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Cognitive and Behavioral Domains That Reliably Differentiate Normal Aging and Dementia in Down Syndrome
Primary care integration of Down syndrome (DS)-specific dementia screening is strongly advised. The current study employed principal components analysis (PCA) and classification and regression tree (CART) analyses to identify an abbreviated battery for dementia classification. Scale- and subscale-le...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468129/ https://www.ncbi.nlm.nih.gov/pubmed/34573150 http://dx.doi.org/10.3390/brainsci11091128 |
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author | Harp, Jordan P. Koehl, Lisa M. Pelt, Kathryn L. Van Hom, Christy L. Doran, Eric Head, Elizabeth Lott, Ira T. Schmitt, Frederick A. |
author_facet | Harp, Jordan P. Koehl, Lisa M. Pelt, Kathryn L. Van Hom, Christy L. Doran, Eric Head, Elizabeth Lott, Ira T. Schmitt, Frederick A. |
author_sort | Harp, Jordan P. |
collection | PubMed |
description | Primary care integration of Down syndrome (DS)-specific dementia screening is strongly advised. The current study employed principal components analysis (PCA) and classification and regression tree (CART) analyses to identify an abbreviated battery for dementia classification. Scale- and subscale-level scores from 141 participants (no dementia n = 68; probable Alzheimer’s disease n = 73), for the Severe Impairment Battery (SIB), Dementia Scale for People with Learning Disabilities (DLD), and Vineland Adaptive Behavior Scales—Second Edition (Vineland-II) were analyzed. Two principle components (PC1, PC2) were identified with the odds of a probable dementia diagnosis increasing 2.54 times per PC1 unit increase and by 3.73 times per PC2 unit increase. CART analysis identified that the DLD sum of cognitive scores (SCS < 35 raw) and Vineland-II community subdomain (<36 raw) scores best classified dementia. No significant difference in the PCA versus CART area under the curve (AUC) was noted (D(65.196) = −0.57683; p = 0.57; PCA AUC = 0.87; CART AUC = 0.91). The PCA sensitivity was 80% and specificity was 70%; CART was 100% and specificity was 81%. These results support an abbreviated dementia screening battery to identify at-risk individuals with DS in primary care settings to guide specialized diagnostic referral. |
format | Online Article Text |
id | pubmed-8468129 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84681292021-09-27 Cognitive and Behavioral Domains That Reliably Differentiate Normal Aging and Dementia in Down Syndrome Harp, Jordan P. Koehl, Lisa M. Pelt, Kathryn L. Van Hom, Christy L. Doran, Eric Head, Elizabeth Lott, Ira T. Schmitt, Frederick A. Brain Sci Article Primary care integration of Down syndrome (DS)-specific dementia screening is strongly advised. The current study employed principal components analysis (PCA) and classification and regression tree (CART) analyses to identify an abbreviated battery for dementia classification. Scale- and subscale-level scores from 141 participants (no dementia n = 68; probable Alzheimer’s disease n = 73), for the Severe Impairment Battery (SIB), Dementia Scale for People with Learning Disabilities (DLD), and Vineland Adaptive Behavior Scales—Second Edition (Vineland-II) were analyzed. Two principle components (PC1, PC2) were identified with the odds of a probable dementia diagnosis increasing 2.54 times per PC1 unit increase and by 3.73 times per PC2 unit increase. CART analysis identified that the DLD sum of cognitive scores (SCS < 35 raw) and Vineland-II community subdomain (<36 raw) scores best classified dementia. No significant difference in the PCA versus CART area under the curve (AUC) was noted (D(65.196) = −0.57683; p = 0.57; PCA AUC = 0.87; CART AUC = 0.91). The PCA sensitivity was 80% and specificity was 70%; CART was 100% and specificity was 81%. These results support an abbreviated dementia screening battery to identify at-risk individuals with DS in primary care settings to guide specialized diagnostic referral. MDPI 2021-08-25 /pmc/articles/PMC8468129/ /pubmed/34573150 http://dx.doi.org/10.3390/brainsci11091128 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Harp, Jordan P. Koehl, Lisa M. Pelt, Kathryn L. Van Hom, Christy L. Doran, Eric Head, Elizabeth Lott, Ira T. Schmitt, Frederick A. Cognitive and Behavioral Domains That Reliably Differentiate Normal Aging and Dementia in Down Syndrome |
title | Cognitive and Behavioral Domains That Reliably Differentiate Normal Aging and Dementia in Down Syndrome |
title_full | Cognitive and Behavioral Domains That Reliably Differentiate Normal Aging and Dementia in Down Syndrome |
title_fullStr | Cognitive and Behavioral Domains That Reliably Differentiate Normal Aging and Dementia in Down Syndrome |
title_full_unstemmed | Cognitive and Behavioral Domains That Reliably Differentiate Normal Aging and Dementia in Down Syndrome |
title_short | Cognitive and Behavioral Domains That Reliably Differentiate Normal Aging and Dementia in Down Syndrome |
title_sort | cognitive and behavioral domains that reliably differentiate normal aging and dementia in down syndrome |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468129/ https://www.ncbi.nlm.nih.gov/pubmed/34573150 http://dx.doi.org/10.3390/brainsci11091128 |
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