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ABO Incompatible Liver Transplantation in Children: A 20 Year Experience from Centres in the TransplantChild European Reference Network

An increasing number of AB0-incompatible (AB0i) liver transplantations (LT) are being undertaken internationally in recent years due to organ shortages and the need for urgent transplantation. The aim of our study was establish the value of ABOi LT from available retrospective results of AB0i pediat...

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Autores principales: Markiewicz-Kijewska, Małgorzata, Kaliciński, Piotr, Torres Canizales, Juan, Di Giorgio, Angelo, Baumann, Ulrich, Jorns, Carl, Baker, Alastair, Lopes, Maria Francelina, Frauca Remacha, Esteban, Lopez-Granados, Eduardo, Jara Vega, Paloma, Basso, Maria-Sole, Kowalewski, Grzegorz, Kamińska, Diana, Ferreira, Sandra, Liccardo, Daniela, Pietrobattista, Andrea, Spada, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468154/
https://www.ncbi.nlm.nih.gov/pubmed/34572193
http://dx.doi.org/10.3390/children8090760
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author Markiewicz-Kijewska, Małgorzata
Kaliciński, Piotr
Torres Canizales, Juan
Di Giorgio, Angelo
Baumann, Ulrich
Jorns, Carl
Baker, Alastair
Lopes, Maria Francelina
Frauca Remacha, Esteban
Lopez-Granados, Eduardo
Jara Vega, Paloma
Basso, Maria-Sole
Kowalewski, Grzegorz
Kamińska, Diana
Ferreira, Sandra
Liccardo, Daniela
Pietrobattista, Andrea
Spada, Marco
author_facet Markiewicz-Kijewska, Małgorzata
Kaliciński, Piotr
Torres Canizales, Juan
Di Giorgio, Angelo
Baumann, Ulrich
Jorns, Carl
Baker, Alastair
Lopes, Maria Francelina
Frauca Remacha, Esteban
Lopez-Granados, Eduardo
Jara Vega, Paloma
Basso, Maria-Sole
Kowalewski, Grzegorz
Kamińska, Diana
Ferreira, Sandra
Liccardo, Daniela
Pietrobattista, Andrea
Spada, Marco
author_sort Markiewicz-Kijewska, Małgorzata
collection PubMed
description An increasing number of AB0-incompatible (AB0i) liver transplantations (LT) are being undertaken internationally in recent years due to organ shortages and the need for urgent transplantation. The aim of our study was establish the value of ABOi LT from available retrospective results of AB0i pediatric liver transplantations performed in European reference centers now belonging to the TransplantChild, European Reference Network (ERN). Data from medical records were analyzed, including demographic data, diagnosis, urgency of transplantation, time on the waiting list, PELD/MELD score, desensitization procedures, immunosuppression, selected post-transplant complications, and patient and graft survival. A total of 142 patients (pts) with transplants between 1986 and 2018 in 8 European transplant centers were included in the study. The indications for liver transplantation were: cholestatic diseases in 62 pts, acute liver failure in 42 pts, and other conditions in the remaining 38 pts. Sixty-six patients received grafts from living donors, and seventy-six received grafts from deceased donors. Both patient and graft survival were significantly affected by deceased donor type, urgent transplantation, and the development of vascular complications. In the multivariate analysis, vascular complications had a negative impact on patient and graft survival, while a longer time from the first AB0i LT in the study showed better results, suggesting an international learning experience. In conclusion, we believe that AB0i LT in children is now a safe procedure that may be adopted more readily in children.
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spelling pubmed-84681542021-09-27 ABO Incompatible Liver Transplantation in Children: A 20 Year Experience from Centres in the TransplantChild European Reference Network Markiewicz-Kijewska, Małgorzata Kaliciński, Piotr Torres Canizales, Juan Di Giorgio, Angelo Baumann, Ulrich Jorns, Carl Baker, Alastair Lopes, Maria Francelina Frauca Remacha, Esteban Lopez-Granados, Eduardo Jara Vega, Paloma Basso, Maria-Sole Kowalewski, Grzegorz Kamińska, Diana Ferreira, Sandra Liccardo, Daniela Pietrobattista, Andrea Spada, Marco Children (Basel) Article An increasing number of AB0-incompatible (AB0i) liver transplantations (LT) are being undertaken internationally in recent years due to organ shortages and the need for urgent transplantation. The aim of our study was establish the value of ABOi LT from available retrospective results of AB0i pediatric liver transplantations performed in European reference centers now belonging to the TransplantChild, European Reference Network (ERN). Data from medical records were analyzed, including demographic data, diagnosis, urgency of transplantation, time on the waiting list, PELD/MELD score, desensitization procedures, immunosuppression, selected post-transplant complications, and patient and graft survival. A total of 142 patients (pts) with transplants between 1986 and 2018 in 8 European transplant centers were included in the study. The indications for liver transplantation were: cholestatic diseases in 62 pts, acute liver failure in 42 pts, and other conditions in the remaining 38 pts. Sixty-six patients received grafts from living donors, and seventy-six received grafts from deceased donors. Both patient and graft survival were significantly affected by deceased donor type, urgent transplantation, and the development of vascular complications. In the multivariate analysis, vascular complications had a negative impact on patient and graft survival, while a longer time from the first AB0i LT in the study showed better results, suggesting an international learning experience. In conclusion, we believe that AB0i LT in children is now a safe procedure that may be adopted more readily in children. MDPI 2021-08-31 /pmc/articles/PMC8468154/ /pubmed/34572193 http://dx.doi.org/10.3390/children8090760 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Markiewicz-Kijewska, Małgorzata
Kaliciński, Piotr
Torres Canizales, Juan
Di Giorgio, Angelo
Baumann, Ulrich
Jorns, Carl
Baker, Alastair
Lopes, Maria Francelina
Frauca Remacha, Esteban
Lopez-Granados, Eduardo
Jara Vega, Paloma
Basso, Maria-Sole
Kowalewski, Grzegorz
Kamińska, Diana
Ferreira, Sandra
Liccardo, Daniela
Pietrobattista, Andrea
Spada, Marco
ABO Incompatible Liver Transplantation in Children: A 20 Year Experience from Centres in the TransplantChild European Reference Network
title ABO Incompatible Liver Transplantation in Children: A 20 Year Experience from Centres in the TransplantChild European Reference Network
title_full ABO Incompatible Liver Transplantation in Children: A 20 Year Experience from Centres in the TransplantChild European Reference Network
title_fullStr ABO Incompatible Liver Transplantation in Children: A 20 Year Experience from Centres in the TransplantChild European Reference Network
title_full_unstemmed ABO Incompatible Liver Transplantation in Children: A 20 Year Experience from Centres in the TransplantChild European Reference Network
title_short ABO Incompatible Liver Transplantation in Children: A 20 Year Experience from Centres in the TransplantChild European Reference Network
title_sort abo incompatible liver transplantation in children: a 20 year experience from centres in the transplantchild european reference network
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468154/
https://www.ncbi.nlm.nih.gov/pubmed/34572193
http://dx.doi.org/10.3390/children8090760
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