A Curious Novel Combination of Nucleophosmin (NPM1) Gene Mutations Leading to Aberrant Cytoplasmic Dislocation of NPM1 in Acute Myeloid Leukemia (AML)

Nucleophosmin (NPM1) mutations occurring in acute myeloid leukemia (AML) (about 50 so far identified) cluster almost exclusively in exon 12 and lead to common changes at the NPM1 mutants C-terminus, i.e., loss of tryptophans 288 and 290 (or 290 alone) and creation of a new nuclear export signal (NES...

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Detalles Bibliográficos
Autores principales: Venanzi, Alessandra, Rossi, Roberta, Martino, Giovanni, Annibali, Ombretta, Avvisati, Giuseppe, Mameli, Maria Grazia, Sportoletti, Paolo, Tiacci, Enrico, Falini, Brunangelo, Martelli, Maria Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468273/
https://www.ncbi.nlm.nih.gov/pubmed/34573408
http://dx.doi.org/10.3390/genes12091426

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468273/
https://www.ncbi.nlm.nih.gov/pubmed/34573408
http://dx.doi.org/10.3390/genes12091426

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