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Drosophila Accessory Gland: A Complementary In Vivo Model to Bring New Insight to Prostate Cancer

Prostate cancer is the most common cancer in aging men. Despite recent progress, there are still few effective treatments to cure its aggressive and metastatic stages. A better understanding of the molecular mechanisms driving disease initiation and progression appears essential to support the devel...

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Autores principales: Rambur, Amandine, Vialat, Marine, Beaudoin, Claude, Lours-Calet, Corinne, Lobaccaro, Jean-Marc, Baron, Silvère, Morel, Laurent, de Joussineau, Cyrille
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468328/
https://www.ncbi.nlm.nih.gov/pubmed/34572036
http://dx.doi.org/10.3390/cells10092387
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author Rambur, Amandine
Vialat, Marine
Beaudoin, Claude
Lours-Calet, Corinne
Lobaccaro, Jean-Marc
Baron, Silvère
Morel, Laurent
de Joussineau, Cyrille
author_facet Rambur, Amandine
Vialat, Marine
Beaudoin, Claude
Lours-Calet, Corinne
Lobaccaro, Jean-Marc
Baron, Silvère
Morel, Laurent
de Joussineau, Cyrille
author_sort Rambur, Amandine
collection PubMed
description Prostate cancer is the most common cancer in aging men. Despite recent progress, there are still few effective treatments to cure its aggressive and metastatic stages. A better understanding of the molecular mechanisms driving disease initiation and progression appears essential to support the development of more efficient therapies and improve patient care. To do so, multiple research models, such as cell culture and mouse models, have been developed over the years and have improved our comprehension of the biology of the disease. Recently, a new model has been added with the use of the Drosophila accessory gland. With a high level of conservation of major signaling pathways implicated in human disease, this functional equivalent of the prostate represents a powerful, inexpensive, and rapid in vivo model to study epithelial carcinogenesis. The purpose of this review is to quickly overview the existing prostate cancer models, including their strengths and limitations. In particular, we discuss how the Drosophila accessory gland can be integrated as a convenient complementary model by bringing new understanding in the mechanisms driving prostate epithelial tumorigenesis, from initiation to metastatic formation.
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spelling pubmed-84683282021-09-27 Drosophila Accessory Gland: A Complementary In Vivo Model to Bring New Insight to Prostate Cancer Rambur, Amandine Vialat, Marine Beaudoin, Claude Lours-Calet, Corinne Lobaccaro, Jean-Marc Baron, Silvère Morel, Laurent de Joussineau, Cyrille Cells Review Prostate cancer is the most common cancer in aging men. Despite recent progress, there are still few effective treatments to cure its aggressive and metastatic stages. A better understanding of the molecular mechanisms driving disease initiation and progression appears essential to support the development of more efficient therapies and improve patient care. To do so, multiple research models, such as cell culture and mouse models, have been developed over the years and have improved our comprehension of the biology of the disease. Recently, a new model has been added with the use of the Drosophila accessory gland. With a high level of conservation of major signaling pathways implicated in human disease, this functional equivalent of the prostate represents a powerful, inexpensive, and rapid in vivo model to study epithelial carcinogenesis. The purpose of this review is to quickly overview the existing prostate cancer models, including their strengths and limitations. In particular, we discuss how the Drosophila accessory gland can be integrated as a convenient complementary model by bringing new understanding in the mechanisms driving prostate epithelial tumorigenesis, from initiation to metastatic formation. MDPI 2021-09-10 /pmc/articles/PMC8468328/ /pubmed/34572036 http://dx.doi.org/10.3390/cells10092387 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rambur, Amandine
Vialat, Marine
Beaudoin, Claude
Lours-Calet, Corinne
Lobaccaro, Jean-Marc
Baron, Silvère
Morel, Laurent
de Joussineau, Cyrille
Drosophila Accessory Gland: A Complementary In Vivo Model to Bring New Insight to Prostate Cancer
title Drosophila Accessory Gland: A Complementary In Vivo Model to Bring New Insight to Prostate Cancer
title_full Drosophila Accessory Gland: A Complementary In Vivo Model to Bring New Insight to Prostate Cancer
title_fullStr Drosophila Accessory Gland: A Complementary In Vivo Model to Bring New Insight to Prostate Cancer
title_full_unstemmed Drosophila Accessory Gland: A Complementary In Vivo Model to Bring New Insight to Prostate Cancer
title_short Drosophila Accessory Gland: A Complementary In Vivo Model to Bring New Insight to Prostate Cancer
title_sort drosophila accessory gland: a complementary in vivo model to bring new insight to prostate cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468328/
https://www.ncbi.nlm.nih.gov/pubmed/34572036
http://dx.doi.org/10.3390/cells10092387
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