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P-101 IMPACT OF COMPLETE AND PREVENTIVE LOCKED–DOWN BEFORE COVID 19 OUTBREAK IN ORGAN PROCUREMENT AND SOLID TRANSPLANTATION IN ARGENTINA: THE WORST HAS NOT YET ARRIVED.
INTRODUCTION: Early preventive strict quarantine due to COVID-19 pandemic was implemented in Argentina since March 20th, 2020. Transplant societies and organ procurement organizations were challenged to face this complex scenario and sustain organ donation and transplantation activity. OBJECTIVES: W...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Published by Elsevier España, S.L.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468369/ http://dx.doi.org/10.1016/j.aohep.2021.100461 |
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author | Pages, Josefina Piñero, Federico Anders, Margarita Thompson, Marcos Gonzalez Campaña, Ariel Mendizabal, Manuel Fauda, Martín Antinucci, Florencia Orozco Ganem, Federico Grigera, Nadia McCormack, Lucas Podesta, Gustavo Silva, Marcelo |
author_facet | Pages, Josefina Piñero, Federico Anders, Margarita Thompson, Marcos Gonzalez Campaña, Ariel Mendizabal, Manuel Fauda, Martín Antinucci, Florencia Orozco Ganem, Federico Grigera, Nadia McCormack, Lucas Podesta, Gustavo Silva, Marcelo |
author_sort | Pages, Josefina |
collection | PubMed |
description | INTRODUCTION: Early preventive strict quarantine due to COVID-19 pandemic was implemented in Argentina since March 20th, 2020. Transplant societies and organ procurement organizations were challenged to face this complex scenario and sustain organ donation and transplantation activity. OBJECTIVES: We evaluated the impact of complete and preventive lockdown in organ procurement and transplantation before the COVID-19 peak onset. MATERIALS AND METHODS: We analyzed prospectively collected data from the National Report Agency (INCUCAI). By constructing time series, we compared donation and transplant rates from the years 2010 to 2020, during a same monthly-period between March 3rd and July 20th. We evaluated the effect of preventive lockdown before the peak of COVID-19 curve. Donation rates per million population in these months were also registered for each year. Transplant accessibility was calculated, dividing the total number of transplants and the total number of listed patients. RESULTS: The preventive lockdown was associated with a 34.5% relative reduction (95% CI 26.9-43.2) in organ procurement when compared to 2010-2019 and significantly reduced comparing 2019 [53.3% (CI 44.6-61.6)]. This scenario was even worse in Buenos Aires city and its surroundings, the region most affected by COVID-19. During this period, donation per million population rates decreased from 7.8 in 2019 to 3.3 in 2020. This reduction was even higher in the number of deceased and living donor transplants performed comparing 2019 vs. 2020, with a relative reduction of 62.0% (CI 30.8-89.1) and 68.8% (CI 65.7-71.7), respectively. CONCLUSIONS: During this short observation period of 120 days of preventive quarantine, not yet having reached the "peak" incidence of COVID-19, a marked reduction in procurement and transplantation rates were observed. Although waiting list mortality was not significantly modified, transplant access has been significantly reduced, showing a future negative trend on waitlist mortality. |
format | Online Article Text |
id | pubmed-8468369 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Published by Elsevier España, S.L. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84683692021-09-27 P-101 IMPACT OF COMPLETE AND PREVENTIVE LOCKED–DOWN BEFORE COVID 19 OUTBREAK IN ORGAN PROCUREMENT AND SOLID TRANSPLANTATION IN ARGENTINA: THE WORST HAS NOT YET ARRIVED. Pages, Josefina Piñero, Federico Anders, Margarita Thompson, Marcos Gonzalez Campaña, Ariel Mendizabal, Manuel Fauda, Martín Antinucci, Florencia Orozco Ganem, Federico Grigera, Nadia McCormack, Lucas Podesta, Gustavo Silva, Marcelo Ann Hepatol Article INTRODUCTION: Early preventive strict quarantine due to COVID-19 pandemic was implemented in Argentina since March 20th, 2020. Transplant societies and organ procurement organizations were challenged to face this complex scenario and sustain organ donation and transplantation activity. OBJECTIVES: We evaluated the impact of complete and preventive lockdown in organ procurement and transplantation before the COVID-19 peak onset. MATERIALS AND METHODS: We analyzed prospectively collected data from the National Report Agency (INCUCAI). By constructing time series, we compared donation and transplant rates from the years 2010 to 2020, during a same monthly-period between March 3rd and July 20th. We evaluated the effect of preventive lockdown before the peak of COVID-19 curve. Donation rates per million population in these months were also registered for each year. Transplant accessibility was calculated, dividing the total number of transplants and the total number of listed patients. RESULTS: The preventive lockdown was associated with a 34.5% relative reduction (95% CI 26.9-43.2) in organ procurement when compared to 2010-2019 and significantly reduced comparing 2019 [53.3% (CI 44.6-61.6)]. This scenario was even worse in Buenos Aires city and its surroundings, the region most affected by COVID-19. During this period, donation per million population rates decreased from 7.8 in 2019 to 3.3 in 2020. This reduction was even higher in the number of deceased and living donor transplants performed comparing 2019 vs. 2020, with a relative reduction of 62.0% (CI 30.8-89.1) and 68.8% (CI 65.7-71.7), respectively. CONCLUSIONS: During this short observation period of 120 days of preventive quarantine, not yet having reached the "peak" incidence of COVID-19, a marked reduction in procurement and transplantation rates were observed. Although waiting list mortality was not significantly modified, transplant access has been significantly reduced, showing a future negative trend on waitlist mortality. Published by Elsevier España, S.L. 2021-09 2021-09-26 /pmc/articles/PMC8468369/ http://dx.doi.org/10.1016/j.aohep.2021.100461 Text en Copyright © 2021 Published by Elsevier España, S.L. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Pages, Josefina Piñero, Federico Anders, Margarita Thompson, Marcos Gonzalez Campaña, Ariel Mendizabal, Manuel Fauda, Martín Antinucci, Florencia Orozco Ganem, Federico Grigera, Nadia McCormack, Lucas Podesta, Gustavo Silva, Marcelo P-101 IMPACT OF COMPLETE AND PREVENTIVE LOCKED–DOWN BEFORE COVID 19 OUTBREAK IN ORGAN PROCUREMENT AND SOLID TRANSPLANTATION IN ARGENTINA: THE WORST HAS NOT YET ARRIVED. |
title | P-101 IMPACT OF COMPLETE AND PREVENTIVE LOCKED–DOWN BEFORE COVID 19 OUTBREAK IN ORGAN PROCUREMENT AND SOLID TRANSPLANTATION IN ARGENTINA: THE WORST HAS NOT YET ARRIVED. |
title_full | P-101 IMPACT OF COMPLETE AND PREVENTIVE LOCKED–DOWN BEFORE COVID 19 OUTBREAK IN ORGAN PROCUREMENT AND SOLID TRANSPLANTATION IN ARGENTINA: THE WORST HAS NOT YET ARRIVED. |
title_fullStr | P-101 IMPACT OF COMPLETE AND PREVENTIVE LOCKED–DOWN BEFORE COVID 19 OUTBREAK IN ORGAN PROCUREMENT AND SOLID TRANSPLANTATION IN ARGENTINA: THE WORST HAS NOT YET ARRIVED. |
title_full_unstemmed | P-101 IMPACT OF COMPLETE AND PREVENTIVE LOCKED–DOWN BEFORE COVID 19 OUTBREAK IN ORGAN PROCUREMENT AND SOLID TRANSPLANTATION IN ARGENTINA: THE WORST HAS NOT YET ARRIVED. |
title_short | P-101 IMPACT OF COMPLETE AND PREVENTIVE LOCKED–DOWN BEFORE COVID 19 OUTBREAK IN ORGAN PROCUREMENT AND SOLID TRANSPLANTATION IN ARGENTINA: THE WORST HAS NOT YET ARRIVED. |
title_sort | p-101 impact of complete and preventive locked–down before covid 19 outbreak in organ procurement and solid transplantation in argentina: the worst has not yet arrived. |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468369/ http://dx.doi.org/10.1016/j.aohep.2021.100461 |
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