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Antimicrobial, Antioxidant and Antiproliferative Secondary Metabolites from Inonotus nidus-pici
Inonotus nidus-pici is a sterile conk which produces macrofungus, a neglected Central-Eastern European relative of the prized Inonotus obliquus, also known as chaga. Investigation of the methanol extract of the poroid fungus I. nidus-pici resulted in the isolation of citropremide (1), 3,4-dihydroxyb...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468361/ https://www.ncbi.nlm.nih.gov/pubmed/34576923 http://dx.doi.org/10.3390/molecules26185453 |
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author | Garádi, Zsófia Dékány, Miklós Móricz, Ágnes M. Gaál, Anikó Papp, Viktor Béni, Szabolcs Ványolós, Attila |
author_facet | Garádi, Zsófia Dékány, Miklós Móricz, Ágnes M. Gaál, Anikó Papp, Viktor Béni, Szabolcs Ványolós, Attila |
author_sort | Garádi, Zsófia |
collection | PubMed |
description | Inonotus nidus-pici is a sterile conk which produces macrofungus, a neglected Central-Eastern European relative of the prized Inonotus obliquus, also known as chaga. Investigation of the methanol extract of the poroid fungus I. nidus-pici resulted in the isolation of citropremide (1), 3,4-dihydroxybenzalacetone (2) , lanosterol (3), ergost-6,8,22-trien-3β-ol (4), and ergosterol peroxide (5). The structures of fungal compounds were determined on the basis of one- and two-dimensional NMR and MS spectroscopic analysis. Compounds 1–2 and 4–5 were evaluated for their antioxidant and antimicrobial properties against several bacterial and fungal strains. 3,4-dihydroxybenzalacetone (2) and ergost-6,8,22-trien-3β-ol (4) demonstrated moderate antimicrobial activity, while the former possessed notable antioxidant activity in DPPH assay. The antiproliferative examinations performed on three human cancer (MES-SA, MES-SA/Dx5, A431) cell lines demonstrated that compounds 4 and 5 have notable cytotoxic activity with IC values in micromolar range. The current study represents the first report on the chemical profile of I. nidus-pici, providing a comprehensive study on the isolation and structure determination of bioactive secondary metabolites of this macrofungus. |
format | Online Article Text |
id | pubmed-8468361 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84683612021-09-27 Antimicrobial, Antioxidant and Antiproliferative Secondary Metabolites from Inonotus nidus-pici Garádi, Zsófia Dékány, Miklós Móricz, Ágnes M. Gaál, Anikó Papp, Viktor Béni, Szabolcs Ványolós, Attila Molecules Article Inonotus nidus-pici is a sterile conk which produces macrofungus, a neglected Central-Eastern European relative of the prized Inonotus obliquus, also known as chaga. Investigation of the methanol extract of the poroid fungus I. nidus-pici resulted in the isolation of citropremide (1), 3,4-dihydroxybenzalacetone (2) , lanosterol (3), ergost-6,8,22-trien-3β-ol (4), and ergosterol peroxide (5). The structures of fungal compounds were determined on the basis of one- and two-dimensional NMR and MS spectroscopic analysis. Compounds 1–2 and 4–5 were evaluated for their antioxidant and antimicrobial properties against several bacterial and fungal strains. 3,4-dihydroxybenzalacetone (2) and ergost-6,8,22-trien-3β-ol (4) demonstrated moderate antimicrobial activity, while the former possessed notable antioxidant activity in DPPH assay. The antiproliferative examinations performed on three human cancer (MES-SA, MES-SA/Dx5, A431) cell lines demonstrated that compounds 4 and 5 have notable cytotoxic activity with IC values in micromolar range. The current study represents the first report on the chemical profile of I. nidus-pici, providing a comprehensive study on the isolation and structure determination of bioactive secondary metabolites of this macrofungus. MDPI 2021-09-07 /pmc/articles/PMC8468361/ /pubmed/34576923 http://dx.doi.org/10.3390/molecules26185453 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Garádi, Zsófia Dékány, Miklós Móricz, Ágnes M. Gaál, Anikó Papp, Viktor Béni, Szabolcs Ványolós, Attila Antimicrobial, Antioxidant and Antiproliferative Secondary Metabolites from Inonotus nidus-pici |
title | Antimicrobial, Antioxidant and Antiproliferative Secondary Metabolites from Inonotus nidus-pici |
title_full | Antimicrobial, Antioxidant and Antiproliferative Secondary Metabolites from Inonotus nidus-pici |
title_fullStr | Antimicrobial, Antioxidant and Antiproliferative Secondary Metabolites from Inonotus nidus-pici |
title_full_unstemmed | Antimicrobial, Antioxidant and Antiproliferative Secondary Metabolites from Inonotus nidus-pici |
title_short | Antimicrobial, Antioxidant and Antiproliferative Secondary Metabolites from Inonotus nidus-pici |
title_sort | antimicrobial, antioxidant and antiproliferative secondary metabolites from inonotus nidus-pici |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468361/ https://www.ncbi.nlm.nih.gov/pubmed/34576923 http://dx.doi.org/10.3390/molecules26185453 |
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