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ABO Incompatible Liver Transplantation in Children: A 20 Year Experience from Centres in the TransplantChild European Reference Network
An increasing number of AB0-incompatible (AB0i) liver transplantations (LT) are being undertaken internationally in recent years due to organ shortages and the need for urgent transplantation. The aim of our study was establish the value of ABOi LT from available retrospective results of AB0i pediat...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468154/ https://www.ncbi.nlm.nih.gov/pubmed/34572193 http://dx.doi.org/10.3390/children8090760 |
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author | Markiewicz-Kijewska, Małgorzata Kaliciński, Piotr Torres Canizales, Juan Di Giorgio, Angelo Baumann, Ulrich Jorns, Carl Baker, Alastair Lopes, Maria Francelina Frauca Remacha, Esteban Lopez-Granados, Eduardo Jara Vega, Paloma Basso, Maria-Sole Kowalewski, Grzegorz Kamińska, Diana Ferreira, Sandra Liccardo, Daniela Pietrobattista, Andrea Spada, Marco |
author_facet | Markiewicz-Kijewska, Małgorzata Kaliciński, Piotr Torres Canizales, Juan Di Giorgio, Angelo Baumann, Ulrich Jorns, Carl Baker, Alastair Lopes, Maria Francelina Frauca Remacha, Esteban Lopez-Granados, Eduardo Jara Vega, Paloma Basso, Maria-Sole Kowalewski, Grzegorz Kamińska, Diana Ferreira, Sandra Liccardo, Daniela Pietrobattista, Andrea Spada, Marco |
author_sort | Markiewicz-Kijewska, Małgorzata |
collection | PubMed |
description | An increasing number of AB0-incompatible (AB0i) liver transplantations (LT) are being undertaken internationally in recent years due to organ shortages and the need for urgent transplantation. The aim of our study was establish the value of ABOi LT from available retrospective results of AB0i pediatric liver transplantations performed in European reference centers now belonging to the TransplantChild, European Reference Network (ERN). Data from medical records were analyzed, including demographic data, diagnosis, urgency of transplantation, time on the waiting list, PELD/MELD score, desensitization procedures, immunosuppression, selected post-transplant complications, and patient and graft survival. A total of 142 patients (pts) with transplants between 1986 and 2018 in 8 European transplant centers were included in the study. The indications for liver transplantation were: cholestatic diseases in 62 pts, acute liver failure in 42 pts, and other conditions in the remaining 38 pts. Sixty-six patients received grafts from living donors, and seventy-six received grafts from deceased donors. Both patient and graft survival were significantly affected by deceased donor type, urgent transplantation, and the development of vascular complications. In the multivariate analysis, vascular complications had a negative impact on patient and graft survival, while a longer time from the first AB0i LT in the study showed better results, suggesting an international learning experience. In conclusion, we believe that AB0i LT in children is now a safe procedure that may be adopted more readily in children. |
format | Online Article Text |
id | pubmed-8468154 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84681542021-09-27 ABO Incompatible Liver Transplantation in Children: A 20 Year Experience from Centres in the TransplantChild European Reference Network Markiewicz-Kijewska, Małgorzata Kaliciński, Piotr Torres Canizales, Juan Di Giorgio, Angelo Baumann, Ulrich Jorns, Carl Baker, Alastair Lopes, Maria Francelina Frauca Remacha, Esteban Lopez-Granados, Eduardo Jara Vega, Paloma Basso, Maria-Sole Kowalewski, Grzegorz Kamińska, Diana Ferreira, Sandra Liccardo, Daniela Pietrobattista, Andrea Spada, Marco Children (Basel) Article An increasing number of AB0-incompatible (AB0i) liver transplantations (LT) are being undertaken internationally in recent years due to organ shortages and the need for urgent transplantation. The aim of our study was establish the value of ABOi LT from available retrospective results of AB0i pediatric liver transplantations performed in European reference centers now belonging to the TransplantChild, European Reference Network (ERN). Data from medical records were analyzed, including demographic data, diagnosis, urgency of transplantation, time on the waiting list, PELD/MELD score, desensitization procedures, immunosuppression, selected post-transplant complications, and patient and graft survival. A total of 142 patients (pts) with transplants between 1986 and 2018 in 8 European transplant centers were included in the study. The indications for liver transplantation were: cholestatic diseases in 62 pts, acute liver failure in 42 pts, and other conditions in the remaining 38 pts. Sixty-six patients received grafts from living donors, and seventy-six received grafts from deceased donors. Both patient and graft survival were significantly affected by deceased donor type, urgent transplantation, and the development of vascular complications. In the multivariate analysis, vascular complications had a negative impact on patient and graft survival, while a longer time from the first AB0i LT in the study showed better results, suggesting an international learning experience. In conclusion, we believe that AB0i LT in children is now a safe procedure that may be adopted more readily in children. MDPI 2021-08-31 /pmc/articles/PMC8468154/ /pubmed/34572193 http://dx.doi.org/10.3390/children8090760 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Markiewicz-Kijewska, Małgorzata Kaliciński, Piotr Torres Canizales, Juan Di Giorgio, Angelo Baumann, Ulrich Jorns, Carl Baker, Alastair Lopes, Maria Francelina Frauca Remacha, Esteban Lopez-Granados, Eduardo Jara Vega, Paloma Basso, Maria-Sole Kowalewski, Grzegorz Kamińska, Diana Ferreira, Sandra Liccardo, Daniela Pietrobattista, Andrea Spada, Marco ABO Incompatible Liver Transplantation in Children: A 20 Year Experience from Centres in the TransplantChild European Reference Network |
title | ABO Incompatible Liver Transplantation in Children: A 20 Year Experience from Centres in the TransplantChild European Reference Network |
title_full | ABO Incompatible Liver Transplantation in Children: A 20 Year Experience from Centres in the TransplantChild European Reference Network |
title_fullStr | ABO Incompatible Liver Transplantation in Children: A 20 Year Experience from Centres in the TransplantChild European Reference Network |
title_full_unstemmed | ABO Incompatible Liver Transplantation in Children: A 20 Year Experience from Centres in the TransplantChild European Reference Network |
title_short | ABO Incompatible Liver Transplantation in Children: A 20 Year Experience from Centres in the TransplantChild European Reference Network |
title_sort | abo incompatible liver transplantation in children: a 20 year experience from centres in the transplantchild european reference network |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468154/ https://www.ncbi.nlm.nih.gov/pubmed/34572193 http://dx.doi.org/10.3390/children8090760 |
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