colon capsule endoscopy and 45% (CI 95%: 33–57%) for conventional colonoscopy: not indicating a significant difference. Procedural adverse events were rarely reported by patients for either investigation. The tolerability was high for both colon capsule endoscopy and conventional colonoscopy. Patient preferences for conventional colonoscopy and colon capsule endoscopy were not significantly different. Procedural adverse events were rare and the tolerability for colon capsule endoscopy was consistently reported higher or equal to that of conventional colonoscopy. MDPI 2021-09-20 /pmc/articles/PMC8468090/ /pubmed/34574071 http://dx.doi.org/10.3390/diagnostics11091730 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Deding, Ulrik
Cortegoso Valdivia, Pablo
Koulaouzidis, Anastasios
Baatrup, Gunnar
Toth, Ervin
Spada, Cristiano
Fernández-Urién, Ignacio
Pennazio, Marco
Bjørsum-Meyer, Thomas
Patient-Reported Outcomes and Preferences for Colon Capsule Endoscopy and Colonoscopy: A Systematic Review with Meta-Analysis
title Patient-Reported Outcomes and Preferences for Colon Capsule Endoscopy and Colonoscopy: A Systematic Review with Meta-Analysis
title_full Patient-Reported Outcomes and Preferences for Colon Capsule Endoscopy and Colonoscopy: A Systematic Review with Meta-Analysis
title_fullStr Patient-Reported Outcomes and Preferences for Colon Capsule Endoscopy and Colonoscopy: A Systematic Review with Meta-Analysis
title_full_unstemmed Patient-Reported Outcomes and Preferences for Colon Capsule Endoscopy and Colonoscopy: A Systematic Review with Meta-Analysis
title_short Patient-Reported Outcomes and Preferences for Colon Capsule Endoscopy and Colonoscopy: A Systematic Review with Meta-Analysis
title_sort patient-reported outcomes and preferences for colon capsule endoscopy and colonoscopy: a systematic review with meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468090/
https://www.ncbi.nlm.nih.gov/pubmed/34574071
http://dx.doi.org/10.3390/diagnostics11091730
work_keys_str_mv AT dedingulrik patientreportedoutcomesandpreferencesforcoloncapsuleendoscopyandcolonoscopyasystematicreviewwithmetaanalysis
AT cortegosovaldiviapablo patientreportedoutcomesandpreferencesforcoloncapsuleendoscopyandcolonoscopyasystematicreviewwithmetaanalysis
AT koulaouzidisanastasios patientreportedoutcomesandpreferencesforcoloncapsuleendoscopyandcolonoscopyasystematicreviewwithmetaanalysis
AT baatrupgunnar patientreportedoutcomesandpreferencesforcoloncapsuleendoscopyandcolonoscopyasystematicreviewwithmetaanalysis
AT tothervin patientreportedoutcomesandpreferencesforcoloncapsuleendoscopyandcolonoscopyasystematicreviewwithmetaanalysis
AT spadacristiano patientreportedoutcomesandpreferencesforcoloncapsuleendoscopyandcolonoscopyasystematicreviewwithmetaanalysis
AT fernandezurienignacio patientreportedoutcomesandpreferencesforcoloncapsuleendoscopyandcolonoscopyasystematicreviewwithmetaanalysis
AT pennaziomarco patientreportedoutcomesandpreferencesforcoloncapsuleendoscopyandcolonoscopyasystematicreviewwithmetaanalysis
AT bjørsummeyerthomas patientreportedoutcomesandpreferencesforcoloncapsuleendoscopyandcolonoscopyasystematicreviewwithmetaanalysis