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Beyond the GFAP-Astrocyte Protein Markers in the Brain

The idea of central nervous system as one-man band favoring neurons is long gone. Now we all are aware that neurons and neuroglia are team players and constant communication between those various cell types is essential to maintain functional efficiency and a quick response to danger. Here, we summa...

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Autores principales: Jurga, Agnieszka M., Paleczna, Martyna, Kadluczka, Justyna, Kuter, Katarzyna Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468264/
https://www.ncbi.nlm.nih.gov/pubmed/34572572
http://dx.doi.org/10.3390/biom11091361
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author Jurga, Agnieszka M.
Paleczna, Martyna
Kadluczka, Justyna
Kuter, Katarzyna Z.
author_facet Jurga, Agnieszka M.
Paleczna, Martyna
Kadluczka, Justyna
Kuter, Katarzyna Z.
author_sort Jurga, Agnieszka M.
collection PubMed
description The idea of central nervous system as one-man band favoring neurons is long gone. Now we all are aware that neurons and neuroglia are team players and constant communication between those various cell types is essential to maintain functional efficiency and a quick response to danger. Here, we summarize and discuss known and new markers of astroglial multiple functions, their natural heterogeneity, cellular interactions, aging and disease-induced dysfunctions. This review is focused on newly reported facts regarding astrocytes, which are beyond the old stereotypes. We present an up-to-date list of marker proteins used to identify a broad spectrum of astroglial phenotypes related to the various physiological and pathological nervous system conditions. The aim of this review is to help choose markers that are well-tailored for specific needs of further experimental studies, precisely recognizing differential glial phenotypes, or for diagnostic purposes. We hope it will help to categorize the functional and structural diversity of the astroglial population and ease a clear readout of future experimental results.
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spelling pubmed-84682642021-09-27 Beyond the GFAP-Astrocyte Protein Markers in the Brain Jurga, Agnieszka M. Paleczna, Martyna Kadluczka, Justyna Kuter, Katarzyna Z. Biomolecules Review The idea of central nervous system as one-man band favoring neurons is long gone. Now we all are aware that neurons and neuroglia are team players and constant communication between those various cell types is essential to maintain functional efficiency and a quick response to danger. Here, we summarize and discuss known and new markers of astroglial multiple functions, their natural heterogeneity, cellular interactions, aging and disease-induced dysfunctions. This review is focused on newly reported facts regarding astrocytes, which are beyond the old stereotypes. We present an up-to-date list of marker proteins used to identify a broad spectrum of astroglial phenotypes related to the various physiological and pathological nervous system conditions. The aim of this review is to help choose markers that are well-tailored for specific needs of further experimental studies, precisely recognizing differential glial phenotypes, or for diagnostic purposes. We hope it will help to categorize the functional and structural diversity of the astroglial population and ease a clear readout of future experimental results. MDPI 2021-09-14 /pmc/articles/PMC8468264/ /pubmed/34572572 http://dx.doi.org/10.3390/biom11091361 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jurga, Agnieszka M.
Paleczna, Martyna
Kadluczka, Justyna
Kuter, Katarzyna Z.
Beyond the GFAP-Astrocyte Protein Markers in the Brain
title Beyond the GFAP-Astrocyte Protein Markers in the Brain
title_full Beyond the GFAP-Astrocyte Protein Markers in the Brain
title_fullStr Beyond the GFAP-Astrocyte Protein Markers in the Brain
title_full_unstemmed Beyond the GFAP-Astrocyte Protein Markers in the Brain
title_short Beyond the GFAP-Astrocyte Protein Markers in the Brain
title_sort beyond the gfap-astrocyte protein markers in the brain
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468264/
https://www.ncbi.nlm.nih.gov/pubmed/34572572
http://dx.doi.org/10.3390/biom11091361
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