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Impaired HMG-CoA Reductase Activity Caused by Genetic Variants or Statin Exposure: Impact on Human Adipose Tissue, β-Cells and Metabolome

Inhibition of 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase is associated with an increased risk of new-onset type 2 diabetes. We studied the association of genetic or pharmacological HMG-CoA reductase inhibition with plasma and adipose tissue (AT) metabolome and AT metabolic pathways. We also...

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Detalles Bibliográficos
Autores principales:	Sarsenbayeva, Assel, Jui, Bipasha Nandi, Fanni, Giovanni, Barbosa, Pedro, Ahmed, Fozia, Kristófi, Robin, Cen, Jing, Chowdhury, Azazul, Skrtic, Stanko, Bergsten, Peter, Fall, Tove, Eriksson, Jan W., Pereira, Maria J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468287/ https://www.ncbi.nlm.nih.gov/pubmed/34564389 http://dx.doi.org/10.3390/metabo11090574

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