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Drosophila Accessory Gland: A Complementary In Vivo Model to Bring New Insight to Prostate Cancer
Prostate cancer is the most common cancer in aging men. Despite recent progress, there are still few effective treatments to cure its aggressive and metastatic stages. A better understanding of the molecular mechanisms driving disease initiation and progression appears essential to support the devel...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468328/ https://www.ncbi.nlm.nih.gov/pubmed/34572036 http://dx.doi.org/10.3390/cells10092387 |
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author | Rambur, Amandine Vialat, Marine Beaudoin, Claude Lours-Calet, Corinne Lobaccaro, Jean-Marc Baron, Silvère Morel, Laurent de Joussineau, Cyrille |
author_facet | Rambur, Amandine Vialat, Marine Beaudoin, Claude Lours-Calet, Corinne Lobaccaro, Jean-Marc Baron, Silvère Morel, Laurent de Joussineau, Cyrille |
author_sort | Rambur, Amandine |
collection | PubMed |
description | Prostate cancer is the most common cancer in aging men. Despite recent progress, there are still few effective treatments to cure its aggressive and metastatic stages. A better understanding of the molecular mechanisms driving disease initiation and progression appears essential to support the development of more efficient therapies and improve patient care. To do so, multiple research models, such as cell culture and mouse models, have been developed over the years and have improved our comprehension of the biology of the disease. Recently, a new model has been added with the use of the Drosophila accessory gland. With a high level of conservation of major signaling pathways implicated in human disease, this functional equivalent of the prostate represents a powerful, inexpensive, and rapid in vivo model to study epithelial carcinogenesis. The purpose of this review is to quickly overview the existing prostate cancer models, including their strengths and limitations. In particular, we discuss how the Drosophila accessory gland can be integrated as a convenient complementary model by bringing new understanding in the mechanisms driving prostate epithelial tumorigenesis, from initiation to metastatic formation. |
format | Online Article Text |
id | pubmed-8468328 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84683282021-09-27 Drosophila Accessory Gland: A Complementary In Vivo Model to Bring New Insight to Prostate Cancer Rambur, Amandine Vialat, Marine Beaudoin, Claude Lours-Calet, Corinne Lobaccaro, Jean-Marc Baron, Silvère Morel, Laurent de Joussineau, Cyrille Cells Review Prostate cancer is the most common cancer in aging men. Despite recent progress, there are still few effective treatments to cure its aggressive and metastatic stages. A better understanding of the molecular mechanisms driving disease initiation and progression appears essential to support the development of more efficient therapies and improve patient care. To do so, multiple research models, such as cell culture and mouse models, have been developed over the years and have improved our comprehension of the biology of the disease. Recently, a new model has been added with the use of the Drosophila accessory gland. With a high level of conservation of major signaling pathways implicated in human disease, this functional equivalent of the prostate represents a powerful, inexpensive, and rapid in vivo model to study epithelial carcinogenesis. The purpose of this review is to quickly overview the existing prostate cancer models, including their strengths and limitations. In particular, we discuss how the Drosophila accessory gland can be integrated as a convenient complementary model by bringing new understanding in the mechanisms driving prostate epithelial tumorigenesis, from initiation to metastatic formation. MDPI 2021-09-10 /pmc/articles/PMC8468328/ /pubmed/34572036 http://dx.doi.org/10.3390/cells10092387 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Rambur, Amandine Vialat, Marine Beaudoin, Claude Lours-Calet, Corinne Lobaccaro, Jean-Marc Baron, Silvère Morel, Laurent de Joussineau, Cyrille Drosophila Accessory Gland: A Complementary In Vivo Model to Bring New Insight to Prostate Cancer |
title | Drosophila Accessory Gland: A Complementary In Vivo Model to Bring New Insight to Prostate Cancer |
title_full | Drosophila Accessory Gland: A Complementary In Vivo Model to Bring New Insight to Prostate Cancer |
title_fullStr | Drosophila Accessory Gland: A Complementary In Vivo Model to Bring New Insight to Prostate Cancer |
title_full_unstemmed | Drosophila Accessory Gland: A Complementary In Vivo Model to Bring New Insight to Prostate Cancer |
title_short | Drosophila Accessory Gland: A Complementary In Vivo Model to Bring New Insight to Prostate Cancer |
title_sort | drosophila accessory gland: a complementary in vivo model to bring new insight to prostate cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468328/ https://www.ncbi.nlm.nih.gov/pubmed/34572036 http://dx.doi.org/10.3390/cells10092387 |
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