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Cognitive and Behavioral Domains That Reliably Differentiate Normal Aging and Dementia in Down Syndrome

Primary care integration of Down syndrome (DS)-specific dementia screening is strongly advised. The current study employed principal components analysis (PCA) and classification and regression tree (CART) analyses to identify an abbreviated battery for dementia classification. Scale- and subscale-le...

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Autores principales: Harp, Jordan P., Koehl, Lisa M., Pelt, Kathryn L. Van, Hom, Christy L., Doran, Eric, Head, Elizabeth, Lott, Ira T., Schmitt, Frederick A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468129/
https://www.ncbi.nlm.nih.gov/pubmed/34573150
http://dx.doi.org/10.3390/brainsci11091128
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author Harp, Jordan P.
Koehl, Lisa M.
Pelt, Kathryn L. Van
Hom, Christy L.
Doran, Eric
Head, Elizabeth
Lott, Ira T.
Schmitt, Frederick A.
author_facet Harp, Jordan P.
Koehl, Lisa M.
Pelt, Kathryn L. Van
Hom, Christy L.
Doran, Eric
Head, Elizabeth
Lott, Ira T.
Schmitt, Frederick A.
author_sort Harp, Jordan P.
collection PubMed
description Primary care integration of Down syndrome (DS)-specific dementia screening is strongly advised. The current study employed principal components analysis (PCA) and classification and regression tree (CART) analyses to identify an abbreviated battery for dementia classification. Scale- and subscale-level scores from 141 participants (no dementia n = 68; probable Alzheimer’s disease n = 73), for the Severe Impairment Battery (SIB), Dementia Scale for People with Learning Disabilities (DLD), and Vineland Adaptive Behavior Scales—Second Edition (Vineland-II) were analyzed. Two principle components (PC1, PC2) were identified with the odds of a probable dementia diagnosis increasing 2.54 times per PC1 unit increase and by 3.73 times per PC2 unit increase. CART analysis identified that the DLD sum of cognitive scores (SCS < 35 raw) and Vineland-II community subdomain (<36 raw) scores best classified dementia. No significant difference in the PCA versus CART area under the curve (AUC) was noted (D(65.196) = −0.57683; p = 0.57; PCA AUC = 0.87; CART AUC = 0.91). The PCA sensitivity was 80% and specificity was 70%; CART was 100% and specificity was 81%. These results support an abbreviated dementia screening battery to identify at-risk individuals with DS in primary care settings to guide specialized diagnostic referral.
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spelling pubmed-84681292021-09-27 Cognitive and Behavioral Domains That Reliably Differentiate Normal Aging and Dementia in Down Syndrome Harp, Jordan P. Koehl, Lisa M. Pelt, Kathryn L. Van Hom, Christy L. Doran, Eric Head, Elizabeth Lott, Ira T. Schmitt, Frederick A. Brain Sci Article Primary care integration of Down syndrome (DS)-specific dementia screening is strongly advised. The current study employed principal components analysis (PCA) and classification and regression tree (CART) analyses to identify an abbreviated battery for dementia classification. Scale- and subscale-level scores from 141 participants (no dementia n = 68; probable Alzheimer’s disease n = 73), for the Severe Impairment Battery (SIB), Dementia Scale for People with Learning Disabilities (DLD), and Vineland Adaptive Behavior Scales—Second Edition (Vineland-II) were analyzed. Two principle components (PC1, PC2) were identified with the odds of a probable dementia diagnosis increasing 2.54 times per PC1 unit increase and by 3.73 times per PC2 unit increase. CART analysis identified that the DLD sum of cognitive scores (SCS < 35 raw) and Vineland-II community subdomain (<36 raw) scores best classified dementia. No significant difference in the PCA versus CART area under the curve (AUC) was noted (D(65.196) = −0.57683; p = 0.57; PCA AUC = 0.87; CART AUC = 0.91). The PCA sensitivity was 80% and specificity was 70%; CART was 100% and specificity was 81%. These results support an abbreviated dementia screening battery to identify at-risk individuals with DS in primary care settings to guide specialized diagnostic referral. MDPI 2021-08-25 /pmc/articles/PMC8468129/ /pubmed/34573150 http://dx.doi.org/10.3390/brainsci11091128 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Harp, Jordan P.
Koehl, Lisa M.
Pelt, Kathryn L. Van
Hom, Christy L.
Doran, Eric
Head, Elizabeth
Lott, Ira T.
Schmitt, Frederick A.
Cognitive and Behavioral Domains That Reliably Differentiate Normal Aging and Dementia in Down Syndrome
title Cognitive and Behavioral Domains That Reliably Differentiate Normal Aging and Dementia in Down Syndrome
title_full Cognitive and Behavioral Domains That Reliably Differentiate Normal Aging and Dementia in Down Syndrome
title_fullStr Cognitive and Behavioral Domains That Reliably Differentiate Normal Aging and Dementia in Down Syndrome
title_full_unstemmed Cognitive and Behavioral Domains That Reliably Differentiate Normal Aging and Dementia in Down Syndrome
title_short Cognitive and Behavioral Domains That Reliably Differentiate Normal Aging and Dementia in Down Syndrome
title_sort cognitive and behavioral domains that reliably differentiate normal aging and dementia in down syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468129/
https://www.ncbi.nlm.nih.gov/pubmed/34573150
http://dx.doi.org/10.3390/brainsci11091128
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